CHRONIC LYMPHOCYTIC LEUKEMIA
Clinical trials for CHRONIC LYMPHOCYTIC LEUKEMIA explained in plain language.
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Can a vaccine series shield CLL patients from pneumonia?
⭐️ VACCINE ⭐️ Recruiting nowThis study tests whether a two-shot pneumonia vaccine series (PCV20 and PPSV23) can help people with chronic lymphocytic leukemia (CLL) build a stronger immune defense against pneumococcal infections. About 61 adults with CLL who have not yet had treatment, or who are on a specif…
Matched conditions: CHRONIC LYMPHOCYTIC LEUKEMIA
Phase: PHASE2 • Sponsor: University of Utah • Aim: ⭐️ VACCINE ⭐️
Last updated Jun 27, 2026 12:06 UTC
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Should High-Risk CLL patients start treatment early? major trial aims to find out
Disease control Recruiting nowThis phase 3 trial compares starting treatment with venetoclax and obinutuzumab right away versus waiting until symptoms appear in people with newly diagnosed, high-risk chronic lymphocytic leukemia or small lymphocytic lymphoma. About 247 participants will be randomly assigned t…
Matched conditions: CHRONIC LYMPHOCYTIC LEUKEMIA
Phase: PHASE3 • Sponsor: National Cancer Institute (NCI) • Aim: Disease control
Last updated Jul 01, 2026 23:00 UTC
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New pill nemtabrutinib takes on standard blood cancer drugs in major trial
Disease control Recruiting nowThis phase 3 trial is testing a new oral drug, nemtabrutinib, against two standard targeted therapies (ibrutinib or acalabrutinib) in 1,200 people with untreated chronic lymphocytic leukemia or small lymphocytic lymphoma. The goal is to see if nemtabrutinib works at least as well…
Matched conditions: CHRONIC LYMPHOCYTIC LEUKEMIA
Phase: PHASE3 • Sponsor: Merck Sharp & Dohme LLC • Aim: Disease control
Last updated Jun 28, 2026 00:00 UTC
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New drug pirtobrutinib tested for Long-Term safety in blood cancers
Disease control Recruiting nowThis study is checking the long-term safety of the drug pirtobrutinib in people with chronic lymphocytic leukemia (CLL) or small lymphocytic lymphoma (SLL) who have already been treated with other drugs. About 150 adults who completed a previous pirtobrutinib study can join. They…
Matched conditions: CHRONIC LYMPHOCYTIC LEUKEMIA
Phase: PHASE4 • Sponsor: Eli Lilly and Company • Aim: Disease control
Last updated Jun 27, 2026 14:03 UTC
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New drug combo aims to make stem cell transplants safer for blood cancer patients
Disease control Recruiting nowThis Phase 2 trial is testing a stem cell transplant from a donor for people with various blood cancers and bone marrow disorders. The transplant uses strong chemotherapy or radiation to wipe out the diseased marrow, then replaces it with healthy donor cells. A new combination of…
Matched conditions: CHRONIC LYMPHOCYTIC LEUKEMIA
Phase: PHASE2 • Sponsor: Masonic Cancer Center, University of Minnesota • Aim: Disease control
Last updated Jun 27, 2026 14:03 UTC
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New combo aims to put CLL into deep remission and let patients stop treatment
Disease control Recruiting nowThis phase 2 trial is testing two targeted drugs, zanubrutinib and obinutuzumab, in people with previously untreated chronic lymphocytic leukemia (CLL) or small lymphocytic lymphoma (SLL). The goal is to see if starting obinutuzumab at different times leads to deep remission wher…
Matched conditions: CHRONIC LYMPHOCYTIC LEUKEMIA
Phase: PHASE2 • Sponsor: PETHEMA Foundation • Aim: Disease control
Last updated Jun 27, 2026 14:03 UTC
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New combo aims to halt early blood cancer before it worsens
Disease control Recruiting nowThis study tests whether a combination of two drugs, acalabrutinib and obinutuzumab, can eliminate signs of cancer in patients with early-stage chronic lymphocytic leukemia or small lymphocytic lymphoma who are at high risk of progression. About 120 participants will be randomly …
Matched conditions: CHRONIC LYMPHOCYTIC LEUKEMIA
Phase: PHASE2 • Sponsor: Mayo Clinic • Aim: Disease control
Last updated Jun 27, 2026 14:02 UTC
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New hope for Tough-to-Treat blood cancers: experimental pill takes on CLL and SLL
Disease control Recruiting nowThis Phase 3 trial is testing an experimental oral drug called BGB-16673 against standard treatments for people with chronic lymphocytic leukemia (CLL) or small lymphocytic lymphoma (SLL) whose cancer has already been treated with two types of targeted therapy (BTK and BCL2 inhib…
Matched conditions: CHRONIC LYMPHOCYTIC LEUKEMIA
Phase: PHASE3 • Sponsor: BeOne Medicines • Aim: Disease control
Last updated Jun 27, 2026 14:01 UTC
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New hope in blood cancer battle: Next-Gen drug tested against standard therapy
Disease control Recruiting nowThis study tests whether a newer drug called pirtobrutinib works better than the current standard drug ibrutinib for people with chronic lymphocytic leukemia or small lymphocytic lymphoma. About 737 adults who need treatment for their cancer will be randomly assigned to receive o…
Matched conditions: CHRONIC LYMPHOCYTIC LEUKEMIA
Phase: PHASE3 • Sponsor: Loxo Oncology, Inc. • Aim: Disease control
Last updated Jun 27, 2026 14:00 UTC
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New hope for Tough-to-Treat blood cancers: phase 3 trial launches
Disease control Recruiting nowThis study compares a new drug, BGB-16673, to an existing one, pirtobrutinib, in people whose chronic lymphocytic leukemia (CLL) or small lymphocytic lymphoma (SLL) has come back or stopped responding to prior treatment. About 500 adults will be randomly assigned to one of the tw…
Matched conditions: CHRONIC LYMPHOCYTIC LEUKEMIA
Phase: PHASE3 • Sponsor: BeOne Medicines • Aim: Disease control
Last updated Jun 27, 2026 14:00 UTC
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New drug aims to wipe out cancer protein in Tough-to-Treat blood cancers
Disease control Recruiting nowThis study tests a new oral drug, BGB-16673, designed to destroy a protein called BTK that helps certain blood cancers grow. The trial includes about 645 people with various B-cell cancers (like lymphoma and leukemia) that have come back or not responded to prior treatments. The …
Matched conditions: CHRONIC LYMPHOCYTIC LEUKEMIA
Phase: PHASE1, PHASE2 • Sponsor: BeOne Medicines • Aim: Disease control
Last updated Jun 27, 2026 14:00 UTC
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New pill combo aims to outperform current standard in CLL
Disease control Recruiting nowThis phase 3 trial is testing whether a new combination of two oral drugs, sonrotoclax and zanubrutinib, works better than the current standard combination (venetoclax plus acalabrutinib) for people with untreated chronic lymphocytic leukemia (CLL). About 500 adults who have not …
Matched conditions: CHRONIC LYMPHOCYTIC LEUKEMIA
Phase: PHASE3 • Sponsor: BeOne Medicines • Aim: Disease control
Last updated Jun 27, 2026 14:00 UTC
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New combo aims to beat standard CLL therapy in older patients
Disease control Recruiting nowThis Phase 3 trial compares a fixed-duration combination of zanubrutinib and sonrotoclax against continuous zanubrutinib alone in older patients with untreated chronic lymphocytic leukemia or small lymphocytic lymphoma. The study will enroll 466 participants to see if the combo i…
Matched conditions: CHRONIC LYMPHOCYTIC LEUKEMIA
Phase: PHASE3 • Sponsor: Alliance for Clinical Trials in Oncology • Aim: Disease control
Last updated Jun 27, 2026 14:00 UTC
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Could a lower dose of a transplant drug be better for blood cancer patients?
