Can a Two-Drug combo wipe out hidden leukemia cells?
NCT ID NCT07734038
First seen Jul 29, 2026 · Last updated Jul 30, 2026 · Updated 1 time
Summary
This phase 2 trial is testing whether combining venetoclax and zanubrutinib can drive chronic lymphocytic leukemia (CLL) or small lymphocytic lymphoma (SLL) into deep remission. The study enrolls adults who either have not been treated before or whose cancer returned at least two years after finishing initial therapy. Participants receive both drugs for up to 24 cycles, and researchers measure whether cancer cells become undetectable in the blood.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- a combination of venetoclax and zanubrutinib
- What this could lead to
- If successful, this combination could offer a more effective, time-limited treatment for CLL/SLL, potentially achieving deep remission without continuous therapy.
- What could go wrong
- This is a phase 2 trial, so results are still uncertain. The combination may cause side effects or fail to produce lasting remission in many patients.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
Email: •••••@•••••
Locations
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Ohio State University Comprehensive Cancer Center
Columbus, Ohio, 43210, United States
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