New hope for Tough-to-Treat blood cancers: pirtobrutinib trial launches

NCT ID NCT06588478

Recruiting now Disease control Sponsor: Loxo Oncology, Inc. Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests three different doses of a drug called pirtobrutinib in people with chronic lymphocytic leukemia (CLL) or small lymphocytic lymphoma (SLL) whose cancer came back or didn't respond after treatment with a BTK inhibitor. About 249 participants will take part. The goal is to see which dose works best and is safest. The study also includes a separate group of people who have never been treated for CLL/SLL and have a specific genetic change (17p deletion).

This is an AI summary of the original study and may miss details. Read our disclaimer.

Get updates

Get notified about this study

Our safety recommendation!

By submitting, you agree to our Terms of use

Conditions

The condition(s) this trial relates to.

B-cell chronic lymphocytic leukemia

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

CHRONIC LYMPHOCYTIC LEUKEMIA SMALL LYMPHOCYTIC LYMPHOMA

Contacts and locations

Locations

A.O.U.C. Policlinico di Bari
RECRUITING

Bari, 70124, Italy
AIDPORT Sp. z o.o.
RECRUITING

Skórzewo, 60-185, Poland
AO Santa Maria della Misericordia
RECRUITING

Perugia, 06132, Italy
AOU Policlinico Umberto I
RECRUITING

Roma, 00161, Italy
ASST Grande Ospedale Metropolitano Niguarda
RECRUITING

Milan, 20162, Italy
AZ Delta vzw
RECRUITING

Roeselare, 8800, Belgium
AZ Nikolaas
RECRUITING

Sint-Niklaas, B-9100, Belgium
AZ Sint-Jan Brugge-Oostende AV
RECRUITING

Bruges, 8000, Belgium
Aarhus Universitetshospital, Skejby
RECRUITING

Aarhus, 8200, Denmark
American Oncology Partners, PA
RECRUITING

Bethesda, Maryland, 20817, United States
Ankara University Health Practice and Research Hospitals
RECRUITING

Ankara, 06620, Turkey (Türkiye)
Attikon General University Hospital
RECRUITING

Chaïdári, 12462, Greece
Az. Osp. Ospedali Riuniti VILLA SOFIA-CERVELLO
RECRUITING

Palermo, 90146, Italy
Azienda Ospedale - Università Padova
RECRUITING

Padova, 35128, Italy
Azienda Ospedaliera Universitaria Careggi
RECRUITING

Florence, 50134, Italy
Azienda Ospedaliero Universitaria Maggiore della Carità
RECRUITING

Novara, 28100, Italy
Azienda Ospedaliero Universitaria S.Anna
RECRUITING

Cona, 44124, Italy
Bankstown-Lidcombe Hospital
RECRUITING

Bankstown, 2200, Australia
Boston Medical Center
RECRUITING

Boston, Massachusetts, 02118, United States
Box Hill Hospital
RECRUITING

Box Hill, 3128, Australia
CHR Verviers - La Tourelle
RECRUITING

Verviers, 4800, Belgium
Calvary Mater Newcastle
RECRUITING

Waratah, 2298, Australia
Cancer Care Associates Of York
RECRUITING

York, Pennsylvania, 17403, United States
Centre Antoine-Lacassagne
RECRUITING

Nice, 06189, France
Centre Hospitalier Régional Universitaire de Tours - Hôpital Bretonneau
RECRUITING

Tours, 37044 Cedex 9, France
Centre Hospitalier Universitaire de Caen - Hôpital Côte de Nacre
RECRUITING

Caen, 14033, France
Centre Hospitalier d'Argenteuil Victor Dupouy
RECRUITING

Argenteuil, 95107, France
Centre Hospitalier du Mans
RECRUITING

Le Mans, 72000, France
Centrum für Hämatologie und Onkologie Bethanien
RECRUITING

Frankfurt, 60389, Germany
Chonnam National University Hwasun Hospital
RECRUITING

Hwasun-gun, 58128, South Korea
City of Hope National Medical Center
RECRUITING

Duarte, California, 91010, United States
City of Hope National Medical Center
RECRUITING

Irvine, California, 92618, United States
City of Hope National Medical Center, Atlanta Cancer Center
RECRUITING

Newnan, Georgia, 30265, United States
Clatterbridge Cancer Centre - Liverpool
RECRUITING

Liverpool, L7 8YA, United Kingdom
Clinica Universidad de Navarra
RECRUITING

Madrid, 28027, Spain
Clinique Saint Pierre
RECRUITING

Ottignies, 1340, Belgium
Coffs Harbour Health Campus
RECRUITING

Coffs Harbour, 2450, Australia
Comprehensive Cancer Centers of Nevada
RECRUITING

Henderson, Nevada, 89074, United States
Dr. Abdurrahman Yurtaslan Ankara Onkoloji Egitim ve Arastırma Hastanesi
RECRUITING