Disease control Recruiting nowThis study is testing whether a lower dose of the drug cyclophosphamide, given after a stem cell transplant, can prevent graft-versus-host disease (a common complication where donor cells attack the patient's body) while still being effective. The trial involves 260 adults with b…
Matched conditions: CHRONIC LYMPHOCYTIC LEUKEMIA
Phase: PHASE1, PHASE2 • Sponsor: National Cancer Institute (NCI) • Aim: Disease control
Last updated Jun 27, 2026 13:07 UTC
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New drug duo aims to deepen leukemia remission
Disease control Recruiting nowThis study tests whether adding emavusertib to a standard targeted therapy (zanubrutinib) can improve outcomes for people with chronic lymphocytic leukemia (CLL) and other B-cell cancers. About 108 adults with CLL who have already received some treatment will take both drugs. The…
Matched conditions: CHRONIC LYMPHOCYTIC LEUKEMIA
Phase: PHASE2 • Sponsor: Curis, Inc. • Aim: Disease control
Last updated Jun 27, 2026 13:07 UTC
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New dosing strategy aims to reduce dangerous side effect in blood cancer treatment
Disease control Recruiting nowThis study tests new ways to give the drug sonrotoclax to adults with chronic lymphocytic leukemia or mantle cell lymphoma. The goal is to find a dosing schedule that lowers the risk of tumor lysis syndrome, a serious side effect. About 258 participants will be enrolled to check …
Matched conditions: CHRONIC LYMPHOCYTIC LEUKEMIA
Phase: PHASE1, PHASE2 • Sponsor: BeOne Medicines • Aim: Disease control
Last updated Jun 27, 2026 13:04 UTC
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New hope for blood cancer patients: experimental combo enters final testing phase
Disease control Recruiting nowThis study tests whether a new drug, sonrotoclax, combined with an antibody therapy works better than the current standard treatment for adults with chronic lymphocytic leukemia or small lymphocytic lymphoma that has come back or stopped responding to prior therapy. About 630 par…
Matched conditions: CHRONIC LYMPHOCYTIC LEUKEMIA
Phase: PHASE3 • Sponsor: BeOne Medicines • Aim: Disease control
Last updated Jun 27, 2026 13:03 UTC
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New hope for tough blood cancers? early trial launches
Disease control Recruiting nowThis early-stage trial is testing an experimental drug called JNJ-95804306 in people with blood cancers like leukemia that have come back or not responded to standard treatments. The study has two parts: first, finding a safe dose, and then checking if the drug shrinks tumors whe…
Matched conditions: CHRONIC LYMPHOCYTIC LEUKEMIA
Phase: PHASE1 • Sponsor: Janssen Research & Development, LLC • Aim: Disease control
Last updated Jun 27, 2026 13:03 UTC
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Blood cancer drug ibrutinib gets Long-Term safety check in 700-Patient study
Disease control Recruiting nowThis study offers continued access to the drug ibrutinib for up to 700 people with certain blood cancers (like CLL, lymphoma, and Waldenstrom macroglobulinemia) who are already taking it and benefiting. Researchers will track side effects and how the disease changes over time. Th…
Matched conditions: CHRONIC LYMPHOCYTIC LEUKEMIA
Phase: PHASE3 • Sponsor: Janssen Research & Development, LLC • Aim: Disease control
Last updated Jun 27, 2026 13:03 UTC
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New CAR-T therapy aims to tackle tough blood cancers
Disease control Recruiting nowThis early-phase study tests a new type of CAR-T cell therapy for people with certain blood cancers (like leukemia and lymphoma) that have not responded to standard treatments. The therapy uses a patient's own immune cells, modified to target and attack cancer cells. The main goa…
Matched conditions: CHRONIC LYMPHOCYTIC LEUKEMIA
Phase: PHASE1 • Sponsor: University of Utah • Aim: Disease control
Last updated Jun 27, 2026 13:02 UTC
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New hope for Hard-to-Treat leukemia: Two-Drug combo enters human trials
Disease control Recruiting nowThis early-stage trial is testing two drugs, mosunetuzumab and venetoclax, in people with chronic lymphocytic leukemia (CLL) that has come back or stopped responding to treatment. Mosunetuzumab is given as a shot under the skin, and venetoclax is a daily pill. The study will chec…
Matched conditions: CHRONIC LYMPHOCYTIC LEUKEMIA
Phase: PHASE1 • Sponsor: Hoffmann-La Roche • Aim: Disease control
Last updated Jun 27, 2026 13:00 UTC
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New drug aims to keep leukemia at bay after first treatment
Disease control Recruiting nowThis Phase 3 trial is testing whether the drug surovatamig can help people with a specific type of chronic lymphocytic leukemia (CLL) or small lymphocytic lymphoma (SLL) stay in remission longer after their first round of treatment. About 420 participants will either receive suro…
Matched conditions: CHRONIC LYMPHOCYTIC LEUKEMIA
Phase: PHASE3 • Sponsor: AstraZeneca • Aim: Disease control
Last updated Jun 27, 2026 13:00 UTC
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Custom-Made vaccine takes on untreated leukemia in early trial
Disease control Recruiting nowThis early-phase study tests a personalized neoantigen vaccine (NeoVax) in 15 people with untreated chronic lymphocytic leukemia (CLL) who have a specific genetic marker (IGHV unmutated). The vaccine is designed to train the immune system to attack each person's unique cancer cel…
Matched conditions: CHRONIC LYMPHOCYTIC LEUKEMIA
Phase: PHASE1 • Sponsor: Dana-Farber Cancer Institute • Aim: Disease control
Last updated Jun 27, 2026 12:38 UTC
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New triple therapy aims to wipe out hidden CLL cells
Disease control Recruiting nowThis study tests a combination of three drugs (zanubrutinib, obinutuzumab, and sonrotoclax) in people with previously untreated chronic lymphocytic leukemia (CLL) or small lymphocytic lymphoma (SLL). The goal is to see if the treatment can make the cancer undetectable in the bloo…
Matched conditions: CHRONIC LYMPHOCYTIC LEUKEMIA
Phase: PHASE2 • Sponsor: Massachusetts General Hospital • Aim: Disease control
Last updated Jun 27, 2026 12:36 UTC
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New hope for Tough-to-Treat blood cancers: pirtobrutinib trial launches
Disease control Recruiting nowThis study tests three different doses of a drug called pirtobrutinib in people with chronic lymphocytic leukemia (CLL) or small lymphocytic lymphoma (SLL) whose cancer came back or didn't respond after treatment with a BTK inhibitor. About 249 participants will take part. The go…
Matched conditions: CHRONIC LYMPHOCYTIC LEUKEMIA
Phase: PHASE2 • Sponsor: Loxo Oncology, Inc. • Aim: Disease control
Last updated Jun 27, 2026 12:35 UTC
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New drug duo takes on rare, deadly lymphoma
Disease control Recruiting nowThis phase II trial tests whether combining nemtabrutinib (a targeted drug) with pembrolizumab (an immunotherapy) can shrink tumors in 32 people with Richter transformation, an aggressive lymphoma that arises from chronic lymphocytic leukemia. Participants must have failed or be …
Matched conditions: CHRONIC LYMPHOCYTIC LEUKEMIA
Phase: PHASE2 • Sponsor: Roswell Park Cancer Institute • Aim: Disease control
Last updated Jun 27, 2026 12:35 UTC
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New trial aims to tame transplant complications in blood cancer patients
Disease control Recruiting nowThis phase II trial tests different drug combinations to prevent graft-versus-host disease (GVHD) in 400 blood cancer patients receiving stem cell transplants from unrelated donors. Participants will receive either thymoglobulin or a combination of cyclophosphamide with other imm…
Matched conditions: CHRONIC LYMPHOCYTIC LEUKEMIA
Phase: PHASE2 • Sponsor: University of Birmingham • Aim: Disease control
Last updated Jun 27, 2026 12:29 UTC
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New hope for tough blood cancers: LP-118 trial launches
Disease control Recruiting nowThis early-stage study tests a new oral drug, LP-118, in up to 100 adults with blood cancers like lymphoma, leukemia, or myeloma that returned or didn't respond to prior therapy. The main goals are to find the safest dose and see if the drug can shrink tumors or slow the disease.…
