Triple therapy may extend lives in advanced prostate cancer

NCT ID NCT06931340

Recruiting now Disease control Sponsor: Alliance for Clinical Trials in Oncology Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Aug 06, 2026 · Updated 3 times

Summary

This study tests whether adding the chemotherapy drug docetaxel to the usual hormone therapy and apalutamide helps men with prostate cancer that has spread to other parts of the body live longer. About 1,260 men will be randomly assigned to receive either the three-drug combination or the standard two drugs alone. The goal is to see if the extra drug improves overall survival.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

metastatic prostate carcinoma prostate cancer

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

CASTRATION-SENSITIVE PROSTATE CARCINOMA METASTATIC PROSTATE ADENOCARCINOMA STAGE IVB PROSTATE CANCER AJCC V8

Contacts and locations

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Locations

Allegheny General Hospital
RECRUITING

Pittsburgh, Pennsylvania, 15212, United States
Allegheny Valley Hospital
RECRUITING

Natrona Heights, Pennsylvania, 15065, United States
Ascension All Saints Hospital-Spring Street-Racine
RECRUITING

Racine, Wisconsin, 53405, United States
Ascension Calumet Hospital-Chilton
RECRUITING

Chilton, Wisconsin, 53014, United States
Ascension Columbia Saint Mary's Hospital-Milwaukee Campus
RECRUITING

Milwaukee, Wisconsin, 53211, United States
Ascension Columbia Saint Mary's Hospital-Ozaukee Campus-Mequon
RECRUITING

Mequon, Wisconsin, 53097, United States
Ascension Northeast Wisconsin-Mercy Hospital-Oshkosh
RECRUITING

Oshkosh, Wisconsin, 54904, United States
Ascension Northeast Wisconsin-Saint Elizabeth Cancer Center-Appleton
RECRUITING

Appleton, Wisconsin, 54915, United States
Ascension Southeast Wisconsin Hospital-Elmbrook Campus-Brookfield
RECRUITING

Brookfield, Wisconsin, 53045, United States
Ascension Southeast Wisconsin Hospital-Mayfair Road-Wauwatosa
RECRUITING

Wauwatosa, Wisconsin, 53226, United States
Asplundh Cancer Pavilion
RECRUITING

Willow Grove, Pennsylvania, 19090, United States

Contact Email: •••••@•••••
Banner University Medical Center - Tucson
RECRUITING

Tucson, Arizona, 85719, United States
Bayhealth Hospital Kent Campus
ACTIVE_NOT_RECRUITING

Dover, Delaware, 19901, United States
Bayhealth Hospital Sussex Campus
ACTIVE_NOT_RECRUITING

Milford, Delaware, 19963, United States
Benefis Sletten Cancer Institute
RECRUITING

Great Falls, Montana, 59405, United States

Contact Email: •••••@•••••
Billings Clinic Cancer Center
RECRUITING

Billings, Montana, 59101, United States

Contact Email: •••••@•••••
Bozeman Health Deaconess Hospital
RECRUITING

Bozeman, Montana, 59715, United States

Contact Email: •••••@•••••
Cancer Care Center of O'Fallon
RECRUITING

O'Fallon, Illinois, 62269, United States
Cancer Care Specialists of Illinois - Decatur
RECRUITING

Decatur, Illinois, 62526, United States
Carle BroMenn Medical Center
RECRUITING

Normal, Illinois, 61761, United States

Contact Email: •••••@•••••
Carle Cancer Center
RECRUITING

Urbana, Illinois, 61801, United States

Contact Email: •••••@•••••
Carle Cancer Institute Normal
RECRUITING

Normal, Illinois, 61761, United States

Contact Email: •••••@•••••
Carle Physician Group-Effingham
RECRUITING

Effingham, Illinois, 62401, United States

Contact Email: •••••@•••••
Carle Physician Group-Mattoon/Charleston
RECRUITING

Mattoon, Illinois, 61938, United States

Contact Email: •••••@•••••
Carle at The Riverfront
RECRUITING

Danville, Illinois, 61832, United States

Contact Email: •••••@•••••
Central Vermont Medical Center/National Life Cancer Treatment
RECRUITING

