Custom-Made vaccine takes on untreated leukemia in early trial
NCT ID NCT03219450
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This early-phase study tests a personalized neoantigen vaccine (NeoVax) in 15 people with untreated chronic lymphocytic leukemia (CLL) who have a specific genetic marker (IGHV unmutated). The vaccine is designed to train the immune system to attack each person's unique cancer cells. Some participants also receive low-dose cyclophosphamide or pembrolizumab to boost the immune response. The main goals are to see if the vaccine can be made in time and if it is safe.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
Personalized neoantigen vaccine (NeoVax) with or without low-dose cyclophosphamide or pembrolizumab
What this could lead to
If successful, this could point toward a new way to control CLL without immediate chemotherapy, using the body's own immune system.
What could go wrong
This is a very early, small Phase 1 trial with only 15 people. The main goal is safety and feasibility, not yet effectiveness. The vaccine is personalized, which is complex and may not work for everyone.
Disclaimer
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the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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Dana-Farber Cancer Institute
RECRUITINGBoston, Massachusetts, 02215, United States
Contact
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