Matched conditions: CHRONIC LYMPHOCYTIC LEUKEMIA
Phase: PHASE1 • Sponsor: Newave Pharmaceutical Inc • Aim: Disease control
Last updated Jun 27, 2026 12:29 UTC
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New triple therapy aims to control CLL without lifelong treatment
Disease control Recruiting nowThis study tests whether a time-limited combination of three drugs (pirtobrutinib, venetoclax, and obinutuzumab) is safe and effective for people with untreated chronic lymphocytic leukemia (CLL) or Richter transformation (RT). About 60 adults with good organ function and perform…
Matched conditions: CHRONIC LYMPHOCYTIC LEUKEMIA
Phase: PHASE2 • Sponsor: M.D. Anderson Cancer Center • Aim: Disease control
Last updated Jun 27, 2026 12:26 UTC
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New combo therapy aims to speed up treatment for blood cancer patients
Disease control Recruiting nowThis study tests a faster, hospital-based dose increase of the drug sonrotoclax for people with chronic lymphocytic leukemia (CLL), small lymphocytic lymphoma (SLL), or mantle cell lymphoma (MCL) that is new, has returned, or hasn't responded to treatment. Participants first rece…
Matched conditions: CHRONIC LYMPHOCYTIC LEUKEMIA
Phase: PHASE2 • Sponsor: Fred Hutchinson Cancer Center • Aim: Disease control
Last updated Jun 27, 2026 12:23 UTC
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New drug may cut infection risk after Half-Matched stem cell transplants
Disease control Recruiting nowThis study tests whether a drug called sargramostim can help restore white blood cells as quickly as the standard drug (G-CSF) after a half-matched stem cell transplant for blood cancers, while possibly lowering the risk of serious infections. About 38 adults with blood cancers l…
Matched conditions: CHRONIC LYMPHOCYTIC LEUKEMIA
Phase: PHASE2 • Sponsor: Northside Hospital, Inc. • Aim: Disease control
Last updated Jun 27, 2026 12:07 UTC
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New combo therapy aims to outsmart tough leukemia
Disease control Recruiting nowThis phase 2 trial tests a combination of three drugs (venetoclax, obinutuzumab, and acalabrutinib) in 40 people with relapsed or refractory CLL or SLL. The treatment is adjusted based on how well the cancer responds (measured by minimal residual disease). The main goal is to see…
Matched conditions: CHRONIC LYMPHOCYTIC LEUKEMIA
Phase: PHASE2 • Sponsor: Massachusetts General Hospital • Aim: Disease control
Last updated Jun 27, 2026 12:06 UTC
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New CLL trial aims to reduce Life-Threatening side effect of cancer drugs
Disease control Recruiting nowThis phase 3 trial tests different ways to start venetoclax combined with obinutuzumab or acalabrutinib in 170 adults with untreated chronic lymphocytic leukemia (CLL). The goal is to find the safest ramp-up schedule to prevent tumor lysis syndrome, a dangerous side effect. Parti…
Matched conditions: CHRONIC LYMPHOCYTIC LEUKEMIA
Phase: PHASE3 • Sponsor: AbbVie • Aim: Disease control
Last updated Jun 27, 2026 12:05 UTC
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Off-the-Shelf CAR-T cells take on tough blood cancers
Disease control Recruiting nowThis study tests a new CAR-T therapy made from donor cells, so it's ready to use without waiting for a patient's own cells to be modified. It targets two proteins on cancer cells to lower the chance of the cancer coming back. About 178 adults with relapsed or refractory B-cell ly…
Matched conditions: CHRONIC LYMPHOCYTIC LEUKEMIA
Phase: PHASE1, PHASE2 • Sponsor: AvenCell Therapeutics, Inc. • Aim: Disease control
Last updated Jun 27, 2026 12:03 UTC
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Gene therapy injection takes aim at Hard-to-Treat blood cancers
Disease control Recruiting nowThis early-stage trial tests a single-dose gene therapy called VNX-101 for people with certain blood cancers (like leukemia or lymphoma) that have returned or not responded to standard treatment. The therapy delivers instructions to the body to make a protein that helps immune ce…
Matched conditions: CHRONIC LYMPHOCYTIC LEUKEMIA
Phase: PHASE1, PHASE2 • Sponsor: Vironexis Biotherapeutics Inc. • Aim: Disease control
Last updated Jun 27, 2026 12:02 UTC
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Engineered immune cells get a metabolic boost to fight blood cancers
Disease control Recruiting nowThis early-phase trial is testing a new version of CAR T-cell therapy that has been modified to improve its energy use, potentially making the cells more effective. It is for adults with certain types of B-cell lymphoma or chronic lymphocytic leukemia that have come back or not r…
Matched conditions: CHRONIC LYMPHOCYTIC LEUKEMIA
Phase: PHASE1, PHASE2 • Sponsor: Medical University of South Carolina • Aim: Disease control
Last updated Jun 27, 2026 12:01 UTC
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New pill shows promise for tough blood cancers
Disease control Recruiting nowThis study tests a new drug called APG-2575 in people whose chronic lymphocytic leukemia (CLL) or small lymphocytic lymphoma (SLL) has come back or stopped responding to other treatments. About 75 adults will take the drug alone to see if it can shrink tumors and control the dise…
Matched conditions: CHRONIC LYMPHOCYTIC LEUKEMIA
Phase: PHASE2 • Sponsor: Ascentage Pharma Group Inc. • Aim: Disease control
Last updated Jun 27, 2026 12:01 UTC
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New hope for rare, aggressive blood cancer: 3-Drug cocktail targets richter transformation
Disease control Recruiting nowThis study tests a combination of three drugs (acalabrutinib, venetoclax, and durvalumab) in people with Richter transformation, a rare and fast-growing lymphoma that develops from chronic lymphocytic leukemia (CLL). The goal is to control the disease and improve survival. About …
Matched conditions: CHRONIC LYMPHOCYTIC LEUKEMIA
Phase: PHASE2 • Sponsor: Mayo Clinic • Aim: Disease control
Last updated Jun 27, 2026 12:00 UTC
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New triple therapy aims to deepen remission in untreated CLL
Disease control Recruiting nowThis study tests whether adding a newer drug, epcoritamab, to a standard two-drug combination can improve outcomes for people with untreated chronic lymphocytic leukemia (CLL) or small lymphocytic lymphoma (SLL). The standard combo (venetoclax + obinutuzumab) is already effective…
Matched conditions: CHRONIC LYMPHOCYTIC LEUKEMIA
Phase: PHASE2 • Sponsor: City of Hope Medical Center • Aim: Disease control
Last updated Jun 27, 2026 11:01 UTC
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Blood cancer drug safety tracked in Long-Term study
Disease control Recruiting nowThis study looks at the long-term safety of the drug pirtobrutinib in people with chronic lymphocytic leukemia or non-Hodgkin lymphoma. About 787 participants who completed an earlier pirtobrutinib study can join to keep receiving treatment or have follow-up visits. The main goal…
Matched conditions: CHRONIC LYMPHOCYTIC LEUKEMIA
Phase: PHASE4 • Sponsor: Eli Lilly and Company • Aim: Disease control
Last updated Jun 27, 2026 09:10 UTC
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Blood cancer drug pirtobrutinib tested for Long-Term safety in ongoing study
Disease control Recruiting nowThis study looks at the long-term safety of the drug pirtobrutinib in people with chronic lymphocytic leukemia (CLL) or non-Hodgkin lymphoma (NHL) who were already in a previous trial. About 279 participants will continue their treatment or follow-up visits. The main goal is to t…
Matched conditions: CHRONIC LYMPHOCYTIC LEUKEMIA
Phase: PHASE4 • Sponsor: Eli Lilly and Company • Aim: Disease control
Last updated Jun 27, 2026 09:09 UTC
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New combo therapy takes on tough lymphoma
Disease control Recruiting nowThis study tests a combination of two treatments—zanubrutinib (a targeted drug) and lisocabtagene maraleucel (a CAR T-cell therapy)—for people with Richter's syndrome, an aggressive lymphoma that can develop from chronic lymphocytic leukemia. The goal is to see if this combo can …
Matched conditions: CHRONIC LYMPHOCYTIC LEUKEMIA
Phase: PHASE2 • Sponsor: Aseel Alsouqi • Aim: Disease control
Last updated Jun 27, 2026 09:09 UTC
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Can blood pressure control save hearts in cancer patients?
