New drug aims to keep leukemia at bay after first treatment
NCT ID NCT07509151
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This Phase 3 trial is testing whether the drug surovatamig can help people with a specific type of chronic lymphocytic leukemia (CLL) or small lymphocytic lymphoma (SLL) stay in remission longer after their first round of treatment. About 420 participants will either receive surovatamig as a shot under the skin or be watched without extra treatment. The study focuses on patients whose cancer has a genetic marker called unmutated IGHV, which tends to be more aggressive.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
Surovatamig (also known as TNB-486, AZD0486) - a drug given as a shot under the skin
What this could lead to
If successful, this could provide a new option to keep CLL/SLL in check longer after initial treatment, potentially delaying relapse.
What could go wrong
This is an early-stage Phase 3 trial, so results are not yet known. The drug may cause side effects or not improve outcomes compared to observation alone.
Disclaimer
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This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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Research Site
NOT_YET_RECRUITINGAdelaide, 5000, Australia
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NOT_YET_RECRUITINGFitzroy, 3065, Australia
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Research Site
NOT_YET_RECRUITINGHeidelberg, 3084, Australia
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RECRUITINGNedlands, 6009, Australia
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NOT_YET_RECRUITINGPerth, 6847, Australia
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NOT_YET_RECRUITINGRockingham, 6168, Australia
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NOT_YET_RECRUITINGCalgary, Alberta, T2N 5G2, Canada
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NOT_YET_RECRUITINGVancouver, British Columbia, V5Z 4E6, Canada
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NOT_YET_RECRUITINGHalifax, Nova Scotia, B3H 2Y9, Canada
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NOT_YET_RECRUITINGHamilton, Ontario, L8V 5C2, Canada
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RECRUITINGToronto, Ontario, M5G 2L7, Canada
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NOT_YET_RECRUITINGMontreal, Quebec, H2L 4M1, Canada
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NOT_YET_RECRUITINGMontreal, Quebec, H3T 1E2, Canada
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NOT_YET_RECRUITINGQuébec, Quebec, G1J 1Z4, Canada
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Research Site
NOT_YET_RECRUITINGAdapazarı, 54100, Turkey (Türkiye)
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RECRUITINGAntalya, 07025, Turkey (Türkiye)
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NOT_YET_RECRUITINGIstanbul, 34098, Turkey (Türkiye)
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NOT_YET_RECRUITINGIstanbul, 34517, Turkey (Türkiye)
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NOT_YET_RECRUITINGIstanbul, 34899, Turkey (Türkiye)
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RECRUITINGKocaeli, 41380, Turkey (Türkiye)
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RECRUITINGMezitli, 33200, Turkey (Türkiye)
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NOT_YET_RECRUITINGEdinburgh, EH4 2XU, United Kingdom
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Research Site
NOT_YET_RECRUITINGHampshire, SO16 6YD, United Kingdom
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NOT_YET_RECRUITINGLeeds, LS9 7TF, United Kingdom
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NOT_YET_RECRUITINGLondon, NW1 2BU, United Kingdom
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NOT_YET_RECRUITINGLondon, SE5 9RS, United Kingdom
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RECRUITINGManchester, M20 4BX, United Kingdom
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NOT_YET_RECRUITINGNottingham, NG5 1PB, United Kingdom
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NOT_YET_RECRUITINGOxford, OX3 7LE, United Kingdom
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Research Site
NOT_YET_RECRUITINGSutton, SM2 5PT, United Kingdom