Berlin Corners, Vermont, 05602, United States
Centralia Oncology Clinic
RECRUITING

Centralia, Illinois, 62801, United States
Coborn Cancer Center at Saint Cloud Hospital
RECRUITING

Saint Cloud, Minnesota, 56303, United States

Contact Email: •••••@•••••
Community Hospital of Anaconda
RECRUITING

Anaconda, Montana, 59711, United States

Contact Email: •••••@•••••
Community Medical Center
RECRUITING

Missoula, Montana, 59804, United States

Contact Email: •••••@•••••
Crossroads Cancer Center
RECRUITING

Effingham, Illinois, 62401, United States
Decatur Memorial Hospital
RECRUITING

Decatur, Illinois, 62526, United States
Drexel Town Square Health Center
RECRUITING

Oak Creek, Wisconsin, 53154, United States
Duke University Medical Center
RECRUITING

Durham, North Carolina, 27710, United States
Durham VA Medical Center
RECRUITING

Durham, North Carolina, 27705, United States

Contact Email: •••••@•••••
Eisenhower Medical Center
RECRUITING

Rancho Mirage, California, 92270, United States
FirstHealth of the Carolinas-Moore Regional Hospital
RECRUITING

Pinehurst, North Carolina, 28374, United States
Forbes Hospital
RECRUITING

Monroeville, Pennsylvania, 15146, United States
Froedtert Menomonee Falls Hospital
RECRUITING

Menomonee Falls, Wisconsin, 53051, United States
Froedtert West Bend Hospital/Kraemer Cancer Center
RECRUITING

West Bend, Wisconsin, 53095, United States
Froedtert and MCW Moorland Reserve Health Center
RECRUITING

New Berlin, Wisconsin, 53151, United States
Genesys Hurley Cancer Institute
RECRUITING

Flint, Michigan, 48503, United States
Guthrie Cortland Memorial Hospital
RECRUITING

Cortland, New York, 13045, United States
Guthrie Medical Group PC-Robert Packer Hospital
RECRUITING

Sayre, Pennsylvania, 18840, United States
HSHS Saint Elizabeth's Hospital
RECRUITING

O'Fallon, Illinois, 62269, United States
HaysMed
RECRUITING

Hays, Kansas, 67601, United States
Hematology Oncology Associates of Fredericksburg Inc
RECRUITING

Fredericksburg, Virginia, 22408, United States
Hurley Medical Center
RECRUITING

Flint, Michigan, 48503, United States
Illinois CancerCare - Washington
RECRUITING

Washington, Illinois, 61571, United States
Illinois CancerCare-Bloomington
RECRUITING

Bloomington, Illinois, 61704, United States
Illinois CancerCare-Canton
RECRUITING

Canton, Illinois, 61520, United States
Illinois CancerCare-Carthage
RECRUITING

Carthage, Illinois, 62321, United States
Illinois CancerCare-Dixon
RECRUITING

Dixon, Illinois, 61021, United States
Illinois CancerCare-Eureka
RECRUITING

Eureka, Illinois, 61530, United States
Illinois CancerCare-Galesburg
RECRUITING

Galesburg, Illinois, 61401, United States
Illinois CancerCare-Kewanee Clinic
RECRUITING

Kewanee, Illinois, 61443, United States
Illinois CancerCare-Macomb
RECRUITING

Macomb, Illinois, 61455, United States
Illinois CancerCare-Ottawa Clinic
RECRUITING

Ottawa, Illinois, 61350, United States
Illinois CancerCare-Pekin
RECRUITING

Pekin, Illinois, 61554, United States
Illinois CancerCare-Peoria
RECRUITING

Peoria, Illinois, 61615, United States
Illinois CancerCare-Peru
RECRUITING

Peru, Illinois, 61354, United States
Illinois CancerCare-Princeton
RECRUITING

Princeton, Illinois, 61356, United States
Intermountain Medical Center
RECRUITING