Disease control Recruiting nowThis study at Mayo Clinic looks at how often high blood pressure happens in patients with certain blood cancers (like CLL or lymphoma) who are taking a type of targeted drug called a BTK inhibitor. It will track 100 patients over a year to see if managing blood pressure well can …
Matched conditions: CHRONIC LYMPHOCYTIC LEUKEMIA
Sponsor: Mayo Clinic • Aim: Disease control
Last updated Jun 27, 2026 09:08 UTC
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New combo therapy aims to wipe out CLL cells in untreated patients
Disease control Recruiting nowThis phase 2 trial tests two different drug combinations in people with untreated chronic lymphocytic leukemia (CLL). Participants first take acalabrutinib alone, then are randomly assigned to add either obinutuzumab or venetoclax. The goal is to see which combination better clea…
Matched conditions: CHRONIC LYMPHOCYTIC LEUKEMIA
Phase: PHASE2 • Sponsor: Ohio State University Comprehensive Cancer Center • Aim: Disease control
Last updated Jun 27, 2026 09:06 UTC
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New drug cocktail aims to crush resistant leukemia
Disease control Recruiting nowThis phase 2 trial tests whether combining pirtobrutinib and venetoclax can eliminate signs of cancer in patients with chronic lymphocytic leukemia (CLL) or small lymphocytic lymphoma (SLL) that has stopped responding to standard BTK inhibitors. About 30 adults currently taking i…
Matched conditions: CHRONIC LYMPHOCYTIC LEUKEMIA
Phase: PHASE2 • Sponsor: Kerry Rogers • Aim: Disease control
Last updated Jun 27, 2026 09:05 UTC
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New pill takes on tough blood cancers in early trial
Disease control Recruiting nowThis early-phase study is testing an experimental oral drug called LP-168 in about 60 people with several types of B-cell blood cancers that have come back or not responded to prior treatments. The main goals are to find the safest dose and to see how the drug behaves in the body…
Matched conditions: CHRONIC LYMPHOCYTIC LEUKEMIA
Phase: PHASE1 • Sponsor: Newave Pharmaceutical Inc • Aim: Disease control
Last updated Jun 27, 2026 09:04 UTC
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New Three-Drug cocktail aims to outsmart tough leukemia
Disease control Recruiting nowThis study tests a new combination of three drugs—roginolisib, venetoclax, and rituximab—in people with chronic lymphocytic leukemia (CLL) that has come back or not responded to prior treatments. The goal is to see if the combination is safe and can wipe out leukemia cells more e…
Matched conditions: CHRONIC LYMPHOCYTIC LEUKEMIA
Phase: PHASE1, PHASE2 • Sponsor: Jennifer R. Brown, MD, PhD • Aim: Disease control
Last updated Jun 27, 2026 09:04 UTC
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New drug SGR-1505 enters early human testing for blood cancers
Disease control Recruiting nowThis early-phase trial tests a new drug, SGR-1505, in about 98 adults with various B-cell blood cancers (like lymphoma or leukemia) that have not responded to other treatments. The main goals are to find the safest dose and understand side effects. Participants will receive the d…
Matched conditions: CHRONIC LYMPHOCYTIC LEUKEMIA
Phase: PHASE1 • Sponsor: Schrödinger, Inc. • Aim: Disease control
Last updated Jun 27, 2026 09:04 UTC
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Tailored transplant doses aim to beat blood cancer
Disease control Recruiting nowThis phase 2 trial tests a personalized approach to stem cell transplants for people with blood cancers like leukemia and lymphoma. Instead of a one-size-fits-all chemotherapy and radiation regimen, doctors adjust the doses based on each patient's risk. The goal is to improve the…
Matched conditions: CHRONIC LYMPHOCYTIC LEUKEMIA
Phase: PHASE2 • Sponsor: University of California, Irvine • Aim: Disease control
Last updated Jun 27, 2026 09:02 UTC
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Off-the-Shelf CAR t cells take on tough lymphomas and leukemias
Disease control Recruiting nowThis early-phase trial is testing a new type of CAR T cell therapy called Azer-cel, which is made from healthy donor cells rather than the patient's own cells. It aims to treat adults with relapsed or refractory non-Hodgkin lymphoma, B-cell acute lymphoblastic leukemia, and relat…
Matched conditions: CHRONIC LYMPHOCYTIC LEUKEMIA
Phase: PHASE1 • Sponsor: Imugene Limited • Aim: Disease control
Last updated Jun 27, 2026 09:02 UTC
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Cord blood cells engineered to fight Hard-to-Treat blood cancers
Disease control Recruiting nowThis study tests a new treatment using immune cells (NK cells) from donated cord blood that are engineered to target a protein called CD5 found on certain cancer cells. The treatment is given after chemotherapy to prepare the body, and the goal is to see if it is safe and effecti…
Matched conditions: CHRONIC LYMPHOCYTIC LEUKEMIA
Phase: PHASE1, PHASE2 • Sponsor: M.D. Anderson Cancer Center • Aim: Disease control
Last updated Jun 27, 2026 09:01 UTC
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Suicide-Gene t cells aim to stop blood cancer relapse
Disease control Recruiting nowThis early-phase trial tests whether infusing specially designed immune cells can prevent blood cancer from coming back after a stem cell transplant. The cells target a specific protein (HLA-DPB1*04:01) found on many cancer cells and include a 'suicide switch' to turn them off if…
Matched conditions: CHRONIC LYMPHOCYTIC LEUKEMIA
Phase: PHASE1 • Sponsor: Nantes University Hospital • Aim: Disease control
Last updated Jun 27, 2026 08:15 UTC
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New combo aims to control CLL in just one year
Disease control Recruiting nowThis study tests a one-year treatment plan using two drugs, pirtobrutinib and obinutuzumab, for people with chronic lymphocytic leukemia (CLL) or small lymphocytic lymphoma (SLL) who have not had treatment before. The goal is to see if this fixed-duration therapy can control the …
Matched conditions: CHRONIC LYMPHOCYTIC LEUKEMIA
Phase: PHASE2 • Sponsor: Inhye Ahn • Aim: Disease control
Last updated Jun 27, 2026 08:13 UTC
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New drug ABBV-319 takes aim at Hard-to-Treat blood cancers
