Engineered immune cells take on Hard-to-Treat prostate cancer
NCT ID NCT06236139
First seen Jun 27, 2026 · Last updated Aug 12, 2026 · Updated 2 times
Summary
This study tests whether a new cell therapy called STEAP1 CAR T, given together with the hormone drug enzalutamide, is safe and effective for men with metastatic castration-resistant prostate cancer (mCRPC). The therapy uses a patient's own immune cells, modified in the lab to better target prostate cancer cells. The trial will enroll 48 participants and monitor side effects, tumor shrinkage, and PSA levels.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- STEAP1 CAR T-cells (a type of cell therapy) and enzalutamide (a hormone-blocking drug)
- What this could lead to
- If successful, this combination could offer a new treatment option for men with advanced prostate cancer that has stopped responding to standard therapies.
- What could go wrong
- This is an early-phase trial with only 48 participants, so results may not apply broadly. CAR T-cell therapy can cause serious side effects, and it is unknown if the combination will work better than existing treatments.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
Fred Hutch/University of Washington Cancer Consortium
RECRUITINGSeattle, Washington, 98109, United States
More trials for these conditions
Other studies related to the condition(s) this trial covers.
- Can a new drug tame metastatic prostate cancer? a phase 1 trial aims to find out
- Mapping radiation dose in real time: a smarter way to treat prostate cancer?
- Can a tracer that hunts unstable iron light up hidden tumors?
- Can a three-drug cocktail outsmart resistant prostate cancer?
- Precision radiation may tame rising PSA after prostate surgery
- New prostate cancer drug HRS-7525 enters first human tests