Suicide-Gene t cells aim to stop blood cancer relapse

This early-phase trial tests whether infusing specially designed immune cells can prevent blood cancer from coming back after a stem cell transplant. The cells target a specific protein (HLA-DPB1*04:01) found on many cancer cells and include a 'suicide switch' to turn them off if needed. Six adults with certain blood cancers who have already received a transplant from a donor without that protein will receive increasing doses of these cells. The main goal is to find a safe dose that does not cause severe graft-versus-host disease.