New hope in blood cancer battle: Next-Gen drug tested against standard therapy

NCT ID NCT05254743

Recruiting now Disease control Sponsor: Loxo Oncology, Inc. Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jul 17, 2026 · Updated 1 time

Summary

This study tests whether a newer drug called pirtobrutinib works better than the current standard drug ibrutinib for people with chronic lymphocytic leukemia or small lymphocytic lymphoma. About 737 adults who need treatment for their cancer will be randomly assigned to receive one of the two drugs. The goal is to see which drug shrinks tumors more effectively and keeps the cancer from growing longer.

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Conditions

The condition(s) this trial relates to.

B-cell chronic lymphocytic leukemia B-cell neoplasm hematologic disorder Leukemia, B-Cell lymphoid leukemia non-Hodgkin lymphoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

CHRONIC LYMPHOCYTIC LEUKEMIA LEUKEMIA, B-CELL LEUKEMIA, LYMPHOCYTIC SMALL LYMPHOCYTIC LYMPHOMA

Contacts and locations

Locations

9 Eylul University Hospital
ACTIVE_NOT_RECRUITING

Balçova, 35100, Turkey (Türkiye)
AIDPORT Sp. z o.o.
RECRUITING

Skórzewo, 60-185, Poland
Acıbadem Maslak Hastanesi
COMPLETED

Istanbul, 34457, Turkey (Türkiye)
Affiliated Cancer Hospital of Xinjiang Medical University
ACTIVE_NOT_RECRUITING

Ürümqi, 830000, China
Alexander Fleming
RECRUITING

Ciudad Autónoma de Buenos Aire, C1426ANZ, Argentina
American Hospital
ACTIVE_NOT_RECRUITING

Istanbul, 34365, Turkey (Türkiye)
American Oncology Partners of Maryland, PA
RECRUITING

Bethesda, Maryland, 20817, United States
Anhui Provincial Hospital
RECRUITING

Hefei, 230001, China
Ankara University Medicine Hospital
RECRUITING

Mamak, 06590, Turkey (Türkiye)
Azienda Ospedaliera Nazionale Santi Antonio e Biagio e Cesare Arrigo
RECRUITING

Alessandria, 15100, Italy
Azienda Unita Sanitaria Locale di Reggio Emilia
ACTIVE_NOT_RECRUITING

Reggio Emilia, 42122, Italy
Blood Institute of the Chinese Academy of Medical science
ACTIVE_NOT_RECRUITING

Tianjin, 300020, China
Bristol Haematology and Oncology Centre
RECRUITING

Bristol, BS2 8ED, United Kingdom
CEPHO - Centro de Estudos e Pesquisas de Hematologia e Oncologia
RECRUITING

Santo André, 09060-650, Brazil
CHD Vendee
RECRUITING

La Roche-sur-Yon, 85000, France
CHRU De Tours
RECRUITING

Tours, 37044, France
CHU de Nantes - Hotel Dieu
RECRUITING

Nantes, 44093, France
California Cancer Associates for Research and Excellence
ACTIVE_NOT_RECRUITING

San Marcos, California, 92069, United States
Cancer Care Associates of York
ACTIVE_NOT_RECRUITING

York, Pennsylvania, 17403, United States
Cancer Care Manitoba
ACTIVE_NOT_RECRUITING

Winnipeg, R3E 0V9, Canada
Cancer Specialists of North Florida -St Augustine
RECRUITING

Saint Augustine, Florida, 32086, United States
CeCim Biocinetic
ACTIVE_NOT_RECRUITING

Santiago, 8320000, Chile
Centre Antoine Lacassagne
RECRUITING

Nice, 06189, France
Centre Hospitalier Lyon Sud
RECRUITING

Pierre-Bénite, 69495, France
Centre Hospitalier Universitaire (Limoges) (CHU DUPUYTREN 1)
RECRUITING

Limoges, 87042, France
Centre Hospitalier du Mans
RECRUITING

Le Mans, 72000, France
Centre de Lutte Contre le Cancer - Centre Henri Becquerel Normandie Rouen
RECRUITING

Rouen, 76038, France
Centro Gaucho Integrado - Mae de Deus Center
RECRUITING

Porto Alegre, 90110270, Brazil
Centro Integrado de Oncologia de Curitiba
ACTIVE_NOT_RECRUITING