Disease control Recruiting nowThis early-stage trial tests an investigational drug called ABBV-319 in about 154 adults with certain B-cell cancers (diffuse large B-cell lymphoma, follicular lymphoma, or chronic lymphocytic leukemia) that have returned or not responded to standard treatments. The study has two…
Matched conditions: CHRONIC LYMPHOCYTIC LEUKEMIA
Phase: PHASE1 • Sponsor: AbbVie • Aim: Disease control
Last updated Jun 27, 2026 08:12 UTC
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New CAR T-Cell therapy targets tough blood cancers
Disease control Recruiting nowThis study tests a new treatment called SHB-04-CD22, which uses a patient's own immune cells (T-cells) engineered to find and attack cancer cells that have a protein called CD22. It is for children and adults (ages 1-80) with B-cell cancers that have come back or not responded to…
Matched conditions: CHRONIC LYMPHOCYTIC LEUKEMIA
Phase: PHASE1, PHASE2 • Sponsor: Sheba Medical Center • Aim: Disease control
Last updated Jun 27, 2026 08:11 UTC
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New pill aims to fight advanced lymphoma when other treatments fail
Disease control Recruiting nowThis early-stage trial tests an oral drug called AUR112 in 40 adults with relapsed advanced lymphoma. The main goals are to check safety, find the right dose, and see how the drug moves through the body. It is the first time this drug is being tested in humans.
Matched conditions: CHRONIC LYMPHOCYTIC LEUKEMIA
Phase: PHASE1 • Sponsor: Aurigene Discovery Technologies Limited • Aim: Disease control
Last updated Jun 27, 2026 08:10 UTC
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Second chance: new combo targets relapsed CLL after venetoclax fails
Disease control Recruiting nowThis Phase 2 trial tests a combination of two drugs, venetoclax and acalabrutinib, in 60 adults with chronic lymphocytic leukemia (CLL) whose cancer returned after initial treatment with venetoclax plus an antibody. Participants first take acalabrutinib alone for 2 cycles, then a…
Matched conditions: CHRONIC LYMPHOCYTIC LEUKEMIA
Phase: PHASE2 • Sponsor: Stichting Hemato-Oncologie voor Volwassenen Nederland • Aim: Disease control
Last updated Jun 27, 2026 08:09 UTC
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New mRNA CAR-T therapy aims to tackle tough blood cancers
Disease control Recruiting nowThis study tests a new type of CAR-T cell therapy that uses mRNA to target two proteins (CD19 and CD20) on cancer cells. It is for people with B-cell lymphoma or leukemia that has come back or not responded to treatment. The goal is to see if it is safe and effective, with up to …
Matched conditions: CHRONIC LYMPHOCYTIC LEUKEMIA
Phase: PHASE2 • Sponsor: Daihong Liu • Aim: Disease control
Last updated Jun 27, 2026 08:09 UTC
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Supercharged immune cells take on blood cancers in new trial
Disease control Recruiting nowThis study tests a new treatment for people with advanced B-cell lymphoma or leukemia that has returned or not improved after standard therapy. Researchers take a patient's own T-cells, add a special receptor (CAR) that targets the CD19 protein on cancer cells, and also add extra…
Matched conditions: CHRONIC LYMPHOCYTIC LEUKEMIA
Phase: PHASE1 • Sponsor: Baylor College of Medicine • Aim: Disease control
Last updated Jun 27, 2026 08:08 UTC
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Could taking drug holidays improve CLL treatment?
Disease control Recruiting nowThis study tests whether taking the targeted drug venetoclax on an intermittent schedule (with breaks) works as well as taking it continuously, when combined with acalabrutinib, in people with previously untreated chronic lymphocytic leukemia or small lymphocytic lymphoma. About …
Matched conditions: CHRONIC LYMPHOCYTIC LEUKEMIA
Phase: PHASE2 • Sponsor: Zulfa Omer • Aim: Disease control
Last updated Jun 27, 2026 08:08 UTC
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New combo therapy aims to wipe out hidden leukemia cells
Disease control Recruiting nowThis study tests whether adding the drug epcoritamab after standard treatment can make chronic lymphocytic leukemia (CLL) or small lymphocytic lymphoma (SLL) disappear more completely. About 22 adults who have already received at least 12 months of a BTK inhibitor (acalabrutinib …
Matched conditions: CHRONIC LYMPHOCYTIC LEUKEMIA
Phase: PHASE2 • Sponsor: Zulfa Omer • Aim: Disease control
Last updated Jun 27, 2026 08:08 UTC
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New hope for aggressive blood cancer: drug combo trial opens
Disease control Recruiting nowThis study tests a drug called glofitamab, alone or with other medicines, in people whose chronic lymphocytic leukemia (CLL) has turned into a more aggressive cancer called Richter's transformation. About 70 adults will receive treatment to see if the cancer shrinks or disappears…
Matched conditions: CHRONIC LYMPHOCYTIC LEUKEMIA
Phase: PHASE2 • Sponsor: Christine Ryan • Aim: Disease control
Last updated Jun 27, 2026 08:08 UTC
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Can a bispecific antibody wipe out stubborn CLL cells?
Disease control Recruiting nowThis pilot study tests whether the drug mosunetuzumab, given alone or with a BTK inhibitor, can clear minimal residual disease (tiny amounts of leftover cancer) in people with chronic lymphocytic leukemia (CLL) or small lymphocytic lymphoma (SLL). About 40 participants who have a…
Matched conditions: CHRONIC LYMPHOCYTIC LEUKEMIA
Phase: PHASE1, PHASE2 • Sponsor: Inhye Ahn • Aim: Disease control
Last updated Jun 27, 2026 08:04 UTC
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New pill shows promise for Hard-to-Treat blood cancers
Disease control Recruiting nowThis early-stage trial tests an oral drug called AS-1763 in about 120 adults with chronic lymphocytic leukemia, small lymphocytic lymphoma, or other B-cell non-Hodgkin lymphomas who have already tried at least two other treatments. The study aims to find the safest dose and check…
Matched conditions: CHRONIC LYMPHOCYTIC LEUKEMIA
Phase: PHASE1 • Sponsor: Carna Biosciences, Inc. • Aim: Disease control
Last updated Jun 27, 2026 08:03 UTC
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Could a simple vibration machine help blood cancer patients?
