New combo aims to beat standard CLL therapy in older patients

NCT ID NCT07321652

Recruiting now Disease control Sponsor: Alliance for Clinical Trials in Oncology Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Aug 06, 2026 · Updated 3 times

Summary

This Phase 3 trial compares a fixed-duration combination of zanubrutinib and sonrotoclax against continuous zanubrutinib alone in older patients with untreated chronic lymphocytic leukemia or small lymphocytic lymphoma. The study will enroll 466 participants to see if the combo improves progression-free survival. Sonrotoclax blocks a protein that helps cancer cells survive, while zanubrutinib targets another protein that fuels cancer growth.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: zanubrutinib and sonrotoclax
What this could lead to: If successful, this could offer a more effective, time-limited treatment option for older patients with CLL/SLL, potentially improving progression-free survival without lifelong therapy.
What could go wrong: This is an early Phase 3 trial, so results are not yet known. Adding sonrotoclax may increase side effects, and the fixed-duration approach might not be as effective as continuous therapy for all patients.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

B-cell chronic lymphocytic leukemia chronic lymphocytic leukemia/small lymphocytic lymphoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

CHRONIC LYMPHOCYTIC LEUKEMIA SMALL LYMPHOCYTIC LEUKEMIA

Contacts and locations

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Locations

Abbott-Northwestern Hospital
RECRUITING

Minneapolis, Minnesota, 55407, United States
Ascension Via Christi Hospitals Wichita
RECRUITING

Wichita, Kansas, 67214, United States

Contact Email: •••••@•••••
Avera Cancer Institute
RECRUITING

Sioux Falls, South Dakota, 57105, United States

Contact Email: •••••@•••••
Avera Cancer Institute - Mitchell
RECRUITING

Mitchell, South Dakota, 57301, United States

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Avera Cancer Institute at Pierre
RECRUITING

Pierre, South Dakota, 57501, United States

Contact Email: •••••@•••••
Avera Cancer Institute at Yankton
RECRUITING

Yankton, South Dakota, 57078, United States

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Avera Cancer Institute-Aberdeen
RECRUITING

Aberdeen, South Dakota, 57401, United States

Contact Email: •••••@•••••
Baptist Memorial Hospital and Cancer Center-Collierville
RECRUITING

Collierville, Tennessee, 38017, United States

Contact Email: •••••@•••••
Baptist Memorial Hospital and Cancer Center-Desoto
RECRUITING

Southhaven, Mississippi, 38671, United States

Contact Email: •••••@•••••
Baptist Memorial Hospital and Cancer Center-Memphis
RECRUITING

Memphis, Tennessee, 38120, United States

Contact Email: •••••@•••••
Benefis Sletten Cancer Institute
RECRUITING

Great Falls, Montana, 59405, United States

Contact Email: •••••@•••••
Billings Clinic Cancer Center
RECRUITING

Billings, Montana, 59101, United States

Contact Email: •••••@•••••
Bozeman Health Deaconess Hospital
RECRUITING

Bozeman, Montana, 59715, United States

Contact Email: •••••@•••••
Broadlawns Medical Center
RECRUITING

Des Moines, Iowa, 50314, United States
Cancer Care Center of O'Fallon
RECRUITING

O'Fallon, Illinois, 62269, United States
Cancer Care Specialists of Illinois - Decatur
RECRUITING

Decatur, Illinois, 62526, United States
Cancer Center of Kansas - Chanute
RECRUITING

Chanute, Kansas, 66720, United States

Contact Email: •••••@•••••
Cancer Center of Kansas - Dodge City
RECRUITING

Dodge City, Kansas, 67801, United States

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Cancer Center of Kansas - El Dorado
RECRUITING

El Dorado, Kansas, 67042, United States

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Cancer Center of Kansas - McPherson
RECRUITING

McPherson, Kansas, 67460, United States

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Cancer Center of Kansas - Newton
RECRUITING

Newton, Kansas, 67114, United States

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Cancer Center of Kansas - Parsons
RECRUITING

Parsons, Kansas, 67357, United States

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Cancer Center of Kansas - Pratt
RECRUITING

Pratt, Kansas, 67124, United States

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Cancer Center of Kansas - Salina
RECRUITING

Salina, Kansas, 67401, United States

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Cancer Center of Kansas - Wellington
RECRUITING

Wellington, Kansas, 67152, United States

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Cancer Center of Kansas - Wichita
RECRUITING

Wichita, Kansas, 67214, United States

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Cancer Center of Kansas - Winfield
RECRUITING

Winfield, Kansas, 67156, United States

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Cancer Center of Kansas-Independence
RECRUITING

