New drug aims to wipe out cancer protein in Tough-to-Treat blood cancers

NCT ID NCT05006716

Recruiting now Disease control Sponsor: BeOne Medicines Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Aug 07, 2026 · Updated 5 times

Summary

This study tests a new oral drug, BGB-16673, designed to destroy a protein called BTK that helps certain blood cancers grow. The trial includes about 645 people with various B-cell cancers (like lymphoma and leukemia) that have come back or not responded to prior treatments. The goal is to find the safest dose and see if the drug can shrink tumors.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: BGB-16673 (a drug that destroys a protein called BTK, which helps some blood cancers grow)
What this could lead to: If it works, this could offer a new treatment option for people with B-cell cancers that have stopped responding to other therapies.
What could go wrong: This is an early-phase trial (Phase 1/2), so the drug may not work or could cause serious side effects. It is also only for people whose cancer has returned or not responded to prior treatments.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

B-cell chronic lymphocytic leukemia B-cell neoplasm diffuse large B-cell lymphoma follicular lymphoma Lymphoma, B-Cell, Marginal Zone mantle cell lymphoma marginal zone lymphoma non-Hodgkin lymphoma relapsed/refractory diffuse large B-cell lymphoma Richter transformation Waldenstrom macroglobulinemia

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

B-CELL MALIGNANCY CHRONIC LYMPHOCYTIC LEUKEMIA DIFFUSE LARGE B-CELL LYMPHOMA FOLLICULAR LYMPHOMA MANTLE CELL LYMPHOMA MARGINAL ZONE LYMPHOMA NON-HODGKIN LYMPHOMA SMALL LYMPHOCYTIC LYMPHOMA WALDENSTRÖM MACROGLOBULINEMIA

Contacts and locations

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Study contacts

Contact

Email: •••••@•••••

Locations

Aichi Cancer Center Hospital Clinical Oncology
RECRUITING

Nagoya, Aichi-ken, 464-8681, Japan
American Oncology Partners of Maryland Pa
RECRUITING

Bethesda, Maryland, 20817-7847, United States
Arensia Exploratory Medicine Llc
ACTIVE_NOT_RECRUITING

Tbilisi, 0112, Georgia
Arthur Je Child Comprehensive Cancer Centre
RECRUITING

Calgary, Alberta, T2N 5G2, Canada
Asan Medical Center
RECRUITING

SongpaGu, Seoul Teugbyeolsi, 05505, South Korea
Augusta University
RECRUITING

Augusta, Georgia, 30912-0002, United States
Austin Health
RECRUITING

Heidelberg, Victoria, VIC 3084, Australia
British Columbia Cancer Agency the Vancouver Centre
RECRUITING

Vancouver, British Columbia, V5Z 4E6, Canada
Calvary Mater Newcastle
RECRUITING

Waratah, New South Wales, NSW 2298, Australia
Cancer Institute Hospital of Jfcr
RECRUITING

Kotoku, Tokyo, 135-8550, Japan
Centre Henri Becquerel
RECRUITING

Rouen, 76038, France
Centre Leon Berard
RECRUITING

Lyon, 69373, France
Centre de Lutte Contre Le Cancer Institut Bergonie
RECRUITING

Bordeaux, 33076, France
Centro Gaucho Integrado de Oncologia Hospital Mae de Deus
RECRUITING

Porto Alegre, 90110-270, Brazil
Centroricerche Cliniche Di Verona Srl
RECRUITING

Verona, 37134, Italy
Chiba Cancer Center
RECRUITING

Chiba, Chiba, 260-8717, Japan
Chu Henri Mondor
RECRUITING

Créteil, 94000, France
Chu Montpellier Hopital Saint Eloi
RECRUITING

Montpellier, 34090, France
Chu de Quebec Universite Laval, Hopital de Lenfant Jesus, Centre Integre de Cancerologie (Cic)
RECRUITING

Québec, Quebec, G1J 1Z4, Canada
Columbia University Medical Center
RECRUITING

New York, New York, 10032, United States
Comprehensive Cancer Centers of Nevada
RECRUITING

Las Vegas, Nevada, 89169-3321, United States
Concord Repatriation General Hospital
RECRUITING

Concord, New South Wales, NSW 2139, Australia
Cross Cancer Institute
RECRUITING

Edmonton, Alberta, T6G 1Z2, Canada
Dana Farber Cancer Institute
RECRUITING

Boston, Massachusetts, 02215-5418, United States
Derriford Hospital
RECRUITING

Plymouth, PL6 8DH, United Kingdom
Dokuz Eylul University
RECRUITING

Balçova, 35330, Turkey (Türkiye)
Edinburgh Cancer Centre
RECRUITING

Edinburgh, EH4 2XU, United Kingdom
Erciyes University
RECRUITING

Kayseri, 38030, Turkey (Türkiye)
Fondazione Policlinico Universitario Agostino Gemelli
RECRUITING