Curitiba, 80810050, Brazil
Centro Integrado de Pesquisa Clinica
RECRUITING

São José do Rio Preto, 15090-000, Brazil
Centro de Investigaciones Clínicas Viña del Mar (CIC)
ACTIVE_NOT_RECRUITING

Viña del Mar, 2520000, Chile
Chang Bing Show Chwan Memorial Hospital
RECRUITING

Changhua, 710, Taiwan
Chang Gung Memorial Hospital - Chiayi
RECRUITING

Chiayi County, 61363, Taiwan
Clinica Universitaria De Navarra
RECRUITING

Pamplona, 31008, Spain
Clínica de Nefrología, Urología y Enfermedades Cardiovasculares
RECRUITING

Santa Fe, 3000, Argentina
Debreceni Egyetem Orvos-es Egészsegtudomanyi Centrum
RECRUITING

Debrecen, 4004, Hungary
Dunedin Hospital
ACTIVE_NOT_RECRUITING

Dunedin, 9016, New Zealand
Ege Üniversitesi
ACTIVE_NOT_RECRUITING

Bornova, 35040, Turkey (Türkiye)
Fakultni Nemocnice Ostrava
RECRUITING

Ostrava, 708 52, Czechia
Fakultni Nemocnice Plzen
RECRUITING

Pilsen, 305 99, Czechia
Fakultni nemocnice Brno
RECRUITING

Brno, 62500, Czechia
Fakultni nemocnice Hradec Kralove
RECRUITING

Hradec Králové, 500 05, Czechia
Fakultni nemocnice Kralovske Vinohrady
RECRUITING

Prague, 10034, Czechia
First Affiliated Hosp of College of Med, Zhejiang University
RECRUITING

Hangzhou, 310003, China
Florida Cancer Specialists
RECRUITING

Fort Myers, Florida, 33916-2233, United States
Florida Cancer Specialists East
RECRUITING

West Palm Beach, Florida, 33401, United States
Fudan University Shanghai Cancer Center
RECRUITING

Shanghai, 200032, China
Fundação Pio XII - Hospital de Câncer de Barretos
RECRUITING

Barretos, 14784400, Brazil
Gazi University Faculty of Medicine
ACTIVE_NOT_RECRUITING

Ankara, 6500, Turkey (Türkiye)
Gemeinschaftspraxis für Hämatologie und Onkologie (Gefos)
ACTIVE_NOT_RECRUITING

Dortmund, 44309, Germany
Guangxi Medical University Affiliated Tumor Hospital
RECRUITING

Nanning, 530021, China
HOPE Centre
ACTIVE_NOT_RECRUITING

Leicester, LE1 5WW, United Kingdom
Hadassah Medical Center
RECRUITING

Jerusalem, 9112001, Israel
Hainan General Hospital
ACTIVE_NOT_RECRUITING

Haikou, 570311, China
Hanusch Krankenhaus
ACTIVE_NOT_RECRUITING

Vienna, 1140, Austria
Hematology Oncology Clinic
ACTIVE_NOT_RECRUITING

Baton Rouge, Louisiana, 70809, United States
Hemocentro Unicamp
RECRUITING

Campinas, 13083-878, Brazil
Hopital de L'Enfant Jesus
RECRUITING

Québec, G1J 1Z4, Canada
Hopital de la Pitie Salpetriere
RECRUITING

Paris, 75651, France
Hospital BP
RECRUITING

São Paulo, 01321-001, Brazil
Hospital Clinic de Barcelona
ACTIVE_NOT_RECRUITING

Barcelona, 08036, Spain
Hospital Costa Del Sol
RECRUITING

Marbella, 29600, Spain
Hospital De Navarra
RECRUITING

Pamplona, 31008, Spain
Hospital Duran i Reynals
ACTIVE_NOT_RECRUITING

L'Hospitalet de Llobregat, 08908, Spain
Hospital Erasto Gaertner - Liga Paranaense de Combate ao Câncer
RECRUITING

