Alliance For Clinical Trials In Oncology

This study is testing whether a new, step-by-step dosing guide called the PAGODA algorithm can help prevent unplanned delays in FOLFOX chemotherapy for people with gastrointestinal cancers. About 420 participants will be randomly assigned to have their chemotherapy doses adjusted…

This study is testing whether adding a new drug called iberdomide to an existing treatment (belantamab mafodotin and dexamethasone) is safe and more effective for people with multiple myeloma that has returned or stopped responding to other therapies. The trial will first find th…

This large, late-stage trial is testing which of two chemotherapy combinations works better for people with advanced stomach or esophageal cancer that has spread and cannot be removed by surgery. About 382 participants will be randomly assigned to receive either the standard two-…

This large, late-stage trial is testing if adding a chemotherapy drug called gemcitabine to the standard BCG treatment is more effective at controlling recurrent, high-grade bladder cancer that hasn't invaded the muscle wall. The study will compare the combination treatment again…

This large study is testing if adding a chemotherapy drug (docetaxel) to the current standard two-drug hormone therapy helps men with prostate cancer that has spread live longer. It will enroll about 1,260 men to compare the three-drug combination against the standard two-drug tr…

This study is testing if giving two immunotherapy drugs before surgery helps control a rare and aggressive type of lung cancer called sarcomatoid mesothelioma. The goal is to see if this approach helps more patients get to surgery and keeps the cancer from growing back longer. Re…

This study is testing whether older patients with a type of blood cancer called mantle cell lymphoma can safely take breaks from their maintenance medication. Currently, patients take the drug zanubrutinib continuously, which can cause side effects and be costly. This trial will …

This large study is for people with early-stage triple-negative breast cancer who had no detectable cancer left after their initial chemo-immunotherapy and surgery. It aims to find out if simply watching closely (observation) works just as well at preventing the cancer from comin…

This study is for people with colorectal cancer that has spread to up to four other places in the body. It compares the usual approach of chemotherapy drugs alone to a more aggressive strategy that adds targeted treatments to eliminate the visible cancer spots. These added treatm…

This study is testing if a text message program is better than a quit-smoking booklet at helping rural cancer survivors stop smoking. It will enroll 600 adults who smoke and have had a cancer diagnosis in the last 10 years. The main goal is to see if the text-based support leads …

This large, phase 3 trial is testing if a shorter, 6-month course of targeted antibody therapy works as well as the standard 12-month course for patients with early-stage HER2-positive breast cancer. It is for patients who had no detectable cancer left after their initial chemoth…

This study is testing a standard chemotherapy combination (gemcitabine and cisplatin) for people with invasive bladder cancer. The main goal is to see if patients whose tumors have specific genetic changes related to DNA repair can successfully control their cancer and keep their…

This large, late-stage trial is testing if a two-drug combination works better than the current standard single drug to prevent kidney cancer from returning after surgery. It will enroll over 1,000 patients whose cancer is at high risk of coming back. The goal is to see if adding…

This large study aims to find the best timing for cancer treatments in people with operable non-small cell lung cancer. It will compare the standard approach of giving chemotherapy and immunotherapy only after surgery to a newer approach of giving it both before and after surgery…

This study is testing four different targeted drugs for adults with meningioma brain tumors that are growing or have come back after treatment. The specific drug a patient receives is chosen based on the unique genetic mutations found in their tumor. The main goal is to see if th…

This study is testing whether using genetic testing to guide treatment choices works better for men with advanced prostate cancer that has stopped responding to standard hormone therapy. About 474 participants will have their tumor tissue analyzed, and then be assigned to one of …

This study aims to collect blood and tissue samples to help develop a single blood test that can detect many different cancers early. Researchers will enroll 2,000 people, including those with cancer and those without, to create a reference set for testing. The goal is to validat…

This study is testing if a virtual exercise program can be successfully delivered to people receiving chemotherapy for cancer. The goal is to see if exercising at home can help patients manage common treatment side effects like fatigue and loss of strength. The program includes s…

This study compares two medications—olanzapine and megestrol acetate—to see which works better at improving appetite and preventing weight loss in people with advanced cancer. Researchers will enroll 360 patients who have lost weight and have poor appetite due to their cancer. Pa…

This large, late-stage trial is testing if a high dose of the drug gabapentin, started early, can prevent the need for strong opioid painkillers in patients receiving chemotherapy and radiation for head and neck cancer. The goal is to manage the severe mouth sores and pain that a…

This study is creating a national collection of blood and tissue samples from cancer patients who experience serious side effects from immunotherapy drugs. Researchers will collect samples and review medical records to build a resource for future studies. The goal is to help scie…

This study is testing whether a digital chatbot can help more young adult cancer patients get recommended genetic counseling and testing, compared to standard telehealth visits. It aims to see if the chatbot is just as good at helping patients understand their genetic risks and f…