Roma, 00168, Italy
Fred Hutchinson Cancer Research Center
RECRUITING

Seattle, Washington, 98109-4433, United States
Freeman Hospital
RECRUITING

Newcastle upon Tyne, NE7 7DN, United Kingdom
Genesiscare Cambridge
RECRUITING

Newmarket, CB8 7XN, United Kingdom
Henan Cancer Hospital
ACTIVE_NOT_RECRUITING

Zhengzhou, Henan, 450000, China
Honor Health Research Institute
RECRUITING

Scottsdale, Arizona, 85258-4566, United States
Hopital Claude Huriez Chu Lille
RECRUITING

Lille, 59000, France
Hopital Estaing
RECRUITING

ClermontFerrand, 63100, France
Hopital de La Pitie Salpetriere
RECRUITING

Paris, 75013, France
Hospital Clinico Universitario de Valencia
RECRUITING

Valencia, 46010, Spain
Hospital Erasto Gaertner
RECRUITING

Curitiba, 81520-060, Brazil
Hospital General Universitario Gregorio Maranon
RECRUITING

Madrid, 28007, Spain
Hospital Nove de Julho Dasa
RECRUITING

São Paulo, 01409-001, Brazil
Hospital Sirio Libanes Brasilia
RECRUITING

Brasília, 70200-730, Brazil
Hospital Universitario Fundacion Jimenez Diaz
RECRUITING

Madrid, 28040, Spain
Hospital Universitario La Paz
RECRUITING

Madrid, 28046, Spain
Hospital Universitario Puerta de Hierro Majadahonda
RECRUITING

Majadahonda, 28222, Spain
Hospital Universitario Vall Dhebron
RECRUITING

Barcelona, 08035, Spain
Inje University Busan Paik Hospital
RECRUITING

BusanjinGu, Busan Gwang'Yeogsi, 47392, South Korea
Institut Paoli Calmettes
RECRUITING

Marseille, 13009, France
Institute of Hematology and Blood Diseases Hospital, Chinese Academy of Medical Sciencestuanbo Branch
ACTIVE_NOT_RECRUITING

Tianjin, Tianjin Municipality, 301617, China
Instituto Dor de Pesquisa E Ensino Sao Paulo
RECRUITING

São Paulo, 01401-004, Brazil
Istituto Europeo Di Oncologia
RECRUITING

Milan, 20141, Italy
Karmanos Cancer Institute
RECRUITING

Detroit, Michigan, 48201-2013, United States
Karolinska Universitetssjukhuset Solna
RECRUITING

Stockholm, 171 76, Sweden
Klinikum Grosshadern Ludwig Maximilians Universitat Munchen
RECRUITING

München, 81377, Germany
Klinikum Johannes Gutenberg Universitaet Mainz
RECRUITING

Mainz, 55131, Germany
Linear Clinical Research
RECRUITING

Nedlands, Western Australia, WA 6009, Australia
Mary Bird Perkins Cancer Center
RECRUITING

Baton Rouge, Louisiana, 70809-3738, United States
Mayo Clinic Jacksonville
RECRUITING

Jacksonville, Florida, 32224-1865, United States
Mayo Clinic Phoenix
COMPLETED

Phoenix, Arizona, 85054-4502, United States
Mayo Clinic Rochester
RECRUITING

Rochester, Minnesota, 55905-0001, United States
Md Anderson Cancer Center
RECRUITING

Houston, Texas, 77030-3907, United States
Md Anderson Cancer Center Madrid Spain
RECRUITING

Madrid, 28033, Spain
Memorial Sloan Kettering Cancer Center Mskcc
RECRUITING

New York, New York, 10065-6800, United States
Midwestern Regional Medical Center
COMPLETED

Zion, Illinois, 60099-2676, United States
Mount Sinai Medical Center Braman Comprehensive Cancer Center
RECRUITING

Miami, Florida, 33140, United States
Nanfang Hospital, Southern Medical University
ACTIVE_NOT_RECRUITING

Guangzhou, Guangdong, 510515, China
National Cancer Center Hospital East
RECRUITING

Kashiwa, Chiba, 277-8577, Japan
Niguarda Cancer Center Division of Hematology
RECRUITING

Milan, 20162, Italy
Norton Cancer Institute Pavilion
ACTIVE_NOT_RECRUITING

Louisville, Kentucky, 40207-4700, United States
Nottingham University Hospitals Nhs Trust
RECRUITING

Nottingham, NG5 1PB, United Kingdom
Ondokuz Mayis University
RECRUITING

Samsun, 55200, Turkey (Türkiye)
Ospedale San Raffaele
RECRUITING

Milan, 20132, Italy
Peking Union Medical College Hospital
ACTIVE_NOT_RECRUITING

Beijing, Beijing Municipality, 100730, China
Perth Blood Institute
RECRUITING

West Perth, Western Australia, WA 6005, Australia
Peter Maccallum Cancer Centre
RECRUITING