Curitiba, 81520060, Brazil
Hospital Privado De Comunidad
ACTIVE_NOT_RECRUITING

Mar del Plata, 7600, Argentina
Hospital Santa Marcelina
RECRUITING

São Paulo, 08270-120, Brazil
Hospital Universitari Vall d'Hebron
RECRUITING

Barcelona, 8035, Spain
Hospital Universitario Infanta Leonor-INTERNAL MED
RECRUITING

Madrid, 28031, Spain
Hospital Universitario Marqués de Valdecilla
RECRUITING

Santander, 39008, Spain
Hospital Universitario Puerta de Hierro Majadahonda
RECRUITING

Majadahonda, 28222, Spain
Hospital Universitario Ramón y Cajal
RECRUITING

Madrid, 28034, Spain
Hospital Universitario Virgen Del Rocio
RECRUITING

Seville, 41013, Spain
Hospital Universitario Virgen Macarena
RECRUITING

Seville, 41009, Spain
Hospital Uopeccan - Centro de Pesquisa Clinica
RECRUITING

Cascavel, 85806-300, Brazil
Hospital da Clinicas da Faculdade de Medicina da USP
RECRUITING

São Paulo, 05403-000, Brazil
Hospital de Clínicas de Ribeirão Preto
RECRUITING

Ribeirão Preto, 14051-140, Brazil
Hospital de la Santa Creu i Sant Pau
RECRUITING

Barcelona, 08025, Spain
Hunan Cancer Hospital
ACTIVE_NOT_RECRUITING

Changsha, 410013, China
Hôpital de Pontchaillou
RECRUITING

Rennes, 35033, France
IRCCS Ospedale San Raffaele
RECRUITING

Milan, 20132, Italy
Inje Univ Busan Paik Hospital
RECRUITING

Busan, 47392, South Korea
Inmunocel
ACTIVE_NOT_RECRUITING

Santiago, 7580206, Chile
Instituto do Câncer - Hospital São Vicente de Paulo
RECRUITING

Passo Fundo, 99010090, Brazil
Istanbul University Istanbul Medicine Faculty
RECRUITING

Faith, 34732, Turkey (Türkiye)
Istituto Europeo di Oncologia
RECRUITING

Milan, 20141, Italy
Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori
RECRUITING

Meldola, 47014, Italy
Jiangxi Provincial Cancer Hospital
ACTIVE_NOT_RECRUITING

Nanchang, 330029, China
KO-MED Centra Kliniczne
ACTIVE_NOT_RECRUITING

Biała Podlaska, 21500, Poland
Kelsey Research Foundation
ACTIVE_NOT_RECRUITING

Houston, Texas, 77025, United States
Klinika Hematoonkologii i Transplantacji Szpiku,Samodzielny Publiczny Szpital Kliniczny Nr 1
ACTIVE_NOT_RECRUITING

Lublin, 20-081, Poland
Koo Foundation Sun Yan-Sen Cancer Center
RECRUITING

Taipei, 112, Taiwan
Kumamoto University Hospital
ACTIVE_NOT_RECRUITING

Kumamoto, 860-8556, Japan
Lumi Research
RECRUITING

Kingwood, Texas, 77339, United States
Markusovszky Egyetemi Oktatokorhaz
ACTIVE_NOT_RECRUITING

Szombathely, 9700, Hungary
Medical Oncology Associates, PS
RECRUITING

Spokane, Washington, 99208, United States
Middlemore Clinical Trials
RECRUITING

Papatoetoe, 2025, New Zealand
Momentum Clinical Research
RECRUITING

Newtown, 6242, New Zealand
MultiCare Health System Institute for Research and Innovation
ACTIVE_NOT_RECRUITING

Spokane, Washington, 99218, United States
National Cheng-Kung Uni. Hosp.
ACTIVE_NOT_RECRUITING

Tainan, 704, Taiwan
One Clinical Research
ACTIVE_NOT_RECRUITING

Nedlands, 6009, Australia
Onkologische Gemeinschaftspraxis / BAG
RECRUITING

Dresden, 01307, Germany
Pacific Cancer Medical Center, Inc
RECRUITING

Anaheim, California, 92801, United States
Policlinico Sant'Orsola Malpighi
ACTIVE_NOT_RECRUITING

Bologna, 40138, Italy
Pratia MCM Krakow
RECRUITING

Krakow, 30-510, Poland
Pratia Onkologia Katowice
RECRUITING

Katowice, 40519, Poland
Prisma Health Cancer Institute
ACTIVE_NOT_RECRUITING

Greenville, South Carolina, 29605, United States
Royal Victoria Hospital-Montreal
TERMINATED