Disease control Recruiting nowThis study tests whether low-intensity mechanical stimulation (LIMS) vibration therapy can help blood cancer patients who are about to receive a stem cell transplant or cell therapy. The vibration board sends gentle waves through the bones, which may stimulate bone growth, improv…
Matched conditions: CHRONIC LYMPHOCYTIC LEUKEMIA
Phase: NA • Sponsor: Roswell Park Cancer Institute • Aim: Disease control
Last updated Jun 27, 2026 08:01 UTC
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Vitamin B3 pill may shield CLL patients from skin cancer
Disease control Recruiting nowThis study tests whether taking nicotinamide (a form of vitamin B3) twice daily for one year can reduce the number of new non-melanoma skin cancers in people with chronic lymphocytic leukemia (CLL) who have already had at least one such skin cancer. About 86 participants will be …
Matched conditions: CHRONIC LYMPHOCYTIC LEUKEMIA
Phase: PHASE2 • Sponsor: University of Utah • Aim: Disease control
Last updated Jun 27, 2026 08:01 UTC
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New combo therapy aims to control blood cancer without a cure
Disease control Recruiting nowThis study tests a new drug combination (ICP-248 plus orelabrutinib) in people with untreated chronic lymphocytic leukemia or small lymphocytic lymphoma. The goal is to see if the combination is safe and tolerable. About 226 adults aged 18 to 80 with measurable disease and a need…
Matched conditions: CHRONIC LYMPHOCYTIC LEUKEMIA
Phase: PHASE2, PHASE3 • Sponsor: Beijing InnoCare Pharma Tech Co., Ltd. • Aim: Disease control
Last updated Jun 27, 2026 07:59 UTC
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New combo therapy aims to wipe out hidden leukemia cells in High-Risk patients
Disease control Recruiting nowThis study is for people with high-risk chronic lymphocytic leukemia (CLL) who have been on ibrutinib or acalabrutinib for at least a year but still have detectable disease. Researchers want to see if adding venetoclax for 12 cycles can clear remaining leukemia cells from the bon…
Matched conditions: CHRONIC LYMPHOCYTIC LEUKEMIA
Phase: PHASE2 • Sponsor: M.D. Anderson Cancer Center • Aim: Disease control
Last updated Jun 27, 2026 07:58 UTC
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New CAR-T therapy aims to tackle tough lymphoma
Disease control Recruiting nowThis early-stage study is testing a new immune cell therapy called CT1190B CAR-T in 27 adults with B-cell non-Hodgkin lymphoma that has come back or not responded to treatment. The therapy involves modifying a patient's own immune cells to better recognize and attack cancer cells…
Matched conditions: CHRONIC LYMPHOCYTIC LEUKEMIA
Phase: PHASE1 • Sponsor: Tongji Hospital • Aim: Disease control
Last updated Jun 27, 2026 07:58 UTC
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New triple therapy shows promise for blood cancer patients
Disease control Recruiting nowThis early-phase study tests whether combining three drugs (tafasitamab, acalabrutinib, and obinutuzumab) is safe and effective for people with untreated chronic lymphocytic leukemia (CLL) or small lymphocytic lymphoma (SLL). The goal is to control the cancer by targeting differe…
Matched conditions: CHRONIC LYMPHOCYTIC LEUKEMIA
Phase: PHASE1 • Sponsor: OHSU Knight Cancer Institute • Aim: Disease control
Last updated Jun 27, 2026 07:56 UTC
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New triple therapy aims to tame relapsed blood cancer
Disease control Recruiting nowThis study tests whether a combination of three drugs—pirtobrutinib, venetoclax, and obinutuzumab—can control relapsed chronic lymphocytic leukemia (CLL) or small lymphocytic lymphoma (SLL). About 40 adults who have had prior treatment will receive this time-limited therapy. The …
Matched conditions: CHRONIC LYMPHOCYTIC LEUKEMIA
Phase: PHASE2 • Sponsor: M.D. Anderson Cancer Center • Aim: Disease control
Last updated Jun 27, 2026 07:56 UTC
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New Two-Step transplant aims to cut deaths in blood cancer patients
Disease control Recruiting nowThis phase 2 trial tests a two-step, lower-intensity transplant method for people with various blood cancers. The goal is to see if this gentler approach reduces the chance of dying from the transplant itself. About 63 participants will receive a combination of radiation, chemoth…
Matched conditions: CHRONIC LYMPHOCYTIC LEUKEMIA
Phase: PHASE2 • Sponsor: Thomas Jefferson University • Aim: Disease control
Last updated Jun 27, 2026 07:56 UTC
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One-Year combo pill strategy may boost CLL remission rates
Disease control Recruiting nowThis study looks at 100 people with chronic lymphocytic leukemia (CLL) or small lymphocytic lymphoma (SLL) who are already taking a BTKi pill (like ibrutinib). Half will keep taking the BTKi alone, while the other half will add a second pill called venetoclax for one year. After …
Matched conditions: CHRONIC LYMPHOCYTIC LEUKEMIA
Phase: PHASE2 • Sponsor: VA Office of Research and Development • Aim: Disease control
Last updated Jun 27, 2026 07:54 UTC
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Can immunoglobulin or antibiotics stop infections in blood cancer patients?
Disease control Recruiting nowThis study compares immunoglobulin (given through a vein or under the skin) with antibiotics to see which better prevents severe infections in people with blood cancers like myeloma, lymphoma, or leukemia who have low antibody levels. About 900 adults will take part. The goal is …
Matched conditions: CHRONIC LYMPHOCYTIC LEUKEMIA
Phase: PHASE2, PHASE3 • Sponsor: Monash University • Aim: Disease control
Last updated Jun 27, 2026 07:54 UTC
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Promising new combo tackles rare leukemia complication
Disease control Recruiting nowThis phase 2 trial is testing whether adding the drug polatuzumab vedotin to standard chemotherapy can improve remission rates in people with Richter's transformation, an aggressive lymphoma that can develop from chronic lymphocytic leukemia (CLL). About 20 adults with confirmed …
Matched conditions: CHRONIC LYMPHOCYTIC LEUKEMIA
Phase: PHASE2 • Sponsor: Weill Medical College of Cornell University • Aim: Disease control
Last updated Jun 27, 2026 07:54 UTC
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New drug cocktail aims to tackle tough lymphoma
Disease control Recruiting nowThis Phase 2 trial tests a combination of the drug linperlisib plus three older drugs (cyclophosphamide, prednisone, and thalidomide) in 180 adults with non-Hodgkin lymphoma that has returned or not responded to treatment. The goal is to see how many patients achieve a complete o…
