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Scientists hunt for clues to CLL drug resistance in new study

NCT ID NCT07099443

Recruiting now Knowledge-focused Sponsor: Nantes University Hospital Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jul 09, 2026 · Updated 2 times

Summary

This study aims to understand why some people with chronic lymphocytic leukemia (CLL) respond well to a new class of drugs called BTK degraders, while others do not. Researchers will collect blood, bone marrow, or lymph node samples from 60 patients over 9 years and follow them for 5 years. The goal is to identify resistance mechanisms using advanced lab techniques, which may help improve future treatments.

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Conditions

The condition(s) this trial relates to.

B-cell chronic lymphocytic leukemia

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

BTK DEGRADERS CHRONIC LYMPHOCYTIC LEUKEMIA REFRACTORY CHRONIC LYMPHOCYTIC LEUKEMIA

Contacts and locations

Locations

  • CH Régional Universitaire de Nancy

    NOT_YET_RECRUITING

    Nancy, France

  • CHD Vendée

    RECRUITING

    La Roche-sur-Yon, France

  • CHU de Angers

    NOT_YET_RECRUITING

    Angers, France

  • CHU de Bordeaux

    NOT_YET_RECRUITING

    Bordeaux, France

  • CHU de Clermont-Ferrand

    NOT_YET_RECRUITING

    Clermont-Ferrand, France

  • CHU de Montpellier

    NOT_YET_RECRUITING

    Montpellier, France

  • CHU de Poitiers

    NOT_YET_RECRUITING

    Poitiers, France

  • Centre Henri-Becquerel de Rouen

    NOT_YET_RECRUITING

    Rouen, France

  • Centre Léon Bernard

    NOT_YET_RECRUITING

    Lyon, France

  • Hôpital Avicenne (AP-HP)

    NOT_YET_RECRUITING

    Paris, France

  • Hôpital Universitaire Pitié Salpêtrière de Paris

    NOT_YET_RECRUITING

    Paris, France

  • Institut Bergonié

    NOT_YET_RECRUITING

    Bordeaux, France

  • Institut Paoli-Calmettes (Marseille)

    NOT_YET_RECRUITING

    Marseille, France

  • University Hospital

    RECRUITING

    Nantes, France

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