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New dosing strategy aims to reduce dangerous side effect in blood cancer treatment

NCT ID NCT06697184

Recruiting now Disease control Sponsor: BeOne Medicines Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Aug 11, 2026 · Updated 2 times

Summary

This study tests new ways to give the drug sonrotoclax to adults with chronic lymphocytic leukemia or mantle cell lymphoma. The goal is to find a dosing schedule that lowers the risk of tumor lysis syndrome, a serious side effect. About 258 participants will be enrolled to check safety and tolerability.

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Conditions

The condition(s) this trial relates to.

B-cell chronic lymphocytic leukemia hematopoietic and lymphoid system neoplasm mantle cell lymphoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

CHRONIC LYMPHOCYTIC LEUKEMIA CLL MANTLE CELL LYMPHOMA MCL

Contacts and locations

Study contacts

  • Contact

    Email: •••••@•••••

Locations

  • Blacktown Cancer and Haematology Centre

    RECRUITING

    Blacktown, New South Wales, NSW 2148, Australia

  • Cabrini Hospital Malvern

    RECRUITING

    Malvern, Victoria, VIC 3144, Australia

  • Chu Dijon

    RECRUITING

    Dijon, 21000, France

  • Chu Montpellier Hopital Saint Eloi

    RECRUITING

    Montpellier, 34090, France

  • Dana Farber Cancer Institute

    RECRUITING

    Boston, Massachusetts, 02215-5418, United States

  • Fort Wayne Medical Oncology and Hematology

    RECRUITING

    Fort Wayne, Indiana, 46804, United States

  • Fred Hutchinson Cancer Research Center

    RECRUITING

    Seattle, Washington, 98109-4433, United States

  • Genesiscare St Andrews

    RECRUITING

    Adelaide, South Australia, SA 5000, Australia

  • Iuct Oncopole

    RECRUITING

    Toulouse, 31100, France

  • Linear Clinical Research

    RECRUITING

    Nedlands, Western Australia, WA 6009, Australia

  • Moffitt Cancer Center

    RECRUITING

    Tampa, Florida, 33612-9496, United States

  • Queen Elizabeth Hospital

    RECRUITING

    Birmingham, B15 2TH, United Kingdom

  • Rockingham Hospital

    RECRUITING

    Cooloongup, Western Australia, WA 6168, Australia

  • St Jamess University Hospital

    RECRUITING

    Leeds, LS9 7TF, United Kingdom

  • The Alfred Hospital

    RECRUITING

    Melbourne, Victoria, VIC 3004, Australia

  • The University of Kansas Cancer Center

    RECRUITING

    Westwood, Kansas, 66205-2003, United States

  • Washington University School of Medicine

    RECRUITING

    St Louis, Missouri, 63110-1010, United States

More trials for these conditions

Other studies related to the condition(s) this trial covers.