Gene-Guided therapy could revolutionize prostate cancer care

NCT ID NCT06632977

Recruiting now Disease control Sponsor: Alliance for Clinical Trials in Oncology Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Aug 06, 2026 · Updated 3 times

Summary

This study tests whether analyzing a patient's tumor DNA and RNA can help doctors select the most effective treatment for advanced prostate cancer that no longer responds to hormone therapy. About 474 participants will receive one of several drugs based on their genetic profile. The goal is to see if this personalized approach shrinks tumors or slows disease progression better than standard care.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: valemetostat tosylate, carboplatin, cabazitaxel, abiraterone acetate, enzalutamide, lutetium Lu 177 vipivotide tetraxetan
What this could lead to: If successful, this trial could show that genetic testing helps doctors pick the most effective drug for each patient, potentially slowing cancer growth and improving survival.
What could go wrong: This is a phase II trial with 474 participants, so results are still early. The genetic testing may not always lead to a better outcome, and some drugs have side effects like fatigue, low blood counts, or organ damage.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

castration-resistant prostate carcinoma metastatic prostate carcinoma prostate cancer

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

CASTRATION-RESISTANT PROSTATE CARCINOMA STAGE IVB PROSTATE CANCER AJCC V8

Contacts and locations

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Locations

Banner University Medical Center - Tucson
RECRUITING

Tucson, Arizona, 85719, United States
Baystate Medical Center
RECRUITING

Springfield, Massachusetts, 01199, United States
Beebe Health Campus
RECRUITING

Rehoboth Beach, Delaware, 19971, United States

Contact Email: •••••@•••••
Beebe South Coastal Health Campus
RECRUITING

Millville, Delaware, 19967, United States

Contact Email: •••••@•••••
Billings Clinic Cancer Center
RECRUITING

Billings, Montana, 59101, United States

Contact Email: •••••@•••••
Bon Secours Cancer Institute at Reynolds Crossing
RECRUITING

Richmond, Virginia, 23230, United States
Bon Secours Memorial Regional Medical Center
RECRUITING

Mechanicsville, Virginia, 23116, United States
Bon Secours Richmond Community Hospital
RECRUITING

Richmond, Virginia, 23223, United States
Bon Secours Saint Francis Medical Center
RECRUITING

Midlothian, Virginia, 23114, United States
Bon Secours Saint Mary's Hospital
RECRUITING

Richmond, Virginia, 23226, United States
Cancer Care Center of O'Fallon
RECRUITING

O'Fallon, Illinois, 62269, United States
Cancer Care and Hematology-Fort Collins
RECRUITING

Fort Collins, Colorado, 80528, United States
Carle Cancer Center
RECRUITING

Urbana, Illinois, 61801, United States

Contact Email: •••••@•••••
Carle Physician Group-Effingham
RECRUITING

Effingham, Illinois, 62401, United States

Contact Email: •••••@•••••
Carle Physician Group-Mattoon/Charleston
RECRUITING

Mattoon, Illinois, 61938, United States

Contact Email: •••••@•••••
Carle at The Riverfront
RECRUITING

Danville, Illinois, 61832, United States

Contact Email: •••••@•••••
Coborn Cancer Center at Saint Cloud Hospital
RECRUITING

Saint Cloud, Minnesota, 56303, United States

Contact Email: •••••@•••••
Dana Farber-Merrimack Valley
RECRUITING

Methuen, Massachusetts, 01844, United States
Dana-Farber Cancer Institute
SUSPENDED

Boston, Massachusetts, 02215, United States
Dana-Farber Cancer Institute at Foxborough
RECRUITING

Foxborough, Massachusetts, 02035, United States
Dana-Farber/Brigham and Women's Cancer Center at Milford Regional
RECRUITING

Milford, Massachusetts, 01757, United States
Dana-Farber/Brigham and Women's Cancer Center at South Shore
RECRUITING

South Weymouth, Massachusetts, 02190, United States
Drexel Town Square Health Center
RECRUITING

Oak Creek, Wisconsin, 53154, United States
Edwards Comprehensive Cancer Center
RECRUITING

Huntington, West Virginia, 25701, United States
Enloe Medical Center
RECRUITING

Chico, California, 95926, United States
Essentia Health Cancer Center
RECRUITING

Duluth, Minnesota, 55805, United States

Contact Email: •••••@•••••
Essentia Health Cancer Center-South University Clinic
RECRUITING

Fargo, North Dakota, 58103, United States

Contact Email: •••••@•••••
Essentia Health Saint Joseph's Medical Center
RECRUITING

