New combo therapy aims to control blood cancer without a cure

NCT ID NCT06378138

Recruiting now Disease control Sponsor: Beijing InnoCare Pharma Tech Co., Ltd. Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests a new drug combination (ICP-248 plus orelabrutinib) in people with untreated chronic lymphocytic leukemia or small lymphocytic lymphoma. The goal is to see if the combination is safe and tolerable. About 226 adults aged 18 to 80 with measurable disease and a need for treatment will participate. This is not a cure; it aims to control the disease long-term.

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Conditions

The condition(s) this trial relates to.

B-cell chronic lymphocytic leukemia chronic lymphocytic leukemia/small lymphocytic lymphoma hematopoietic and lymphoid system neoplasm

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

HEMATOLOGIC MALIGNANCIES

Contacts and locations

Locations

Anhui Provincial Hospital (The First Affiliated Hospital of University of Science and Technology of China)
RECRUITING

Hefei, Anhui, 230001, China
Bethune First Hospital of Jilin University
RECRUITING

Changchun, Jilin, 130061, China
Blood Diseases Hospital of Chinese Academy of Medical Sciences
RECRUITING

Tianjin, Tianjin Municipality, 300020, China
Changzhou First People's Hospital
NOT_YET_RECRUITING

Changzhou, Jiangsu, 213003, China
Fujian Medical University Union Hospital
RECRUITING

Fuzhou, Fujian, 350001, China
Gansu Provincial People's Hospital
RECRUITING

Lanzhou, Gansu, 730000, China
Guangdong General Hospital
NOT_YET_RECRUITING

Guangzhou, Guangdong, 510080, China
Henan Cancer Hospital
RECRUITING

Zhenzhou, Henan, 450003, China
Henan Provincial People's Hospital
RECRUITING

Zhengzhou, Henan, 463599, China
Huai'an First People's Hospital
RECRUITING

Huai'an, Jiangsu, 223300, China
Huashan Hospital
RECRUITING

Shanghai, Shanghai Municipality, 200040, China
Hunan Cancer Hospital
RECRUITING

Changsha, Hunan, 410031, China
Jiangsu Province Hospital
RECRUITING

Nanjing, Jiangsu, 210029, China
Jining First People's Hospital
RECRUITING

Jining, Shandong, 272011, China
Linyi City Cancer Hospital
RECRUITING

Linyi, Shandong, 276002, China
Nanfang Hospital of Southern Medical University
NOT_YET_RECRUITING

Guangzhou, Guangdong, 510515, China
Nanyang City Center Hospital
RECRUITING

Nanyang, Henan, 473005, China
Peking University Third Hospital
RECRUITING

Beijing, Beijing Municipality, 100191, China
Qilu Hospital of Shandong University
RECRUITING

Jinan, Shandong, 250012, China
Shaanxi Provincial People's Hospital
RECRUITING

Xi’an, Shanxi, 710068, China
Shandong Cancer Hospital
RECRUITING

Jinan, Shandong, 250117, China
Shandong Provincial Hospital
RECRUITING

Jinan, Shandong, 250021, China
Shanghai Huashan Hospital
NOT_YET_RECRUITING

Shanghai, Shanghai Municipality, 201108, China
Shanxi Cancer Hospital
NOT_YET_RECRUITING

Taiyuan, Shanxi, 030013, China
Shengjing Hospital affiliated to China Medical University
RECRUITING

Shenyang, Liaoning, Liaoning, China
Sichuan Provincial People's Hospital
RECRUITING

Chengdu, Sichuan, 610072, China
Sun Yat-sen University Cancer Center
RECRUITING

Guangzhou, Guangdong, 510055, China
The Affiliated Cancer Hospital of Xinjiang Medical University
RECRUITING

Ürümqi, Xinjiang Uygur Autonomous Region, 830000, China
The Affiliated Hospital of North China University of Science and Technology
RECRUITING

Tangshan, Hebei, 063000, China
The Affiliated Hospital of Zunyi Medical University
NOT_YET_RECRUITING

Zunyi, Guizhou, 563003, China
The First Affiliated Hospital of Anhui Medical University
RECRUITING

Hefei, Anhui, 230022, China
The First Affiliated Hospital of Bengbu Medical College
RECRUITING

Bengbu, Anhui, 233004, China
The First Affiliated Hospital of Chongqing Medical University
RECRUITING

Chongqing, Chongqing Municipality, 400016, China
The First Affiliated Hospital of Guangxi Medical University
NOT_YET_RECRUITING

Nanning, Guangxi, 530021, China
The First Affiliated Hospital of Henan University of Science and Technology
RECRUITING

Luoyang, Henan, 471003, China
The First Affiliated Hospital of Kunming Medical University
RECRUITING

Kunming, Yunnan, 650032, China
The First Affiliated Hospital of Nanchang University
RECRUITING

Nanchang, Jiangxi, 330006, China
The First Affiliated Hospital of Xiamen University
RECRUITING

Xiamen, Fujian, 361003, China
The First Affiliated Hospital of Zhejiang University School of Medicine
RECRUITING

Hangzhou, Zhejiang, 310003, China
The Fourth Hospital of Hebei Medical University
RECRUITING

Shijiazhuang, Hebei, 050010, China
The People's Hospital Affiliated to Ningbo University
RECRUITING

Ningbo, Zhejiang, 315040, China
The Second Affiliated Hospital of Xi'an Jiaotong University
RECRUITING

Xi’an, Shanxi, 710004, China
The Second Hospital of Dalian Medical University
RECRUITING

Dalian, Liaoning, 116023, China
The Second Hospital of Shanxi Medical University
NOT_YET_RECRUITING

Taiyuan, Shanxi, 030001, China
The Second Xiangya Hospital, Central South University
RECRUITING

Changsha, Hunan, 410012, China
Tianjin Medical University Cancer Institute and Hospital
RECRUITING

Tianjin, Tianjin Municipality, 300181, China
Tianjin People's Hospital
NOT_YET_RECRUITING

Tianjin, Tianjin Municipality, 300120, China
Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology
RECRUITING

Wuhan, Hubei, 430011, China
Union Hospital Tongji Medical College, Huazhong University of Science and Technology
RECRUITING

Wuhan, Hubei, 430022, China
West China Hospital of Sichuan University
RECRUITING

Chengdu, Sichuan, 610041, China
Xinqiao Hospital, the Second Affiliated Hospital of Army Military Medical University
RECRUITING

Chongqing, Chongqing Municipality, 400037, China
Yibin Second People's Hospital
RECRUITING

Yibin, Sichuan, 644002, China
Yichang Central People's Hospital
RECRUITING

Yichang, Hubei, 443003, China

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