Cure My Disease

Don't miss your cure!

 Log in / Sign up

New pill shows promise for Hard-to-Treat blood cancers

NCT ID NCT05602363

Recruiting now Disease control Sponsor: Carna Biosciences, Inc. Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This early-stage trial tests an oral drug called AS-1763 in about 120 adults with chronic lymphocytic leukemia, small lymphocytic lymphoma, or other B-cell non-Hodgkin lymphomas who have already tried at least two other treatments. The study aims to find the safest dose and check if the drug can shrink tumors or control the disease. Participants take the pill twice daily, and researchers monitor side effects and how the drug moves through the body.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance
AS-1763 (docirbrutinib) oral tablet
What this could lead to
If this trial succeeds, it could point toward a new treatment option for people with certain blood cancers who have run out of effective therapies.
What could go wrong
This is an early Phase 1b study with only 120 participants, so the drug may not prove safe or effective enough for wider use. Side effects and limited benefit are possible.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Get updates

Get notified about this study

Sign up to get updates when this study changes or when new studies for B-CELL MALIGNANCY are added.

Our safety recommendation!

By submitting, you agree to our Terms of use

Conditions

The condition(s) this trial relates to.

B-cell chronic lymphocytic leukemia B-cell neoplasm follicular lymphoma Lymphoma, B-Cell, Marginal Zone mantle cell lymphoma marginal zone lymphoma non-Hodgkin lymphoma Waldenstrom macroglobulinemia

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

B-CELL MALIGNANCY CHRONIC LYMPHOCYTIC LEUKEMIA FOLLICULAR LYMPHOMA MANTLE CELL LYMPHOMA MARGINAL ZONE LYMPHOMA NON-HODGKIN LYMPHOMA SMALL LYMPHOCYTIC LYMPHOMA WALDENSTROM MACROGLOBULINEMIA

Contacts and locations

Study contacts

  • Contact

    Phone: •••-•••-•••• Email: •••••@•••••

Locations

  • American Oncology Partners

    RECRUITING

    Fort Wayne, Indiana, 46804, United States

    Contact Phone: •••-•••-•••• Email: •••••@•••••

    Contact

  • Duke University

    RECRUITING

    Durham, North Carolina, 27705, United States

    Contact

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • Moffitt Cancer Center

    RECRUITING

    Tampa, Florida, 33612, United States

    Contact

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • Mount Sinai Comprehensive Cancer Center

    RECRUITING

    Miami Beach, Florida, 33140, United States

    Contact

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • Northwestern Memorial Hospital

    RECRUITING

    Chicago, Illinois, 60661, United States

    Contact

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • Oncology Consultants

    RECRUITING

    Houston, Texas, 77030, United States

    Contact

    Contact Phone: •••-•••-•••• Email: •••••@•••••

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • Optum Medical Care PC

    RECRUITING

    Westbury, New York, 11590, United States

    Contact Phone: •••-•••-•••• Email: •••••@•••••

    Contact

  • Taylor Cancer Research Center

    RECRUITING

    Maumee, Ohio, 43537, United States

    Contact

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • The Medical College of Wisconsin

    RECRUITING

    Milwaukee, Wisconsin, 53266, United States

    Contact Phone: •••-•••-•••• Email: •••••@•••••

    Contact

  • UC Irvine Health

    RECRUITING

    Orange, California, 92868, United States

    Contact Phone: •••-•••-•••• Email: •••••@•••••

    Contact

  • University of Maryland Medical Center - Greenebaum Comprehensive Cancer Center

    RECRUITING

    Baltimore, Maryland, 21201, United States

    Contact Phone: •••-•••-•••• Email: •••••@•••••

    Contact

  • University of Massachusetts Memorial Medical Center

    RECRUITING

    Worcester, Massachusetts, 01655, United States

    Contact

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • University of Texas MD Anderson Cancer Center

    RECRUITING

    Houston, Texas, 77030, United States

    Contact Phone: •••-•••-•••• Email: •••••@•••••

    Contact

More trials for these conditions

Other studies related to the condition(s) this trial covers.