Independence, Kansas, 67301, United States

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Cancer Center of Kansas-Kingman
RECRUITING

Kingman, Kansas, 67068, United States

Contact Email: •••••@•••••
Cancer Center of Kansas-Liberal
RECRUITING

Liberal, Kansas, 67905, United States

Contact Email: •••••@•••••
Cancer Center of Kansas-Wichita Medical Arts Tower
RECRUITING

Wichita, Kansas, 67208, United States

Contact Email: •••••@•••••
Carle BroMenn Medical Center
RECRUITING

Normal, Illinois, 61761, United States

Contact Email: •••••@•••••
Carle Cancer Center
RECRUITING

Urbana, Illinois, 61801, United States

Contact Email: •••••@•••••
Carle Cancer Institute Normal
RECRUITING

Normal, Illinois, 61761, United States

Contact Email: •••••@•••••
Carle Physician Group-Effingham
RECRUITING

Effingham, Illinois, 62401, United States

Contact Email: •••••@•••••
Carle Physician Group-Mattoon/Charleston
RECRUITING

Mattoon, Illinois, 61938, United States

Contact Email: •••••@•••••
Carle at The Riverfront
RECRUITING

Danville, Illinois, 61832, United States

Contact Email: •••••@•••••
Cedars-Sinai Medical Center
RECRUITING

Los Angeles, California, 90048, United States

Contact Email: •••••@•••••
Columbus Oncology and Hematology Associates
RECRUITING

Dublin, Ohio, 43016, United States
Columbus Oncology and Hematology Associates Inc
RECRUITING

Columbus, Ohio, 43214, United States
Community Hospital of Anaconda
RECRUITING

Anaconda, Montana, 59711, United States

Contact Email: •••••@•••••
Community Medical Center
RECRUITING

Missoula, Montana, 59804, United States

Contact Email: •••••@•••••
Dana-Farber Cancer Institute
RECRUITING

Boston, Massachusetts, 02215, United States
Decatur Memorial Hospital
RECRUITING

Decatur, Illinois, 62526, United States
Delaware Health Center-Grady Cancer Center
RECRUITING

Delaware, Ohio, 43015, United States
Doctors Hospital
RECRUITING

Columbus, Ohio, 43228, United States
Dublin Methodist Hospital
RECRUITING

Dublin, Ohio, 43016, United States
Duke University Medical Center
RECRUITING

Durham, North Carolina, 27710, United States
Duluth Clinic Ashland
RECRUITING

Ashland, Wisconsin, 54806, United States

Contact Email: •••••@•••••
Essentia Health - Deer River Clinic
RECRUITING

Deer River, Minnesota, 56636, United States

Contact Email: •••••@•••••
Essentia Health Cancer Center
RECRUITING

Duluth, Minnesota, 55805, United States

Contact Email: •••••@•••••
Essentia Health Cancer Center-South University Clinic
RECRUITING

Fargo, North Dakota, 58103, United States

Contact Email: •••••@•••••
Essentia Health Hibbing Clinic
RECRUITING

Hibbing, Minnesota, 55746, United States
Essentia Health Saint Joseph's Medical Center
RECRUITING

Brainerd, Minnesota, 56401, United States

Contact Email: •••••@•••••
Essentia Health Sandstone
RECRUITING

Sandstone, Minnesota, 55072, United States

Contact Email: •••••@•••••
Essentia Health Virginia Clinic
RECRUITING

Virginia, Minnesota, 55792, United States

Contact Email: •••••@•••••
Grady Memorial Hospital
RECRUITING

Delaware, Ohio, 43015, United States
Grant Medical Center
RECRUITING

Columbus, Ohio, 43215, United States
Gundersen Lutheran Medical Center
RECRUITING

La Crosse, Wisconsin, 54601, United States

Contact Email: •••••@•••••
HSHS Saint Elizabeth's Hospital
RECRUITING

O'Fallon, Illinois, 62269, United States
Idaho Urologic Institute-Meridian
RECRUITING

Meridian, Idaho, 83642, United States
Illinois CancerCare - Washington
RECRUITING

Washington, Illinois, 61571, United States
Illinois CancerCare-Bloomington
RECRUITING

Bloomington, Illinois, 61704, United States
Illinois CancerCare-Canton
RECRUITING

Canton, Illinois, 61520, United States
Illinois CancerCare-Carthage
RECRUITING

Carthage, Illinois, 62321, United States
Illinois CancerCare-Dixon
RECRUITING

Dixon, Illinois, 61021, United States
Illinois CancerCare-Eureka
RECRUITING

Eureka, Illinois, 61530, United States
Illinois CancerCare-Galesburg
RECRUITING

Galesburg, Illinois, 61401, United States
Illinois CancerCare-Kewanee Clinic
RECRUITING

