New drug pirtobrutinib tested for Long-Term safety in blood cancers
NCT ID NCT07218341
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study is checking the long-term safety of the drug pirtobrutinib in people with chronic lymphocytic leukemia (CLL) or small lymphocytic lymphoma (SLL) who have already been treated with other drugs. About 150 adults who completed a previous pirtobrutinib study can join. They will take pirtobrutinib by mouth every 4 weeks for up to 5 years, and researchers will track any serious side effects.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
pirtobrutinib
What this could lead to
If successful, this study could confirm that pirtobrutinib is safe for long-term use in people with CLL or SLL, supporting its continued use as a treatment option.
What could go wrong
This is an open-label safety study, not designed to prove effectiveness. Side effects like grade 3 or higher adverse events may occur, and results may not apply to all patients.
Disclaimer
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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AZ Delta
NOT_YET_RECRUITINGRoeselare, 8800, Belgium
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Affiliated Cancer Hospital of Xinjiang Medical University
NOT_YET_RECRUITINGÜrümqi, 830000, China
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Arizona Oncology Associates, P.C. - HOPE
NOT_YET_RECRUITINGTucson, Arizona, 85711, United States
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Azienda Ospedaliera S. Maria Di Terni
NOT_YET_RECRUITINGTerni, 05100, Italy
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Azienda Ospedaliera Universitaria Careggi
NOT_YET_RECRUITINGFlorence, 50134, Italy
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Azienda Ospedaliera Universitaria Integrata Verona - Ospedale Borgo Roma
NOT_YET_RECRUITINGVerona, 37134, Italy
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Azienda Ospedaliera di Perugia Ospedale S. Maria della Misericordia
NOT_YET_RECRUITINGPerugia, 06129, Italy
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Azienda Ospedaliero - Universitaria Nazionale Santi Antonio e Biagio e Cesare Arrigo
NOT_YET_RECRUITINGAlessandria, 15121, Italy
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Beaumont Hospital
NOT_YET_RECRUITINGDublin, DUBLIN 9, Ireland
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Cancer Specialists, LLC
RECRUITINGJacksonville, Florida, 32256, United States
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Castle Hill Hospital
NOT_YET_RECRUITINGHull, HU16 5JQ, United Kingdom
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Cayuga Cancer Center
NOT_YET_RECRUITINGIthaca, New York, 14850, United States
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Centre Henri Becquerel
NOT_YET_RECRUITINGRouen, 76038, France
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Debreceni Egyetem
NOT_YET_RECRUITINGDebrecen, 4032, Hungary
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Del-pesti Centrumkorhaz - Orszagos Hematologiai es Infektologiai Intezet
NOT_YET_RECRUITINGBudapest, 1097, Hungary
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Fakultni nemocnice Hradec Kralove
NOT_YET_RECRUITINGHradec Králové, 500 05, Czechia
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Fondazione IRCCS San Gerardo dei Tintori
NOT_YET_RECRUITINGMonza, 20900, Italy
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Fondazione Policlinico Universitario Agostino Gemelli IRCCS
NOT_YET_RECRUITINGRome, 00138, Italy
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Fudan University Shanghai Cancer Center
NOT_YET_RECRUITINGShanghai, 200032, China
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Gansu Provincial Cancer Hospital
NOT_YET_RECRUITINGLanzhou, 730050, China
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GenesisCare
NOT_YET_RECRUITINGNewmarket, CB8 7XN, United Kingdom
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Hematology Hospital of the Chinese Academy of Medical Sciences
NOT_YET_RECRUITINGTianjin, 300020, China
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Henan Cancer Hospital
NOT_YET_RECRUITINGZhengzhou, 450003, China
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Hospital Universitario Marques De Valdecilla
NOT_YET_RECRUITINGSantander, 39008, Spain
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Hospital Universitario Virgen Del Rocio
NOT_YET_RECRUITINGSeville, 41010, Spain
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Hunan Cancer Hospital
NOT_YET_RECRUITINGChangsha, 410013, China
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Instytut Hermatologii I Transfuzjologii
NOT_YET_RECRUITINGWarsaw, 02-776, Poland
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LKH - Universitätsklinikum der PMU Salzburg
NOT_YET_RECRUITINGSalzburg, 5020, Austria
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Liverpool Hospital
NOT_YET_RECRUITINGLiverpool, 2170, Australia
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Memorial Sloan-Kettering Cancer Center (MSKCC) - New York
RECRUITINGNew York, New York, 10065-6007, United States
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Minnesota Oncology Hematology, P.A.
NOT_YET_RECRUITINGCoon Rapids, Minnesota, 55433, United States
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Mitchell Cancer Institute
NOT_YET_RECRUITINGMobile, Alabama, 36693, United States
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Nanfang Hospital of Southern Medical University
NOT_YET_RECRUITINGGuangzhou, 510515, China
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Oncology Hematology Care Inc
NOT_YET_RECRUITINGCincinnati, Ohio, 45211, United States
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Pratia Onkologia Katowice
NOT_YET_RECRUITINGKatowice, 40-519, Poland
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Presidio Ospedaliero Papardo
NOT_YET_RECRUITINGMessina, 98158, Italy
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Princess Margaret Cancer Centre - University Health Network
NOT_YET_RECRUITINGToronto, M5G 2M9, Canada
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St James's University Hospital
RECRUITINGLeeds, LS9 7TF, United Kingdom
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St. James's Hospital
NOT_YET_RECRUITINGDublin, D08 NHY1, Ireland
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Sun Yat-sen University Cancer Center
NOT_YET_RECRUITINGGuangdong, 510060, China
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Szpital Specjalistyczny w Brzozowie Podkarpacki Ośrodek Onkologiczny im.ks.B.Markiewicza
NOT_YET_RECRUITINGBrzozów, 36-200, Poland
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Szpital Uniwersytecki Nr 2 im. dr J. Biziela w Bydgoszczy
NOT_YET_RECRUITINGBydgoszcz, 85-168, Poland
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Taizhou Hospital of Zhejiang Province
NOT_YET_RECRUITINGTaizhou, 317000, China
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Tel Aviv Sourasky Medical Center
NOT_YET_RECRUITINGTel Aviv, 6423906, Italy
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Texas Oncology - Paris
NOT_YET_RECRUITINGFort Worth, Texas, 76104, United States
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The Affiliated Hospital of Xuzhou Medical College
NOT_YET_RECRUITINGXuzhou, 221000, China
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The Alfred Hospital
NOT_YET_RECRUITINGMelbourne, 3004, Australia
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The First Affiliated Hospital of Nanchang University
NOT_YET_RECRUITINGNanchang, 330006, China
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Tianjin Medical University Cancer Institute & Hospital
NOT_YET_RECRUITINGTianjin, 300060, China
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Tokai University Hospital
RECRUITINGIsehara, 259-1193, Japan
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US Oncology - Texas Oncology
NOT_YET_RECRUITINGKyle, Texas, 78640, United States
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University Hospital Center Zagreb
NOT_YET_RECRUITINGZagreb, 10000, Croatia
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Xuanwu Hospital Capital Medical University
NOT_YET_RECRUITINGBeijing, 100053, China
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