Off-the-Shelf CAR t cells take on tough lymphomas and leukemias
NCT ID NCT03666000
First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This early-phase trial is testing a new type of CAR T cell therapy called Azer-cel, which is made from healthy donor cells rather than the patient's own cells. It aims to treat adults with relapsed or refractory non-Hodgkin lymphoma, B-cell acute lymphoblastic leukemia, and related blood cancers. Participants receive the donor CAR T cells along with chemotherapy and IL-2 to see if the treatment is safe and can shrink tumors.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
Azer-cel (azercabtagene zapreleucel), a donor-derived CAR T cell therapy targeting CD19, given with chemotherapy (fludarabine, cyclophosphamide) and IL-2
What this could lead to
If it works, this could provide a readily available, off-the-shelf cell therapy option for patients with hard-to-treat blood cancers who have run out of other treatments.
What could go wrong
This is an early (Phase 1) trial with a small number of participants, so safety and effectiveness are not yet proven. CAR T therapies can cause serious side effects like cytokine release syndrome and neurological problems.
Disclaimer
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This is a summary of
the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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Banner MD Anderson Cancer Center
COMPLETEDGilbert, Arizona, 85234, United States
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Barbara Ann Karmanos Cancer Institute (Wayne State University)
COMPLETEDDetroit, Michigan, 48201, United States
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Barwon Health - Andrew Love Cancer Centre
RECRUITINGGeelong, Victoria, 3320, Australia
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Baylor University Medical Center
RECRUITINGDallas, Texas, 75246, United States
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City of Hope
COMPLETEDDuarte, California, 91010, United States
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Columbia University Irving Medical Center/New York Presbyterian Hospital
RECRUITINGNew York, New York, 10032, United States
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Dana-Farber Cancer Institute
COMPLETEDBoston, Massachusetts, 02215, United States
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Duke University
COMPLETEDDurham, North Carolina, 27708, United States
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H. Lee Moffitt Cancer Center
RECRUITINGTampa, Florida, 33612, United States
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Lifespan Cancer Institute at Rhode Island Hospital
RECRUITINGProvidence, Rhode Island, 02903, United States
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Liverpool Hospital
RECRUITINGLiverpool, New South Wales, 2170, Australia
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MD Anderson
COMPLETEDHouston, Texas, 77030, United States
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Medical College of Wisconsin
RECRUITINGMilwaukee, Wisconsin, 53226, United States
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Northside Hospital Cancer Institute
RECRUITINGAtlanta, Georgia, 30342, United States
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Ohio State University
COMPLETEDColumbus, Ohio, 43210, United States
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Royal Adelaide Hospital
RECRUITINGAdelaide, South Australia, 5000, Australia
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Royal Prince Alfred Hospital
RECRUITINGCamperdown, New South Wales, 2050, Australia
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St Vincent's Hospital Melbourne
RECRUITINGFitzroy, Victoria, 3065, Australia
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Tufts Medical Center
RECRUITINGBoston, Massachusetts, 02111, United States
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University of Maryland
RECRUITINGBaltimore, Maryland, 21201, United States
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University of Minnesota
RECRUITINGMinneapolis, Minnesota, 55455, United States
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Weill Cornell Medical College - NY Presbyterian Hospital
COMPLETEDNew York, New York, 10021, United States
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Winship Cancer Institute Emory University
RECRUITINGAtlanta, Georgia, 30322, United States
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Contact