Brainerd, Minnesota, 56401, United States

Contact Email: •••••@•••••
Froedtert Menomonee Falls Hospital
RECRUITING

Menomonee Falls, Wisconsin, 53051, United States
Froedtert West Bend Hospital/Kraemer Cancer Center
RECRUITING

West Bend, Wisconsin, 53095, United States
Gibbs Cancer Center-Gaffney
RECRUITING

Gaffney, South Carolina, 29341, United States
Gibbs Cancer Center-Pelham
RECRUITING

Greer, South Carolina, 29651, United States
Guthrie Medical Group PC-Robert Packer Hospital
ACTIVE_NOT_RECRUITING

Sayre, Pennsylvania, 18840, United States
Hackensack University Medical Center
RECRUITING

Hackensack, New Jersey, 07601, United States
Helen F Graham Cancer Center
RECRUITING

Newark, Delaware, 19713, United States
Illinois CancerCare - Washington
RECRUITING

Washington, Illinois, 61571, United States
Illinois CancerCare-Bloomington
RECRUITING

Bloomington, Illinois, 61704, United States
Illinois CancerCare-Canton
RECRUITING

Canton, Illinois, 61520, United States
Illinois CancerCare-Eureka
RECRUITING

Eureka, Illinois, 61530, United States
Illinois CancerCare-Ottawa Clinic
RECRUITING

Ottawa, Illinois, 61350, United States
Illinois CancerCare-Pekin
RECRUITING

Pekin, Illinois, 61554, United States
Illinois CancerCare-Peoria
RECRUITING

Peoria, Illinois, 61615, United States
Illinois CancerCare-Peru
RECRUITING

Peru, Illinois, 61354, United States
Jupiter Medical Center
RECRUITING

Jupiter, Florida, 33458, United States

Contact Email: •••••@•••••
Kootenai Health - Coeur d'Alene
SUSPENDED

Coeur d'Alene, Idaho, 83814, United States
MU Health - University Hospital/Ellis Fischel Cancer Center
ACTIVE_NOT_RECRUITING

Columbia, Missouri, 65212, United States
Marshfield Medical Center-Marshfield
SUSPENDED

Marshfield, Wisconsin, 54449, United States
McFarland Clinic - Ames
RECRUITING

Ames, Iowa, 50010, United States
Medical Center of the Rockies
RECRUITING

Loveland, Colorado, 80538, United States
Medical College of Wisconsin
RECRUITING

Milwaukee, Wisconsin, 53226, United States
Medical Oncology Hematology Consultants PA
RECRUITING

Newark, Delaware, 19713, United States
Memorial Hospital East
RECRUITING

Shiloh, Illinois, 62269, United States
Memorial Hospital North
RECRUITING

Colorado Springs, Colorado, 80920, United States
MetroHealth Medical Center
RECRUITING

Cleveland, Ohio, 44109, United States
Mount Sinai Hospital
RECRUITING

New York, New York, 10029, United States
Ohio State University Comprehensive Cancer Center
RECRUITING

Columbus, Ohio, 43210, United States
Oregon Health and Science University
RECRUITING

Portland, Oregon, 97239, United States

Contact Email: •••••@•••••
Parkland Memorial Hospital
RECRUITING

Dallas, Texas, 75235, United States

Contact Email: •••••@•••••
Poudre Valley Hospital
RECRUITING

Fort Collins, Colorado, 80524, United States
Providence Portland Medical Center
RECRUITING

Portland, Oregon, 97213, United States

Contact Email: •••••@•••••
Providence Saint Vincent Medical Center
RECRUITING

Portland, Oregon, 97225, United States

Contact Email: •••••@•••••
Roswell Park Cancer Institute
RECRUITING

Buffalo, New York, 14263, United States
SMC Center for Hematology Oncology Union
RECRUITING

Union, South Carolina, 29379, United States
Saint Elizabeth Healthcare Edgewood
RECRUITING

Edgewood, Kentucky, 41017, United States
Saint Elizabeth Healthcare Fort Thomas
SUSPENDED

Fort Thomas, Kentucky, 41075, United States
Siteman Cancer Center at Christian Hospital
RECRUITING

St Louis, Missouri, 63136, United States

Contact Email: •••••@•••••
Siteman Cancer Center at Saint Peters Hospital
RECRUITING

City of Saint Peters, Missouri, 63376, United States

Contact Email: •••••@•••••
Siteman Cancer Center at West County Hospital
RECRUITING

Creve Coeur, Missouri, 63141, United States

Contact Email: •••••@•••••
Siteman Cancer Center-South County
RECRUITING

St Louis, Missouri, 63129, United States

Contact Email: •••••@•••••
Spartanburg Medical Center
RECRUITING

Spartanburg, South Carolina, 29303, United States
Stamford Hospital/Bennett Cancer Center
RECRUITING

