Blood cancer Patients' vaccine response under the microscope

NCT ID NCT05170399

Recruiting now Knowledge-focused Sponsor: National Heart, Lung, and Blood Institute (NHLBI) Source: ClinicalTrials.gov ↗

First seen Jun 24, 2026 · Last updated Jul 24, 2026 · Updated 6 times

Summary

This study looks at how well vaccines for flu, COVID-19, shingles, hepatitis B, and pneumonia work in people with certain blood cancers like chronic lymphocytic leukemia (CLL) and non-Hodgkin lymphomas. Researchers will measure immune responses through blood samples before and after vaccination. Up to 500 adults will participate, and some may pause their cancer treatment temporarily to see if that improves vaccine effectiveness.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: vaccines (influenza, shingles, pneumococcal, hepatitis B, COVID-19)
What this could lead to: If successful, this could help doctors recommend better vaccine schedules for people with blood cancers, potentially improving protection against preventable diseases.
What could go wrong: This is an observational study, not testing a new treatment. Results may not apply to all blood cancer patients, and vaccine responses may still be weak in some individuals.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

B-cell chronic lymphocytic leukemia follicular lymphoma lymphoma mantle cell lymphoma marginal zone lymphoma non-Hodgkin lymphoma Waldenstrom macroglobulinemia

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

LYMPHOMA

Contacts and locations

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Study contacts

Contact

Phone: •••-•••-•••• Email: •••••@•••••
Contact

Phone: •••-•••-•••• Email: •••••@•••••

Locations

National Institutes of Health Clinical Center
RECRUITING

Bethesda, Maryland, 20892, United States

Contact Phone: •••-•••-•••• Email: •••••@•••••

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