Matched conditions: CHRONIC LYMPHOCYTIC LEUKEMIA
Phase: PHASE2 • Sponsor: The First Affiliated Hospital with Nanjing Medical University • Aim: Disease control
Last updated Jun 27, 2026 07:52 UTC
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New hope for tough blood cancers? early trial launches
Disease control Recruiting nowThis early-stage study is testing a new biologic drug called CC312 in 44 adults with certain blood cancers (like lymphoma or leukemia) that have returned or not responded to standard treatments. The main goals are to check safety and find the right dose. Participants receive CC31…
Matched conditions: CHRONIC LYMPHOCYTIC LEUKEMIA
Phase: PHASE1 • Sponsor: CytoCares Inc • Aim: Disease control
Last updated Jun 27, 2026 07:51 UTC
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New pill hopes to tackle tough lymphoma
Disease control Recruiting nowThis early-stage trial is testing an experimental drug called LP-168, taken as a pill, in adults with B-cell lymphoma that has come back or not responded to standard treatments. The study aims to find the safest dose and check for side effects in about 200 participants. It is too…
Matched conditions: CHRONIC LYMPHOCYTIC LEUKEMIA
Phase: PHASE1 • Sponsor: Guangzhou Lupeng Pharmaceutical Company LTD. • Aim: Disease control
Last updated Jun 27, 2026 07:51 UTC
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New pill shows promise against blood cancers in early trial
Disease control Recruiting nowThis early-stage study tests an experimental drug called ICP-248, taken as a pill, for people with certain blood cancers (like leukemia or lymphoma). The drug is given alone or with another drug, orelabrutinib. The main goals are to check safety, find the right dose, and see if i…
Matched conditions: CHRONIC LYMPHOCYTIC LEUKEMIA
Phase: PHASE1 • Sponsor: Beijing InnoCare Pharma Tech Co., Ltd. • Aim: Disease control
Last updated Jun 26, 2026 15:15 UTC
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New PET scan tracer could spot hidden blood cancers
Diagnosis Recruiting nowThis early-phase trial is testing a new radioactive imaging agent called 64Cu-LLP2A to see if it can safely and clearly show blood cancers like multiple myeloma and lymphoma on PET/CT scans. The study includes healthy volunteers and patients with these cancers, including those wh…
Matched conditions: CHRONIC LYMPHOCYTIC LEUKEMIA
Phase: EARLY_PHASE1 • Sponsor: Washington University School of Medicine • Aim: Diagnosis
Last updated Jun 27, 2026 14:00 UTC
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New vaccine aims to shield stem cell patients from dangerous virus
Prevention Recruiting nowThis early-phase trial tests a vaccine (CMV-MVA Triplex) given to both stem cell donors and recipients to boost immunity against cytomegalovirus (CMV) and prevent active infection after a half-matched stem cell transplant. About 46 people with various blood cancers will take part…
Matched conditions: CHRONIC LYMPHOCYTIC LEUKEMIA
Phase: PHASE1 • Sponsor: City of Hope Medical Center • Aim: Prevention
Last updated Jul 01, 2026 23:00 UTC
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Poop pills to prevent transplant rejection? new trial tests fecal transplants in blood cancer patients
Prevention Recruiting nowThis study tests whether a fecal microbiota transplant (FMT) can prevent graft-versus-host disease (GvHD) in 150 adults with blood cancers who receive a stem cell transplant. Patients get a single FMT enema within four weeks of transplant. The main goal is to see if FMT improves …
Matched conditions: CHRONIC LYMPHOCYTIC LEUKEMIA
Phase: PHASE2 • Sponsor: University Hospital, Clermont-Ferrand • Aim: Prevention
Last updated Jun 27, 2026 13:04 UTC
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Donor vaccine aims to shield transplant patients from common virus
Prevention Recruiting nowThis phase 2 trial tests a vaccine called CMV-MVA Triplex, given to stem cell donors before they donate. The goal is to boost the donor's immunity against cytomegalovirus (CMV), which can then be passed to the transplant patient. Researchers hope this will prevent CMV infection i…
Matched conditions: CHRONIC LYMPHOCYTIC LEUKEMIA
Phase: PHASE2 • Sponsor: City of Hope Medical Center • Aim: Prevention
Last updated Jun 27, 2026 11:00 UTC
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Yearly shots could shield CLL patients from deadly infections
Prevention Recruiting nowThis study tests whether giving yearly pneumococcal vaccines to people with chronic lymphocytic leukemia (CLL) provides better protection than the standard vaccine given every 5 years. About 80 adults with untreated CLL will receive either the yearly schedule or the standard sche…
Matched conditions: CHRONIC LYMPHOCYTIC LEUKEMIA
Phase: PHASE2 • Sponsor: Seema Bhat • Aim: Prevention
Last updated Jun 27, 2026 08:08 UTC
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Can a tailored exercise and diet plan beat cancer fatigue?
Symptom relief Recruiting nowThis study tests a personalized program combining exercise and nutrition advice to help reduce fatigue in people with indolent (slow-growing) lymphomas, such as chronic lymphocytic leukemia and follicular lymphoma. Participants receive an individualized exercise plan and dietary …
Matched conditions: CHRONIC LYMPHOCYTIC LEUKEMIA
Phase: NA • Sponsor: UNC Lineberger Comprehensive Cancer Center • Aim: Symptom relief
Last updated Jul 01, 2026 23:00 UTC
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New study aims to make allergy testing safer for cancer patients on biologics
Knowledge-focused Recruiting nowThis study is testing how to safely perform skin allergy tests in people receiving biotherapies for cancers and blood disorders. Researchers will find the highest concentration of each biotherapy that does not cause a skin reaction in 9 out of 10 patients. The goal is to establis…
Matched conditions: CHRONIC LYMPHOCYTIC LEUKEMIA
Phase: NA • Sponsor: University Hospital, Angers • Aim: Knowledge-focused
Last updated Jun 27, 2026 14:00 UTC
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New study tracks daily life of leukemia patients on acalabrutinib
Knowledge-focused Recruiting nowThis study measures how people with chronic lymphocytic leukemia feel and function while taking acalabrutinib in everyday life. Researchers will look at quality-of-life scores from treatment start up to 12 months later. About 120 adults in France who are starting acalabrutinib fo…
Matched conditions: CHRONIC LYMPHOCYTIC LEUKEMIA
Sponsor: AstraZeneca • Aim: Knowledge-focused
Last updated Jun 27, 2026 14:00 UTC
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Real-World check: how does acalabrutinib perform for CLL in belarus?