Melbourne, Victoria, VIC 3000, Australia
Policlinico Sorsola Malpighi, Aou Di Bologna
RECRUITING

Bologna, 40138, Italy
Princess Alexandra Hospital
RECRUITING

Woolloongabba, Queensland, QLD 4102, Australia
Princess Margaret Cancer Centre
RECRUITING

Toronto, Ontario, M5G 2M9, Canada
Pusan National University Hospital
RECRUITING

Seogu, Busan Gwang'Yeogsi, 49241, South Korea
Real E Benemerita Associacao Portuguesa de Sao Paulo
RECRUITING

São Paulo, 01321-001, Brazil
Roswell Park Comprehensive Cancer Center
RECRUITING

Buffalo, New York, 14203, United States
Rui Jin Hospital Shanghai Jiao Tong University School of Medicine
ACTIVE_NOT_RECRUITING

Shanghai, Shanghai Municipality, 200025, China
Sahlgrenska University Hospital Hematology
RECRUITING

Gothenburg, 413 46, Sweden
Sakarya Training and Research Hospital
RECRUITING

Sakarya, 54100, Turkey (Türkiye)
Samsung Medical Center
RECRUITING

GangnamGu, Seoul Teugbyeolsi, 06351, South Korea
Seoul National University Hospital
RECRUITING

Seoul, Seoul Teugbyeolsi, 03080, South Korea
Severance Hospital Yonsei University Health System
RECRUITING

SeodaemunGu, Seoul Teugbyeolsi, 03722, South Korea
Sociedade Beneficente Israelita Brasileira Hospital Albert Einstein
RECRUITING

São Paulo, 05652-900, Brazil
Southeastern Regional Medical Center
RECRUITING

Newnan, Georgia, 30265-8001, United States
St Jamess University Hospital
RECRUITING

Leeds, LS9 7TF, United Kingdom
St Vincents Hospital Melbourne
RECRUITING

Fitzroy, Victoria, VIC 3065, Australia
Stanford Medicine
RECRUITING

Palo Alto, California, 94304-2205, United States
Tampa General Hospital Cancer Institute
RECRUITING

Tampa, Florida, 33606-3571, United States
Tennesse Oncology Chattanooga Downtown
RECRUITING

Chattanooga, Tennessee, 37404, United States
Tennessee Oncology, Pllc Nashville
RECRUITING

Nashville, Tennessee, 37203, United States
The Alfred Hospital
RECRUITING

Melbourne, Victoria, VIC 3004, Australia
The Catholic University of Korea, Seoul St Marys Hospital
RECRUITING

SeochoGu, Seoul Teugbyeolsi, 06591, South Korea
The First Affiliated Hospital of Wenzhou Medical University
ACTIVE_NOT_RECRUITING

Wenzhou, Zhejiang, 325000, China
The Institute of Oncology, Arensia Exploratory Medicine
ACTIVE_NOT_RECRUITING

Chisinau, 2025, Moldova
UCLA Santa Monica Cancer Care
RECRUITING

Santa Monica, California, 90404-2023, United States
Uchealth North
RECRUITING

Fort Collins, Colorado, 80528-3413, United States
Uniklinik Koeln (Aoer)
RECRUITING

Cologne, 50937, Germany
Universitaetsklinikum Schleswig Holstein Campus Luebeck
RECRUITING

Lübeck, 23538, Germany
Universitaetsklinikum Ulm
RECRUITING

Ulm, 89081, Germany
Universitares Krebszentrum Leipzig
RECRUITING

Leipzig, 04103, Germany
Universitatsklinikum Carl Gustav Carus An Der Technischen Universitat Dresden
RECRUITING

Dresden, 01307, Germany
University of Alabama At Birmingham Hospital
RECRUITING

Birmingham, Alabama, 35294-0004, United States
University of Arizona Cancer Center
RECRUITING

Tucson, Arizona, 85724-0001, United States
University of California San Diego (Ucsd) Moores Cancer Center
RECRUITING

La Jolla, California, 92093-1503, United States
University of Iowa Hospitals and Clinics
RECRUITING

Iowa City, Iowa, 52242-1009, United States
Virginia Commonwealth University Massey Cancer Center
RECRUITING

Richmond, Virginia, 23298, United States
Weill Cornell Medical College Newyork Presbyterian Hospital
RECRUITING

New York, New York, 10065-4870, United States
Yichang Central Peoples Hospitaljiangnan Branch
ACTIVE_NOT_RECRUITING

Yichang, Hubei, 443001, China
Yokohama Municipal Citizens Hospital
RECRUITING

Yokohama, 221-0855, Japan

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