Kewanee, Illinois, 61443, United States
Illinois CancerCare-Macomb
RECRUITING

Macomb, Illinois, 61455, United States
Illinois CancerCare-Ottawa Clinic
RECRUITING

Ottawa, Illinois, 61350, United States
Illinois CancerCare-Pekin
RECRUITING

Pekin, Illinois, 61554, United States
Illinois CancerCare-Peoria
RECRUITING

Peoria, Illinois, 61615, United States
Illinois CancerCare-Peru
RECRUITING

Peru, Illinois, 61354, United States
Illinois CancerCare-Princeton
RECRUITING

Princeton, Illinois, 61356, United States
Iowa Methodist Medical Center
RECRUITING

Des Moines, Iowa, 50309, United States
Jefferson Cherry Hill Hospital
RECRUITING

Cherry Hill, New Jersey, 08002, United States

Contact Email: •••••@•••••
Jefferson Torresdale Hospital
RECRUITING

Philadelphia, Pennsylvania, 19114, United States

Contact Email: •••••@•••••
Jupiter Medical Center
RECRUITING

Jupiter, Florida, 33458, United States

Contact Email: •••••@•••••
Kaiser Permanente - Panorama City
RECRUITING

Panorama City, California, 91402, United States

Contact Email: •••••@•••••
Kootenai Clinic Cancer Services - Post Falls
RECRUITING

Post Falls, Idaho, 83854, United States

Contact Email: •••••@•••••
Kootenai Clinic Cancer Services - Sandpoint
RECRUITING

Sandpoint, Idaho, 83864, United States

Contact Email: •••••@•••••
Kootenai Health - Coeur d'Alene
RECRUITING

Coeur d'Alene, Idaho, 83814, United States

Contact Email: •••••@•••••
Lawrence Memorial Hospital
RECRUITING

Lawrence, Kansas, 66044, United States
Logan Health Medical Center
RECRUITING

Kalispell, Montana, 59901, United States

Contact Email: •••••@•••••
MaineHealth Cancer Care and IV Therapy - South Portland
RECRUITING

South Portland, Maine, 04106, United States

Contact Email: •••••@•••••
MaineHealth Maine Medical Center - Portland
RECRUITING

Portland, Maine, 04102, United States

Contact Email: •••••@•••••
Margaret R Pardee Memorial Hospital
RECRUITING

Hendersonville, North Carolina, 28791, United States

Contact Email: •••••@•••••
Mary Greeley Medical Center
RECRUITING

Ames, Iowa, 50010, United States
McFarland Clinic - Ames
RECRUITING

Ames, Iowa, 50010, United States
McFarland Clinic - Marshalltown
RECRUITING

Marshalltown, Iowa, 50158, United States
McFarland Clinic - Trinity Cancer Center
RECRUITING

Fort Dodge, Iowa, 50501, United States
Memorial Hospital East
RECRUITING

Shiloh, Illinois, 62269, United States
Mercy Hospital
RECRUITING

Cedar Rapids, Iowa, 52403, United States
Mercy Hospital
RECRUITING

Coon Rapids, Minnesota, 55433, United States
Mercy Medical Center - Des Moines
RECRUITING

Des Moines, Iowa, 50314, United States
Missouri Baptist Medical Center
RECRUITING

St Louis, Missouri, 63131, United States
Missouri Baptist Sullivan Hospital
RECRUITING

Sullivan, Missouri, 63080, United States
Mount Sinai Medical Center
RECRUITING

Miami Beach, Florida, 33140, United States
Northwestern University
RECRUITING

Chicago, Illinois, 60611, United States

Contact Email: •••••@•••••
Ohio State University Comprehensive Cancer Center
RECRUITING

Columbus, Ohio, 43210, United States
OhioHealth Mansfield Hospital
RECRUITING

Mansfield, Ohio, 44903, United States
OhioHealth Marion General Hospital
RECRUITING

Marion, Ohio, 43302, United States
OhioHealth O'Bleness Hospital
RECRUITING

Athens, Ohio, 45701, United States
OhioHealth Pickerington Methodist Hospital
RECRUITING

Pickerington, Ohio, 43147, United States
OhioHealth Westerville Medical Campus/Westerville Cancer Center
RECRUITING

Westerville, Ohio, 43082, United States
Oncology Associates at Mercy Medical Center
RECRUITING

Cedar Rapids, Iowa, 52403, United States
Park Nicollet Clinic - Saint Louis Park
RECRUITING