Stamford, Connecticut, 06904, United States
Swedish Cancer Institute-Edmonds
RECRUITING

Edmonds, Washington, 98026, United States
Swedish Medical Center-First Hill
RECRUITING

Seattle, Washington, 98122, United States
The University of Kansas Cancer Center - Olathe
RECRUITING

Olathe, Kansas, 66061, United States

Contact Email: •••••@•••••
Trinity Health IHA Medical Group Hematology Oncology - Brighton
RECRUITING

Brighton, Michigan, 48114, United States
Trinity Health IHA Medical Group Hematology Oncology - Canton
RECRUITING

Canton, Michigan, 48188, United States
Trinity Health IHA Medical Group Hematology Oncology - Chelsea Hospital
RECRUITING

Chelsea, Michigan, 48118, United States
Trinity Health IHA Medical Group Hematology Oncology Ann Arbor Campus
RECRUITING

Ypsilanti, Michigan, 48197, United States
Trinity Health Saint Mary Mercy Livonia Hospital
RECRUITING

Livonia, Michigan, 48154, United States
Tripler Army Medical Center
RECRUITING

Honolulu, Hawaii, 96859, United States
UC Irvine Health/Chao Family Comprehensive Cancer Center
RECRUITING

Orange, California, 92868, United States

Contact Email: •••••@•••••
UC San Diego Health System - Encinitas
RECRUITING

Encinitas, California, 92024, United States
UC San Diego Medical Center - Hillcrest
RECRUITING

San Diego, California, 92103, United States
UC San Diego Moores Cancer Center
RECRUITING

La Jolla, California, 92093, United States

Contact Email: •••••@•••••
UCHealth Greeley Hospital
RECRUITING

Greeley, Colorado, 80631, United States
UCHealth Memorial Hospital Central
RECRUITING

Colorado Springs, Colorado, 80909, United States
UCI Health - Chao Family Comprehensive Cancer Center and Ambulatory Care
RECRUITING

Irvine, California, 92612, United States

Contact Email: •••••@•••••
UNC Lineberger Comprehensive Cancer Center
RECRUITING

Chapel Hill, North Carolina, 27599, United States

Contact Email: •••••@•••••
UT Southwestern Clinical Center at Richardson/Plano
RECRUITING

Richardson, Texas, 75080, United States
UT Southwestern Simmons Cancer Center - RedBird
RECRUITING

Dallas, Texas, 75237, United States

Contact Email: •••••@•••••
UT Southwestern/Simmons Cancer Center-Dallas
RECRUITING

Dallas, Texas, 75390, United States

Contact Email: •••••@•••••
UT Southwestern/Simmons Cancer Center-Fort Worth
RECRUITING

Fort Worth, Texas, 76104, United States

Contact Email: •••••@•••••
University of Alabama at Birmingham Cancer Center
RECRUITING

Birmingham, Alabama, 35233, United States
University of Arizona Cancer Center-North Campus
RECRUITING

Tucson, Arizona, 85719, United States
University of California Davis Comprehensive Cancer Center
RECRUITING

Sacramento, California, 95817, United States
University of Iowa Healthcare Cancer Services Quad Cities
RECRUITING

Bettendorf, Iowa, 52722, United States
University of Iowa/Holden Comprehensive Cancer Center
RECRUITING

Iowa City, Iowa, 52242, United States
University of Kansas Cancer Center
RECRUITING

Kansas City, Kansas, 66160, United States
University of Kansas Health System Saint Francis Campus
RECRUITING

Topeka, Kansas, 66606, United States
University of Kansas Hospital-Indian Creek Campus
RECRUITING

Overland Park, Kansas, 66211, United States
University of Kansas Hospital-Westwood Cancer Center
RECRUITING

Westwood, Kansas, 66205, United States
University of Michigan Health - Sparrow Lansing
RECRUITING

Lansing, Michigan, 48912, United States
University of Oklahoma Health Sciences Center
RECRUITING

Oklahoma City, Oklahoma, 73104, United States
VCU Massey Cancer Center at Stony Point
RECRUITING

Richmond, Virginia, 23235, United States
VCU Massey Comprehensive Cancer Center
RECRUITING

Richmond, Virginia, 23298, United States
Vanderbilt University/Ingram Cancer Center
SUSPENDED

Nashville, Tennessee, 37232, United States
Washington University School of Medicine
RECRUITING

St Louis, Missouri, 63110, United States

Contact Email: •••••@•••••
West Virginia University Charleston Division
ACTIVE_NOT_RECRUITING

Charleston, West Virginia, 25304, United States

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