Murray, Utah, 84107, United States

Contact Email: •••••@•••••
Jefferson Cherry Hill Hospital
RECRUITING

Cherry Hill, New Jersey, 08002, United States

Contact Email: •••••@•••••
Jefferson Hospital
RECRUITING

Jefferson Hills, Pennsylvania, 15025, United States
Jefferson Methodist Hospital
SUSPENDED

Philadelphia, Pennsylvania, 19148, United States
Jefferson Torresdale Hospital
RECRUITING

Philadelphia, Pennsylvania, 19114, United States

Contact Email: •••••@•••••
Kaiser Permanente Downtown Commons
RECRUITING

Sacramento, California, 95814, United States
Kaiser Permanente Dublin
RECRUITING

Dublin, California, 94568, United States
Kaiser Permanente Fresno Orchard Plaza
RECRUITING

Fresno, California, 93720, United States
Kaiser Permanente Medical Center - Santa Clara
RECRUITING

Santa Clara, California, 95051, United States
Kaiser Permanente Moanalua Medical Center
RECRUITING

Honolulu, Hawaii, 96819, United States
Kaiser Permanente San Leandro
RECRUITING

San Leandro, California, 94577, United States
Kaiser Permanente- Modesto MOB II
RECRUITING

Modesto, California, 95356, United States
Kaiser Permanente-Franklin
RECRUITING

Denver, Colorado, 80205, United States

Contact Email: •••••@•••••
Kaiser Permanente-Fremont
RECRUITING

Fremont, California, 94538, United States
Kaiser Permanente-Lone Tree
RECRUITING

Lone Tree, Colorado, 80124, United States

Contact Email: •••••@•••••
Kaiser Permanente-Modesto
RECRUITING

Modesto, California, 95356, United States
Kaiser Permanente-Oakland
RECRUITING

Oakland, California, 94611, United States
Kaiser Permanente-Rock Creek
RECRUITING

Lafayette, Colorado, 80026, United States

Contact Email: •••••@•••••
Kaiser Permanente-Roseville
RECRUITING

Roseville, California, 95661, United States
Kaiser Permanente-San Francisco
RECRUITING

San Francisco, California, 94115, United States
Kaiser Permanente-Santa Rosa
RECRUITING

Santa Rosa, California, 95403, United States
Kaiser Permanente-Santa Teresa-San Jose
RECRUITING

San Jose, California, 95119, United States
Kaiser Permanente-South Sacramento
RECRUITING

Sacramento, California, 95823, United States
Kaiser Permanente-South San Francisco
RECRUITING

South San Francisco, California, 94080, United States
Kaiser Permanente-Vallejo
RECRUITING

Vallejo, California, 94589, United States
Kaiser Permanente-Walnut Creek
RECRUITING

Walnut Creek, California, 94596, United States
Kaiser San Rafael-Gallinas
RECRUITING

San Rafael, California, 94903, United States
Kootenai Clinic Cancer Services - Post Falls
RECRUITING

Post Falls, Idaho, 83854, United States

Contact Email: •••••@•••••
Kootenai Clinic Cancer Services - Sandpoint
RECRUITING

Sandpoint, Idaho, 83864, United States

Contact Email: •••••@•••••
Kootenai Health - Coeur d'Alene
RECRUITING

Coeur d'Alene, Idaho, 83814, United States

Contact Email: •••••@•••••
LDS Hospital
RECRUITING

Salt Lake City, Utah, 84143, United States

Contact Email: •••••@•••••
Lawrence Memorial Hospital
RECRUITING

Lawrence, Kansas, 66044, United States
Logan Health Medical Center
RECRUITING

Kalispell, Montana, 59901, United States

Contact Email: •••••@•••••
Malcom Randall Veterans Administration Medical Center
RECRUITING