Saint Louis Park, Minnesota, 55416, United States
Parkland Health Center - Farmington
RECRUITING

Farmington, Missouri, 63640, United States
ProHealth D N Greenwald Center
RECRUITING

Mukwonago, Wisconsin, 53149, United States
ProHealth Oconomowoc Memorial Hospital
RECRUITING

Oconomowoc, Wisconsin, 53066, United States
Providence Newberg Medical Center
RECRUITING

Newberg, Oregon, 97132, United States

Contact Email: •••••@•••••
Providence Portland Medical Center
RECRUITING

Portland, Oregon, 97213, United States

Contact Email: •••••@•••••
Providence Saint Vincent Medical Center
RECRUITING

Portland, Oregon, 97225, United States

Contact Email: •••••@•••••
Providence Willamette Falls Medical Center
RECRUITING

Oregon City, Oregon, 97045, United States

Contact Email: •••••@•••••
Regions Hospital
RECRUITING

Saint Paul, Minnesota, 55101, United States
Riverside Methodist Hospital
RECRUITING

Columbus, Ohio, 43214, United States
Saint Alphonsus Cancer Care Center-Baker City
RECRUITING

Baker City, Oregon, 97814, United States

Contact Email: •••••@•••••
Saint Alphonsus Cancer Care Center-Boise
RECRUITING

Boise, Idaho, 83706, United States
Saint Alphonsus Cancer Care Center-Caldwell
RECRUITING

Caldwell, Idaho, 83605, United States
Saint Alphonsus Cancer Care Center-Nampa
RECRUITING

Nampa, Idaho, 83687, United States

Contact Email: •••••@•••••
Saint Alphonsus Cancer Care Center-Ontario
RECRUITING

Ontario, Oregon, 97914, United States

Contact Email: •••••@•••••
Saint Anthony Regional Hospital
RECRUITING

Carroll, Iowa, 51401, United States
Saint Francis Medical Center
RECRUITING

Cape Girardeau, Missouri, 63703, United States
Saint Vincent Hospital Cancer Center Green Bay
RECRUITING

Green Bay, Wisconsin, 54301, United States
Saint Vincent Hospital Cancer Center at Oconto Falls
RECRUITING

Oconto Falls, Wisconsin, 54154, United States
Saint Vincent Hospital Cancer Center at Saint Mary's
RECRUITING

Green Bay, Wisconsin, 54303, United States
Saint Vincent Hospital Cancer Center at Sturgeon Bay
RECRUITING

Sturgeon Bay, Wisconsin, 54235-1495, United States
Sainte Genevieve County Memorial Hospital
RECRUITING

Sainte Genevieve, Missouri, 63670, United States
Salina Regional Health Center
RECRUITING

Salina, Kansas, 67401, United States
Sanford Bismarck Medical Center
RECRUITING

Bismarck, North Dakota, 58501, United States

Contact Email: •••••@•••••
Sanford Broadway Medical Center
RECRUITING

Fargo, North Dakota, 58122, United States

Contact Email: •••••@•••••
Sanford Cancer Center Oncology Clinic
RECRUITING

Sioux Falls, South Dakota, 57104, United States

Contact Email: •••••@•••••
Sanford Joe Lueken Cancer Center
RECRUITING

Bemidji, Minnesota, 56601, United States

Contact Email: •••••@•••••
Sanford Roger Maris Cancer Center
RECRUITING

Fargo, North Dakota, 58122, United States

Contact Email: •••••@•••••
Sanford USD Medical Center - Sioux Falls
RECRUITING

Sioux Falls, South Dakota, 57117-5134, United States

Contact Email: •••••@•••••
Sidney Kimmel Cancer Center Washington Township
RECRUITING

Sewell, New Jersey, 08080, United States

Contact Email: •••••@•••••
Siteman Cancer Center at Christian Hospital
RECRUITING

St Louis, Missouri, 63136, United States

Contact Email: •••••@•••••
Siteman Cancer Center at Saint Peters Hospital
RECRUITING

City of Saint Peters, Missouri, 63376, United States

Contact Email: •••••@•••••
Siteman Cancer Center at West County Hospital
RECRUITING

Creve Coeur, Missouri, 63141, United States

Contact Email: •••••@•••••
Siteman Cancer Center-South County
RECRUITING

St Louis, Missouri, 63129, United States

Contact Email: •••••@•••••
Southern Illinois University School of Medicine
RECRUITING

Springfield, Illinois, 62702, United States
Springfield Clinic
RECRUITING

Springfield, Illinois, 62702, United States
Springfield Memorial Hospital
RECRUITING