Montreal, H3A 1A1, Canada
Samsung Medical Center
ACTIVE_NOT_RECRUITING

Seoul, 06351, South Korea
Sarah Cannon Research Institute SCRI
RECRUITING

Nashville, Tennessee, 37203, United States
Seoul National University Hospital
RECRUITING

Seoul, 03080, South Korea
Singleton Hospital
RECRUITING

Swansea, SA2 8QA, United Kingdom
Sociedad de Investigaciones Médicas Limitada
RECRUITING

Temuco, 4780000, Chile
Southern Medical University Nanfang Hospital
RECRUITING

Guangzhou, 510515, China
St Bartholomew's Hospital
ACTIVE_NOT_RECRUITING

London, EC1A 7BE, United Kingdom
St. Vincent Frontier Cancer Center
RECRUITING

Billings, Montana, 59102, United States
Stanford School of Medicine-Cancer Clinical Trials Office
RECRUITING

Palo Alto, California, 94305, United States
Sun Yat-sen University Cancer Center
RECRUITING

Guangzhou, 510060, China
Szpital Uniwersytecki nr 1 im. Antoniego Jurasza
RECRUITING

Bydgoszcz, 85-168, Poland
TOI Clinical Research
RECRUITING

Cerritos, California, 90703, United States
Tel Aviv Sourasky Medical Center
ACTIVE_NOT_RECRUITING

Tel Aviv, 6423906, Israel
The Catholic University of Korea-Seoul St. Mary's Hospital
RECRUITING

Seocho-Gu, 06591, South Korea
The Fourth Affiliated Hospital Zhejiang University School of Medicine
ACTIVE_NOT_RECRUITING

Yiwu, 322000, China
The Perth Blood Institute
RECRUITING

West Perth, 6005, Australia
The Second Affiliated Hospital of Zhejiang University School of Medicine
ACTIVE_NOT_RECRUITING

Hangzhou, 310009, China
The Second Hospital of Anhui Medical University
RECRUITING

Hefei, 231200, China
The Second Xiangya Hospital of Central South University
ACTIVE_NOT_RECRUITING

Changsha, 410011, China
Tianjin Medical University General Hospital
ACTIVE_NOT_RECRUITING

Tianjin, 300052, China
Tulane Cancer Center Office of Clinical Research
ACTIVE_NOT_RECRUITING

New Orleans, Louisiana, 70112, United States
Union Hospital Tongji Medical College Huazhong University of Science and Technology
ACTIVE_NOT_RECRUITING

Wuhan, 430022, China
Universitaetsklinikum Carl Gustav Carus an der TU Dresden, Medizinische Klinik und Poliklinik 1
ACTIVE_NOT_RECRUITING

Dresden, 01307, Germany
Universitaire Ziekenhuizen Leuven - Campus Gasthuisberg
RECRUITING

Leuven, 3000, Belgium
Universitätsklinikum Ulm
ACTIVE_NOT_RECRUITING

Ulm, 89075, Germany
Uniwersytecki Szpital Kliniczny Klinika
RECRUITING

Wroclaw, 50-367, Poland
Uniwersyteckie Centrum Kliniczne
RECRUITING

Gdansk, 80-952, Poland
Upeclin - Unidade de Pesquisa Clínica da Faculdade de Medicina de Botucatu - UNESP
RECRUITING

Botucatu, 18618-687, Brazil
VITAZ
RECRUITING

Sint-Niklaas, B-9100, Belgium
Virginia Cancer Institute
RECRUITING

Richmond, Virginia, 23230, United States
Vseobecna fakultni nemocnice v Praze
RECRUITING

Prague, 12808, Czechia
Waikato Hospital
ACTIVE_NOT_RECRUITING

Hamilton, 3204, New Zealand
Western Health, Sunshine Hospital
ACTIVE_NOT_RECRUITING

St Albans, 3021, Australia
Wu Han Tongji Hospital
ACTIVE_NOT_RECRUITING

Wuhan, 430030, China
Yamagata University Hospital
RECRUITING

Yamagata, 990-9585, Japan

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