Gainesville, Florida, 32610, United States

Contact Email: •••••@•••••
Mary Greeley Medical Center
RECRUITING

Ames, Iowa, 50010, United States
McFarland Clinic - Ames
RECRUITING

Ames, Iowa, 50010, United States
McFarland Clinic - Boone
SUSPENDED

Boone, Iowa, 50036, United States
McFarland Clinic - Jefferson
SUSPENDED

Jefferson, Iowa, 50129, United States
McFarland Clinic - Marshalltown
RECRUITING

Marshalltown, Iowa, 50158, United States
McFarland Clinic - Trinity Cancer Center
RECRUITING

Fort Dodge, Iowa, 50501, United States
MedStar Georgetown University Hospital
RECRUITING

Washington D.C., District of Columbia, 20007, United States
MedStar Washington Hospital Center
RECRUITING

Washington D.C., District of Columbia, 20010, United States
Medical College of Wisconsin
RECRUITING

Milwaukee, Wisconsin, 53226, United States
Memorial Hospital East
RECRUITING

Shiloh, Illinois, 62269, United States
Memorial Sloan Kettering Basking Ridge
RECRUITING

Basking Ridge, New Jersey, 07920, United States
Memorial Sloan Kettering Bergen
RECRUITING

Montvale, New Jersey, 07645, United States
Memorial Sloan Kettering Cancer Center
RECRUITING

New York, New York, 10065, United States
Memorial Sloan Kettering Commack
RECRUITING

Commack, New York, 11725, United States
Memorial Sloan Kettering Monmouth
RECRUITING

Middletown, New Jersey, 07748, United States
Memorial Sloan Kettering Nassau
RECRUITING

Uniondale, New York, 11553, United States
Memorial Sloan Kettering Westchester
RECRUITING

Harrison, New York, 10604, United States
Mercy Hospital
RECRUITING

Cedar Rapids, Iowa, 52403, United States
Mercy Hospital Saint Louis
RECRUITING

St Louis, Missouri, 63141, United States
Mercy Hospital South
RECRUITING

St Louis, Missouri, 63128, United States
Mount Sinai Hospital
RECRUITING

New York, New York, 10029, United States
Northside Hospital
RECRUITING

Atlanta, Georgia, 30342, United States

Contact Email: •••••@•••••
Northside Hospital - Duluth
RECRUITING

Duluth, Georgia, 30096, United States

Contact Email: •••••@•••••
Northside Hospital - Gwinnett
RECRUITING

Lawrenceville, Georgia, 30046, United States

Contact Email: •••••@•••••
OSF Saint Francis Hospital and Medical Group
RECRUITING

Escanaba, Michigan, 49829, United States
Ohio State University Comprehensive Cancer Center
RECRUITING

Columbus, Ohio, 43210, United States
Oncology Associates at Mercy Medical Center
RECRUITING

Cedar Rapids, Iowa, 52403, United States
ProMedica Flower Hospital
RECRUITING

Sylvania, Ohio, 43560, United States

Contact Email: •••••@•••••
Rapid City Regional Hospital
RECRUITING

Rapid City, South Dakota, 57701, United States

Contact Email: •••••@•••••
Reiman Cancer Center-Ascension Wisconsin Health Center-Rawson
RECRUITING

Franklin, Wisconsin, 53132, United States
Roswell Park Cancer Institute
RECRUITING

Buffalo, New York, 14263, United States
Rush MD Anderson Cancer Center
RECRUITING

Chicago, Illinois, 60612, United States

Contact Email: •••••@•••••
SSM Health Good Samaritan
RECRUITING

Mount Vernon, Illinois, 62864, United States
Saint Francis Cancer Center
RECRUITING

Greenville, South Carolina, 29607, United States
Saint Francis Hospital
RECRUITING

Greenville, South Carolina, 29601, United States
Saint Francis Medical Center
RECRUITING

Cape Girardeau, Missouri, 63703, United States
Saint George Regional Medical Center
RECRUITING

St. George, Utah, 84770, United States

Contact Email: •••••@•••••
Saint Luke's Cancer Institute - Boise
RECRUITING

Boise, Idaho, 83712, United States
Saint Luke's Cancer Institute - Fruitland
RECRUITING