Ankara, 06200, Turkey (Türkiye)
Dél-Pesti Centrumkórház
RECRUITING

Budapest, 1097, Hungary
East Carolina University
RECRUITING

Greenville, North Carolina, 27834, United States
Ege Universitesi Hastanesi
RECRUITING

Izmir, 35100, Turkey (Türkiye)
Evangelismos General Hospital of Athens
RECRUITING

Athens, 106 76, Greece
Fakultna nemocnica s poliklinikou F.D.Roosevelta Banska Bystrica
RECRUITING

Banská Bystrica, 975 17, Slovakia
Fakultni nemocnice Hradec Kralove
RECRUITING

Hradec Králové, 500 05, Czechia
Fakultni nemocnice Kralovske Vinohrady
RECRUITING

Prague, 100 34, Czechia
Fakultní nemocnice Brno Bohunice
RECRUITING

Brno, 625 00, Czechia
Flinders Medical Centre
RECRUITING

Adelaide, 5042, Australia
Fondazione Policlinico Universitario Agostino Gemelli IRCCS - Università Cattolica del Sacro Cuore
RECRUITING

Roma, 00168, Italy
Fundeni Clinical Institute
RECRUITING

Bucharest, 022328, Romania
G. Papanikolaou General Hospital
RECRUITING

Thessaloniki, 570 10, Greece
General Hospital of Athens "Laiko"
RECRUITING

Αthens, 11526, Greece
Groupe Hospitalier de la Région de Mulhouse et Sud Alsace - Hôpital Emile Muller
RECRUITING

Mulhouse, 68100, France
Groupe Jolimont
RECRUITING

La Louvière, 7100, Belgium
Gulfport Memorial Hospital
RECRUITING

Gulfport, Mississippi, 39501, United States
Hammersmith Hospital
RECRUITING

London, W12 0HS, United Kingdom
Heartlands Hospital
RECRUITING

Birmingham, B9 5SS, United Kingdom
Hospital Clínic de Barcelona
RECRUITING

Barcelona, 08036, Spain
Hospital Costa del Sol
RECRUITING

Marbella, 29603, Spain
Hospital Universitari Vall d'Hebron
RECRUITING

Barcelona, 08035, Spain
Hospital Universitario Central de Asturias
RECRUITING

Oviedo, 33011, Spain
Hospital Universitario Infanta Leonor
RECRUITING

Madrid, 28031, Spain
Hospital Universitario Marqués de Valdecilla
RECRUITING

Santander, 39008, Spain
Hospital Universitario Puerta de Hierro Majadahonda
RECRUITING

Majadahonda, 28222, Spain
Hospital Universitario Ramón y Cajal
RECRUITING

Madrid, 28034, Spain
Hospital Universitario Virgen Del Rocio
RECRUITING

Seville, 41013, Spain
Hospital Universitario Virgen Macarena
RECRUITING

Seville, 41009, Spain
Hospital Universitario de Salamanca - Complejo Asistencial Universitario de Salamanca
RECRUITING

Salamanca, 37007, Spain
ICON Cancer Centre - Kurralta Park
RECRUITING

Kurralta Park, 5037, Australia
IN VIVO
RECRUITING

Bydgoszcz, 85-048, Poland
InVO Institut für Versorgungsforschung in der Onkologie
RECRUITING

Koblenz, 56068, Germany
Institut Català d'Oncologia - L'Hospitalet
RECRUITING

L'Hospitalet Del Llobregat, 08908, Spain
Institut Jules Bordet
RECRUITING

Anderlecht, 1070, Belgium
Institutul Oncologic Cluj
RECRUITING

Cluj-Napoca, 400015, Romania
Institutul Regional de Oncologie
RECRUITING

Iași, 700483, Romania
Ironwood Cancer & Research Centers
RECRUITING

Chandler, Arizona, 85224, United States
Klinikum Aschaffenburg-Alzenau
RECRUITING

Hösbach, 63768, Germany
Kocaeli Üniversitesi
RECRUITING

İzmit, 41380, Turkey (Türkiye)
Latrobe Regional Health
RECRUITING

Traralgon, 3844, Australia
Lincoln County Hospital
RECRUITING

Lincoln, LN2 5QY, United Kingdom
MD Anderson Cancer Center
RECRUITING

Madrid, 28033, Spain
MV-Zentrum für Onkologie und Hämatologie
RECRUITING

Cologne, 50677, Germany
Maidstone Hospital
RECRUITING

Maidstone, ME16 9QQ, United Kingdom
Memorial Antalya Hospital
RECRUITING

Antalya, 07090, Turkey (Türkiye)
Mission Cancer + Blood
RECRUITING

Waukee, Iowa, 50263, United States
Narodny onkologicky ustav
RECRUITING

Bratislava, 833 10, Slovakia
Northwick Park Hospital
RECRUITING

Harrow, HA1 3UJ, United Kingdom
OSP Göttingen
RECRUITING

Göttingen, 37073, Germany
Odense Universitetshospital
RECRUITING

Odense, 5000, Denmark
Ondokuz Mayıs Universitesi
RECRUITING

Samsun, 55139, Turkey (Türkiye)
Onkologisches Ambulanzzentrum Hannover
RECRUITING