Knowledge-focused Recruiting nowThis study tracks 50 adults with chronic lymphocytic leukemia (CLL) who are starting acalabrutinib alone (no other cancer drugs) to see how long they stay on treatment and why they might stop. It collects real-world data on effectiveness and side effects, filling a knowledge gap …
Matched conditions: CHRONIC LYMPHOCYTIC LEUKEMIA
Sponsor: AstraZeneca • Aim: Knowledge-focused
Last updated Jun 27, 2026 14:00 UTC
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Leukemia drug study probes thinking and memory side effects
Knowledge-focused Recruiting nowThis study looks at whether targeted cancer drugs called TKIs affect brain health and well-being in people with chronic leukemia. Researchers will compare 400 patients who receive TKI therapy to those who do not. The goal is to understand if these treatments cause cognitive chang…
Matched conditions: CHRONIC LYMPHOCYTIC LEUKEMIA
Sponsor: University of Rochester NCORP Research Base • Aim: Knowledge-focused
Last updated Jun 27, 2026 13:06 UTC
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2000 volunteers help create a gold standard for cancer blood tests
Knowledge-focused Recruiting nowThis study collects blood and tissue samples from 2000 people—some with cancer and some without—to create a blinded reference set. Researchers will use these samples to evaluate how well new blood tests can detect many types of cancer early. The goal is to improve the accuracy of…
Matched conditions: CHRONIC LYMPHOCYTIC LEUKEMIA
Sponsor: Alliance for Clinical Trials in Oncology • Aim: Knowledge-focused
Last updated Jun 27, 2026 13:00 UTC
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Is early CLL treatment worth the cost? new study aims to find out
Knowledge-focused Recruiting nowThis study looks at the costs and quality of life for people with high-risk chronic lymphocytic leukemia (CLL) who either start treatment right away or wait. Researchers will track medical visits, tests, and hospital stays over 10 years. The goal is to see which approach gives th…
Matched conditions: CHRONIC LYMPHOCYTIC LEUKEMIA
Sponsor: Canadian Cancer Trials Group • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:30 UTC
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CLL study tracks Long-Term survival after First-Line treatment
Knowledge-focused Recruiting nowThis observational study follows 2,000 people with chronic lymphocytic leukemia (CLL) who have completed first-line treatment in earlier clinical trials. Researchers will collect data from routine care to see how different treatment sequences affect overall survival, quality of l…
Matched conditions: CHRONIC LYMPHOCYTIC LEUKEMIA
Sponsor: German CLL Study Group • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:26 UTC
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CLL study seeks 2,750 volunteers to unlock leukemia secrets
Knowledge-focused Recruiting nowThis study aims to collect tissue samples and medical information from up to 2,750 people with chronic lymphocytic leukemia (CLL) or related conditions. Researchers hope to learn more about what causes CLL and how it behaves. Participants will not receive any new treatment; the g…
Matched conditions: CHRONIC LYMPHOCYTIC LEUKEMIA
Sponsor: Dana-Farber Cancer Institute • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:23 UTC
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Scientists hunt for clues to CLL drug resistance in new study
Knowledge-focused Recruiting nowThis study aims to understand why some people with chronic lymphocytic leukemia (CLL) respond well to a new class of drugs called BTK degraders, while others do not. Researchers will collect blood, bone marrow, or lymph node samples from 60 patients over 9 years and follow them f…
Matched conditions: CHRONIC LYMPHOCYTIC LEUKEMIA
Sponsor: Nantes University Hospital • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:23 UTC
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Massive data hunt aims to unlock secrets of stem cell transplants
Knowledge-focused Recruiting nowThis study gathers basic health information from 2000 people receiving stem cell transplants for blood cancers or immune disorders. The goal is to track survival and complications to help doctors and researchers improve future treatments. Participants must be getting a standard t…
Matched conditions: CHRONIC LYMPHOCYTIC LEUKEMIA
Sponsor: Wake Forest University Health Sciences • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:06 UTC
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Mayo clinic launches study to uncover hidden bone marrow weakness in blood cancer patients
Knowledge-focused Recruiting nowThis study looks at how chronic lymphocytic leukemia (CLL) and its early stage, monoclonal B-cell lymphocytosis (MBL), affect the bone marrow's ability to fight infections. Researchers will compare bone marrow samples from 50 participants—including people with CLL, people with MB…
Matched conditions: CHRONIC LYMPHOCYTIC LEUKEMIA
Sponsor: Mayo Clinic • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:02 UTC
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CLL drug venetoclax under the microscope: genetic clues may improve treatment
Knowledge-focused Recruiting nowThis study tracks genetic changes in chronic lymphocytic leukemia (CLL) cells during treatment with the drug venetoclax. Researchers aim to understand how the cancer evolves as the drug is started. 75 adults with relapsed or refractory CLL will receive venetoclax and undergo regu…
Matched conditions: CHRONIC LYMPHOCYTIC LEUKEMIA
Phase: PHASE2 • Sponsor: National Heart, Lung, and Blood Institute (NHLBI) • Aim: Knowledge-focused
Last updated Jun 27, 2026 09:08 UTC
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Lymphoma Patients' vaccine response under microscope
Knowledge-focused Recruiting nowThis study looks at how the immune system of people with lymphoma responds to flu and COVID vaccines. Researchers will measure antibody levels and immune cells over time in 200 participants with different types of lymphoma. The goal is to understand how lymphoma and its treatment…
Matched conditions: CHRONIC LYMPHOCYTIC LEUKEMIA
Sponsor: Emory University • Aim: Knowledge-focused
Last updated Jun 27, 2026 09:05 UTC
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Blood cancer Patients' vaccine response under the microscope
Knowledge-focused Recruiting nowThis study looks at how well vaccines for flu, COVID-19, shingles, hepatitis B, and pneumonia work in people with certain blood cancers like chronic lymphocytic leukemia (CLL) and non-Hodgkin lymphomas. Researchers will measure immune responses through blood samples before and af…
Matched conditions: CHRONIC LYMPHOCYTIC LEUKEMIA
Phase: PHASE4 • Sponsor: National Heart, Lung, and Blood Institute (NHLBI) • Aim: Knowledge-focused
Last updated Jun 27, 2026 09:02 UTC
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New cancer drugs may harm hearts – study aims to find Who's at risk
Knowledge-focused Recruiting nowThis study follows 100 people taking newer BTK inhibitor drugs (acalabrutinib or zanubrutinib) for blood cancers like leukemia or lymphoma. Researchers want to see how often these drugs cause high blood pressure or heart rhythm problems, and find early warning signs. Participants…
Matched conditions: CHRONIC LYMPHOCYTIC LEUKEMIA
Sponsor: Centre Hospitalier Universitaire Dijon • Aim: Knowledge-focused
Last updated Jun 27, 2026 08:01 UTC
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Scientists track fuel sources of leukemia cells in patients
Knowledge-focused Recruiting nowThis study looks at how cancer cells in chronic lymphocytic leukemia (CLL) use nutrients like sugar and glutamine. Researchers will give participants special labeled nutrients and then measure how the cells process them. The goal is to understand cancer cell metabolism better, no…
Matched conditions: CHRONIC LYMPHOCYTIC LEUKEMIA
Sponsor: University of Wisconsin, Madison • Aim: Knowledge-focused
Last updated Jun 27, 2026 08:00 UTC
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CAR-T cell patients monitored for 15 years in new study
Knowledge-focused Recruiting nowThis study follows 500 people who received CAR-T cells in earlier trials for blood cancers like lymphoma and multiple myeloma. Researchers will check for new cancers and track long-term safety and effectiveness over 15 years. No new treatment is given; it is purely an observation…
Matched conditions: CHRONIC LYMPHOCYTIC LEUKEMIA
Sponsor: Medical College of Wisconsin • Aim: Knowledge-focused
Last updated Jun 27, 2026 07:56 UTC
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Real-World study tracks Zanubrutinib's impact on blood cancer patients
Knowledge-focused Recruiting nowThis study follows 705 adults with Waldenström's macroglobulinemia, chronic lymphocytic leukemia, marginal zone lymphoma, or follicular lymphoma who are taking zanubrutinib (with or without obinutuzumab). Researchers will track hospital visits, quality of life, and how well the d…
Matched conditions: CHRONIC LYMPHOCYTIC LEUKEMIA
Sponsor: iOMEDICO AG • Aim: Knowledge-focused
Last updated Jun 27, 2026 07:51 UTC
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Tiny heart monitor tracks dangerous rhythms in cancer patients
Knowledge-focused Recruiting nowThis study is for people starting a type of cancer drug called BTK inhibitors, which can sometimes cause irregular heartbeats. Researchers will implant a small heart monitor under the skin to watch for these heart rhythm problems continuously for up to 5 years. The goal is to lea…
Matched conditions: CHRONIC LYMPHOCYTIC LEUKEMIA
Phase: NA • Sponsor: Northwell Health • Aim: Knowledge-focused
Last updated Jun 26, 2026 18:46 UTC
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CAR-T therapy may erase vaccine immunity, new study warns
Knowledge-focused Recruiting nowThis study looks at whether CAR-T cell therapy reduces the body's ability to fight off diseases like measles and mumps that were previously prevented by vaccines. Researchers will measure antibody levels in 45 adults with multiple myeloma or non-Hodgkin lymphoma before and after …
Matched conditions: CHRONIC LYMPHOCYTIC LEUKEMIA
Sponsor: OHSU Knight Cancer Institute • Aim: Knowledge-focused
Last updated Jun 26, 2026 17:22 UTC