Fruitland, Idaho, 83619, United States
Saint Luke's Cancer Institute - Meridian
RECRUITING

Meridian, Idaho, 83642, United States
Saint Luke's Cancer Institute - Nampa
RECRUITING

Nampa, Idaho, 83687, United States
Saint Mary's Hospital and Regional Medical Center
RECRUITING

Grand Junction, Colorado, 81501, United States
Saint Vincent Frontier Cancer Center
RECRUITING

Billings, Montana, 59102, United States
Saint Vincent Hospital
RECRUITING

Erie, Pennsylvania, 16544, United States
Saint Vincent Hospital Cancer Center Green Bay
RECRUITING

Green Bay, Wisconsin, 54301, United States
Saint Vincent Hospital Cancer Center at Oconto Falls
RECRUITING

Oconto Falls, Wisconsin, 54154, United States
Saint Vincent Hospital Cancer Center at Saint Mary's
RECRUITING

Green Bay, Wisconsin, 54303, United States
Saint Vincent Hospital Cancer Center at Sheboygan
RECRUITING

Sheboygan, Wisconsin, 53081, United States
Saint Vincent Hospital Cancer Center at Sturgeon Bay
RECRUITING

Sturgeon Bay, Wisconsin, 54235-1495, United States
Salina Regional Health Center
RECRUITING

Salina, Kansas, 67401, United States
Sanford Bismarck Medical Center
RECRUITING

Bismarck, North Dakota, 58501, United States

Contact Email: •••••@•••••
Sanford Broadway Medical Center
RECRUITING

Fargo, North Dakota, 58122, United States

Contact Email: •••••@•••••
Sanford Cancer Center Oncology Clinic
RECRUITING

Sioux Falls, South Dakota, 57104, United States

Contact Email: •••••@•••••
Sanford Joe Lueken Cancer Center
RECRUITING

Bemidji, Minnesota, 56601, United States

Contact Email: •••••@•••••
Sanford Roger Maris Cancer Center
RECRUITING

Fargo, North Dakota, 58122, United States

Contact Email: •••••@•••••
Sanford USD Medical Center - Sioux Falls
RECRUITING

Sioux Falls, South Dakota, 57117-5134, United States

Contact Email: •••••@•••••
Self Regional Healthcare
RECRUITING

Greenwood, South Carolina, 29646, United States
Shaw Cancer Center
RECRUITING

Edwards, Colorado, 81632, United States
Sheboygan Physicians Group
RECRUITING

Sheboygan, Wisconsin, 53081, United States
Sidney Kimmel Cancer Center Washington Township
RECRUITING

Sewell, New Jersey, 08080, United States

Contact Email: •••••@•••••
Siteman Cancer Center at Christian Hospital
RECRUITING

St Louis, Missouri, 63136, United States

Contact Email: •••••@•••••
Siteman Cancer Center at Saint Peters Hospital
RECRUITING

City of Saint Peters, Missouri, 63376, United States

Contact Email: •••••@•••••
Siteman Cancer Center at West County Hospital
RECRUITING

Creve Coeur, Missouri, 63141, United States

Contact Email: •••••@•••••
Siteman Cancer Center-South County
RECRUITING

St Louis, Missouri, 63129, United States

Contact Email: •••••@•••••
Southern Illinois University School of Medicine
RECRUITING

Springfield, Illinois, 62702, United States
Springfield Clinic
RECRUITING

Springfield, Illinois, 62702, United States
Springfield Memorial Hospital
RECRUITING

Springfield, Illinois, 62781, United States
Stony Brook University Medical Center
RECRUITING

Stony Brook, New York, 11794, United States
The University of Kansas Cancer Center - Olathe
RECRUITING