Hanover, 30171, Germany
Ovidius Clinical Hospital OCH
RECRUITING

Ovidiu, 905900, Romania
Palo Alto Medical Foundation Research Institute (PAMFRI)
RECRUITING

Palo Alto, California, 94304, United States
Pratia MCM Krakow
RECRUITING

Krakow, 30-727, Poland
Pratia Onkologia Katowice
RECRUITING

Katowice, 40-519, Poland
Princess Alexandra Hospital
RECRUITING

Woolloongabba, 4102, Australia
Pusan National University Hospital
RECRUITING

Busan, 49241, South Korea
Pécsi Tudományegyetem Klinikai Központ
RECRUITING

Pécs, 7624, Hungary
Rocky Mountain Cancer Center
RECRUITING

Aurora, Colorado, 80012, United States
Royal Hobart Hospital
RECRUITING

Hobart, 7000, Australia
Royal Victoria Regional Health Centre
RECRUITING

Barrie, L4M 6M2, Canada
Saint Elizabeth Medical Center Edgewood
RECRUITING

Edgewood, Kentucky, 41017, United States
Sakarya University School of Medicine
RECRUITING

Adapazarı, 54100, Turkey (Türkiye)
Samsung Medical Center
RECRUITING

Seoul, 06351, South Korea
Sarah Cannon Research Institute/SCRI
RECRUITING

The Woodlands, Texas, 77380, United States
Saskatoon Cancer Centre
RECRUITING

Saskatoon, S7N4H4, Canada
Semmelweis Egyetem
RECRUITING

Budapest, 1088, Hungary
Seoul National University Hospital
RECRUITING

Seoul, 03080, South Korea
Singleton Hospital
RECRUITING

Swansea, SA2 8QA, United Kingdom
Spitalul Clinic Colțea
RECRUITING

Bucharest, 030171, Romania
Spitalul Clinic Municipal Filantropia Craiova
RECRUITING

Craiova, 200143, Romania
St James's University Hospital
RECRUITING

Leeds, LS9 7TF, United Kingdom
Stanford Cancer Center
RECRUITING

Palo Alto, California, 94304, United States
Szegedi Tudományegyetem Szent-Györgyi Albert Klinikai Központ
RECRUITING

Szeged, 6725, Hungary
The Beatson West of Scotland Cancer Centre
RECRUITING

Glasgow, G12 0YN, United Kingdom
The Catholic Univ. of Korea Seoul St. Mary's Hospital
RECRUITING

Seoul, 06591, South Korea
The Catholic University of Korea, Yeouido St. Mary's Hospital
RECRUITING

Seoul, 07345, South Korea
The Perth Blood Institute - West Perth
RECRUITING

West Perth, 6005, Australia
The West Clinic, PLLC dba West Cancer Center
RECRUITING

Germantown, Tennessee, 38138, United States
USO-Texas Oncology-Central/South Texas
RECRUITING

Austin, Texas, 78705, United States
USO-Virginia Oncology Associates
RECRUITING

Hampton, Virginia, 23666, United States
UZ Gent
RECRUITING

Ghent, 9000, Belgium
UZ Leuven
RECRUITING

Leuven, 3000, Belgium
University of Miami Hospital and Clinics, Sylvester Cancer Center
RECRUITING

Miami, Florida, 33136, United States
Univerzitna Nemocnica L. Pasteura Kosice
RECRUITING

Košice, 040 11, Slovakia
Univerzitna nemocnica Martin
RECRUITING

Martin, 036 59, Slovakia
Uniwersytecki Szpital Kliniczny im. Jana Mikulicza-Radeckiego we Wrocławiu
RECRUITING

Wroclaw, 50-367, Poland
VM Medical Park Mersin Hastanesi
RECRUITING

Mersin, 33200, Turkey (Türkiye)
Vseobecna fakultni nemocnice v Praze
RECRUITING

Prague, 12808, Czechia
Williamette Valley Cancer Institute & Research Center
RECRUITING

Eugene, Oregon, 97401, United States
Yeditepe Üniversitesi Koşuyolu Hastanesi
RECRUITING

Istanbul, 34718, Turkey (Türkiye)

More trials for these conditions

Other studies related to the condition(s) this trial covers.