Springfield, Illinois, 62781, United States
Swedish Cancer Institute-Edmonds
RECRUITING

Edmonds, Washington, 98026, United States
Swedish Cancer Institute-Issaquah
SUSPENDED

Issaquah, Washington, 98029, United States
Swedish Medical Center-First Hill
RECRUITING

Seattle, Washington, 98122, United States
The James Graham Brown Cancer Center at University of Louisville
RECRUITING

Louisville, Kentucky, 40202, United States
The University of Kansas Cancer Center - Olathe
RECRUITING

Olathe, Kansas, 66061, United States

Contact Email: •••••@•••••
Thomas Jefferson University Hospital
RECRUITING

Philadelphia, Pennsylvania, 19107, United States

Contact Email: •••••@•••••
Trinity Health IHA Medical Group Hematology Oncology - Brighton
RECRUITING

Brighton, Michigan, 48114, United States
Trinity Health IHA Medical Group Hematology Oncology - Canton
RECRUITING

Canton, Michigan, 48188, United States
Trinity Health IHA Medical Group Hematology Oncology - Chelsea Hospital
RECRUITING

Chelsea, Michigan, 48118, United States
Trinity Health IHA Medical Group Hematology Oncology Ann Arbor Campus
RECRUITING

Ypsilanti, Michigan, 48197, United States
Trinity Health Saint Joseph Mercy Oakland Hospital
RECRUITING

Pontiac, Michigan, 48341, United States
Trinity Health Saint Mary Mercy Livonia Hospital
RECRUITING

Livonia, Michigan, 48154, United States
UI Health Care Mission Cancer and Blood - Ankeny Clinic
RECRUITING

Ankeny, Iowa, 50023, United States
UI Health Care Mission Cancer and Blood - Des Moines Clinic
RECRUITING

Des Moines, Iowa, 50309, United States
UI Health Care Mission Cancer and Blood - Laurel Clinic
RECRUITING

Des Moines, Iowa, 50314, United States
UI Health Care Mission Cancer and Blood - Waukee Clinic
RECRUITING

Waukee, Iowa, 50263, United States
UI Health Care Mission Cancer and Blood - West Des Moines Clinic
RECRUITING

Clive, Iowa, 50325, United States
UI Healthcare Mission Cancer and Blood - Fort Dodge
RECRUITING

Fort Dodge, Iowa, 50501, United States

Contact Email: •••••@•••••
UI Healthcare Mission Cancer and Blood - Pella
RECRUITING

Pella, Iowa, 50219, United States

Contact Email: •••••@•••••
UNC Lineberger Comprehensive Cancer Center
RECRUITING

Chapel Hill, North Carolina, 27599, United States

Contact Email: •••••@•••••
UW Cancer Center at ProHealth Care
RECRUITING

Waukesha, Wisconsin, 53188, United States
United Hospital
RECRUITING

Saint Paul, Minnesota, 55102, United States
University Health Truman Medical Center
RECRUITING

Kansas City, Missouri, 64108, United States
University of Illinois
RECRUITING

Chicago, Illinois, 60612, United States
University of Kansas Cancer Center
RECRUITING

Kansas City, Kansas, 66160, United States
University of Kansas Cancer Center - Briarcliff
RECRUITING

Kansas City, Missouri, 64116, United States
University of Kansas Cancer Center - Lee's Summit
RECRUITING

Lee's Summit, Missouri, 64064, United States
University of Kansas Cancer Center - North
RECRUITING

Kansas City, Missouri, 64154, United States
University of Kansas Cancer Center-Overland Park
RECRUITING

Overland Park, Kansas, 66210, United States
University of Kansas Health System Saint Francis Campus
RECRUITING

Topeka, Kansas, 66606, United States
University of Kansas Hospital-Westwood Cancer Center
RECRUITING

Westwood, Kansas, 66205, United States
University of Michigan Health - Sparrow Lansing
RECRUITING

Lansing, Michigan, 48912, United States
University of Oklahoma Health Sciences Center
RECRUITING

Oklahoma City, Oklahoma, 73104, United States
University of Rochester
RECRUITING

Rochester, New York, 14642, United States
UofL Health Medical Center Northeast
RECRUITING

Louisville, Kentucky, 40245, United States

Contact Email: •••••@•••••
Washington University School of Medicine
RECRUITING

St Louis, Missouri, 63110, United States

Contact Email: •••••@•••••
William S Middleton VA Medical Center
RECRUITING

Madison, Wisconsin, 53705, United States
Wilmot Cancer Institute at Webster
RECRUITING

Webster, New York, 14580, United States

Contact Email: •••••@•••••

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