Olathe, Kansas, 66061, United States

Contact Email: •••••@•••••
ThedaCare Regional Cancer Center
RECRUITING

Appleton, Wisconsin, 54911, United States

Contact Email: •••••@•••••
Thomas Jefferson University Hospital
RECRUITING

Philadelphia, Pennsylvania, 19107, United States

Contact Email: •••••@•••••
Trinity Health IHA Medical Group Hematology Oncology - Brighton
RECRUITING

Brighton, Michigan, 48114, United States
Trinity Health IHA Medical Group Hematology Oncology - Canton
RECRUITING

Canton, Michigan, 48188, United States
Trinity Health IHA Medical Group Hematology Oncology - Chelsea Hospital
RECRUITING

Chelsea, Michigan, 48118, United States
Trinity Health IHA Medical Group Hematology Oncology Ann Arbor Campus
RECRUITING

Ypsilanti, Michigan, 48197, United States
Trinity Health Saint Joseph Mercy Oakland Hospital
RECRUITING

Pontiac, Michigan, 48341, United States
Trinity Health Saint Mary Mercy Livonia Hospital
RECRUITING

Livonia, Michigan, 48154, United States
UC San Diego Medical Center - Hillcrest
RECRUITING

San Diego, California, 92103, United States
UC San Diego Moores Cancer Center
RECRUITING

La Jolla, California, 92093, United States

Contact Email: •••••@•••••
UT Southwestern Clinical Center at Richardson/Plano
RECRUITING

Richardson, Texas, 75080, United States
UT Southwestern Simmons Cancer Center - RedBird
RECRUITING

Dallas, Texas, 75237, United States

Contact Email: •••••@•••••
UT Southwestern/Simmons Cancer Center-Dallas
RECRUITING

Dallas, Texas, 75390, United States

Contact Email: •••••@•••••
UT Southwestern/Simmons Cancer Center-Fort Worth
RECRUITING

Fort Worth, Texas, 76104, United States

Contact Email: •••••@•••••
University Health Truman Medical Center
RECRUITING

Kansas City, Missouri, 64108, United States
University of Arizona Cancer Center-North Campus
RECRUITING

Tucson, Arizona, 85719, United States
University of Illinois
RECRUITING

Chicago, Illinois, 60612, United States
University of Kansas Cancer Center - Briarcliff
RECRUITING

Kansas City, Missouri, 64116, United States
University of Kansas Cancer Center - Lee's Summit
RECRUITING

Lee's Summit, Missouri, 64064, United States
University of Kansas Cancer Center - North
RECRUITING

Kansas City, Missouri, 64154, United States
University of Kansas Cancer Center-Overland Park
RECRUITING

Overland Park, Kansas, 66210, United States
University of Kansas Health System Saint Francis Campus
RECRUITING

Topeka, Kansas, 66606, United States
University of Kansas Hospital-Westwood Cancer Center
RECRUITING

Westwood, Kansas, 66205, United States
University of Michigan Health - Sparrow Lansing
RECRUITING

Lansing, Michigan, 48912, United States
University of Oklahoma Health Sciences Center
RECRUITING

Oklahoma City, Oklahoma, 73104, United States
University of Vermont Medical Center
RECRUITING

Burlington, Vermont, 05401, United States
University of Vermont and State Agricultural College
RECRUITING

Burlington, Vermont, 05405, United States
VCU Health Tappahannock Hospital
RECRUITING

Tappahannock, Virginia, 22560, United States
VCU Massey Cancer Center at Stony Point
RECRUITING

Richmond, Virginia, 23235, United States
VCU Massey Comprehensive Cancer Center
RECRUITING

Richmond, Virginia, 23298, United States
Washington University School of Medicine
RECRUITING

St Louis, Missouri, 63110, United States

Contact Email: •••••@•••••
West Penn Hospital
RECRUITING

Pittsburgh, Pennsylvania, 15224, United States
West Virginia University Charleston Division
RECRUITING

Charleston, West Virginia, 25304, United States
Wexford Health and Wellness Pavilion
RECRUITING

Wexford, Pennsylvania, 15090, United States
William S Middleton VA Medical Center
RECRUITING

Madison, Wisconsin, 53705, United States

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