New hope for Hard-to-Treat leukemia: Two-Drug combo enters human trials
NCT ID NCT05091424
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This early-stage trial is testing two drugs, mosunetuzumab and venetoclax, in people with chronic lymphocytic leukemia (CLL) that has come back or stopped responding to treatment. Mosunetuzumab is given as a shot under the skin, and venetoclax is a daily pill. The study will check for safety, side effects, and whether the drugs help shrink the cancer. About 137 participants will take part.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
mosunetuzumab (Lunsumio) and venetoclax (Venclexta)
What this could lead to
If successful, this could offer a new treatment option for people with CLL that has stopped responding to other therapies.
What could go wrong
This is an early Phase 1 trial focused on safety, so it is too soon to know if the drugs will work. Side effects like cytokine release syndrome are possible.
Disclaimer
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This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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A.O. Spedali Civili Di Brescia-P.O. Spedali Civili
RECRUITINGBrescia, Lombardy, 25123, Italy
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Asst Grande Ospedale Metropolitano Niguarda
RECRUITINGMilan, Lombardy, 20162, Italy
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Azienda Ospedaliera Di Perugia Ospedale s. Maria Della Misericordia
RECRUITINGSant'Andrea Delle Fratte (PG), Umbria, 06132, Italy
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Christie Hospital NHS Trust
RECRUITINGManchester, M20 4BX, United Kingdom
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Chu de Clermont Ferrand
WITHDRAWNClermont-Ferrand, 63003, France
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Churchill Hospital
RECRUITINGOxford, OX3 7LE, United Kingdom
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Hospital Universitari Vall d'Hebron
RECRUITINGBarcelona, 08035, Spain
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Hospital de la Santa Creu i Sant Pau
RECRUITINGBarcelona, 08025, Spain
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Huntsman Cancer Institute at The University of Utah
RECRUITINGSalt Lake City, Utah, 84112, United States
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IUCT Oncopole
WITHDRAWNToulouse, 31059, France
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Mayo Clinic Rochester
RECRUITINGRochester, Minnesota, 55902, United States
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Memorial Sloan-Kettering Cancer Center
WITHDRAWNNew York, New York, 10065, United States
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Monash Medical Centre
RECRUITINGMelbourne, Victoria, 3168, Australia
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Osp. San Raffaele
RECRUITINGMilan, Lombardy, 20132, Italy
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PRATIA MCM Kraków
RECRUITINGKrakow, 30-727, Poland
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Peking University People's Hospital
RECRUITINGBeijing, 100044, China
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Peter MacCallum Cancer Center
COMPLETEDEast Melbourne, Victoria, 3002, Australia
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Princess Alexandra Hospital Woolloongabba
RECRUITINGWoolloongabba, Queensland, 4102, Australia
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Seoul National University Hospital
RECRUITINGSeoul, 03080, South Korea
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Seoul St Mary's Hospital
RECRUITINGSeoul, 06591, South Korea
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Southern Medical University Nanfang Hospital
RECRUITINGGuangzhou, 510515, China
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The First Affiliated Hospital of Nanchang University
RECRUITINGNanchang, China
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The James Cancer Hospital and Solove Research Institute
RECRUITINGColumbus, Ohio, 43210, United States
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Tianjin Institute of Hematology & Blood Diseases Hospital
RECRUITINGTianjin, 301600, China
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Uni of Texas - Md Anderson Cancer Center
WITHDRAWNHouston, Texas, 77030, United States
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Uniklinik Koln
WITHDRAWNCologne, 50937, Germany
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Universitätsklinikum Augsburg
RECRUITINGAugsburg, 86156, Germany
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Universitätsklinikum Ulm
RECRUITINGUlm, 89081, Germany
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Uniwersytecki Szpital Kliniczny im. Jana Mikulicza-Radeckiego we Wroclawiu
RECRUITINGWroc?aw, 50-367, Poland
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Uniwersyteckie Centrum Kliniczne
RECRUITINGGda?sk, 80-214, Poland
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Yeouido St. Mary's Hospital
RECRUITINGSeoul, 07345, South Korea