Cure My Disease

Don't miss your cure!

 Log in / Sign up

New combo therapy takes on tough lymphoma

NCT ID NCT05873712

Recruiting now Disease control Sponsor: Aseel Alsouqi Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests a combination of two treatments—zanubrutinib (a targeted drug) and lisocabtagene maraleucel (a CAR T-cell therapy)—for people with Richter's syndrome, an aggressive lymphoma that can develop from chronic lymphocytic leukemia. The goal is to see if this combo can shrink tumors in patients whose cancer has returned or stopped responding to other treatments. About 24 adults will take part in this phase 2 trial.

Disclaimer Read more

This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

Get updates

Get notified about this study

Sign up to get updates when this study changes or when new studies for DIFFUSE LARGE B-CELL LYMPHOMA are added.

Our safety recommendation!

By submitting, you agree to our Terms of use

Conditions

The condition(s) this trial relates to.

B-cell chronic lymphocytic leukemia B-cell non-Hodgkin lymphoma diffuse large B-cell lymphoma non-Hodgkin lymphoma refractory malignant neoplasm relapsed/refractory diffuse large B-cell lymphoma Richter transformation

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

RECURRENT TRANSFORMED B-CELL NON-HODGKIN LYMPHOMA RECURRENT TRANSFORMED CHRONIC LYMPHOCYTIC LEUKEMIA RECURRENT TRANSFORMED NON-HODGKIN LYMPHOMA REFRACTORY TRANSFORMED REFRACTORY TRANSFORMED B-CELL NON-HODGKIN LYMPHOMA REFRACTORY TRANSFORMED CHRONIC LYMPHOCYTIC LEUKEMIA REFRACTORY TRANSFORMED NON-HODGKIN LYMPHOMA TRANSFORMED CHRONIC LYMPHOCYTIC LEUKEMIA TO DIFFUSE LARGE B-CELL LYMPHOMA

Contacts and locations

Study contacts

  • Contact

    Phone: •••-•••-•••• Email: •••••@•••••

Locations

  • Huntsman Cancer Institute

    RECRUITING

    Salt Lake City, Utah, 84112, United States

    Contact

    Contact Phone: •••-•••-•••• Email: •••••@•••••

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • Icahn School of Medicine at Mount Sinai

    RECRUITING

    New York, New York, 10029, United States

    Contact

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • Ohio State University Comprehensive Cancer Center

    RECRUITING

    Columbus, Ohio, 43210, United States

    Contact Phone: •••-•••-•••• Email: •••••@•••••

    Contact