New combo aims to put CLL into deep remission and let patients stop treatment

NCT ID NCT06544785

Recruiting now Disease control Sponsor: PETHEMA Foundation Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This phase 2 trial is testing two targeted drugs, zanubrutinib and obinutuzumab, in people with previously untreated chronic lymphocytic leukemia (CLL) or small lymphocytic lymphoma (SLL). The goal is to see if starting obinutuzumab at different times leads to deep remission where no cancer cells can be found. If that happens, patients may be able to stop treatment. About 106 adults will take part.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: zanubrutinib and obinutuzumab
What this could lead to: If successful, this could show that a combination of two targeted drugs can achieve deep remission in CLL/SLL, allowing some patients to safely stop treatment.
What could go wrong: This is a phase 2 trial with only 106 participants, so results are preliminary. The best dosing schedule is unknown, and not all patients will achieve deep remission. Side effects from the drugs are possible.

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Conditions

The condition(s) this trial relates to.

B-cell chronic lymphocytic leukemia

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

CHRONIC LYMPHOCYTIC LEUKEMIA SMALL LYMPHOCYTIC LYMPHOMA

Contacts and locations

Locations

Complexo Hospitalario Universitario de Vigo (CHUVI)
RECRUITING

Vigo, Spain
H Clínico Universitario Valencia
RECRUITING

Valencia, 46010, Spain
H. Clínic de Barcelona
RECRUITING

Barcelona, Spain
H. Clínico Univ. de Navarra
RECRUITING

Pamplona, Spain
H. Clínico Univ. de Salamanca
RECRUITING

Salamanca, Spain
H. General Univ. de Alicante
RECRUITING

Alicante, Spain
H. Son Espases
RECRUITING

Palma de Mallorca, Spain
H. Vall d' Hebron
RECRUITING

Barcelona, Spain
Hospital Costa del Sol
RECRUITING

Marbella, Spain
Hospital Infanta Leonor
RECRUITING

Madrid, Spain
Hospital Marqués de Valdecilla
RECRUITING

Santander, Spain
Hospital Regional Universitario de Málaga
RECRUITING

Málaga, Spain
Hospital Santa Creu i Sant Pau
RECRUITING

Barcelona, Spain
Hospital Universitario Central de Asturias
RECRUITING

Oviedo, Spain
Hospital Universitario Reina Sofía
RECRUITING

Córdoba, Spain
Hospital Universitario Virgen de Valme
RECRUITING

Seville, Spain
Hospital Universitario de Gran Canaria Doctor Negrín
RECRUITING

Las Palmas de Gran Canaria, Spain
Hospital de Vigo
RECRUITING

Vigo, Spain
Hospital del Mar
RECRUITING

Barcelona, Spain

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