Targeted radiation after lung cancer surgery aims to stop return

NCT ID NCT07293247

Recruiting now Disease control Sponsor: Alliance for Clinical Trials in Oncology Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Aug 06, 2026 · Updated 3 times

Summary

This study tests whether adding a precise type of radiation therapy (I²-PORT) after lung cancer surgery can help prevent the cancer from coming back. Participants have non-small cell lung cancer with remaining cancer in lymph nodes after initial treatment. The trial compares standard care (chemotherapy or immunotherapy) alone versus standard care plus the targeted radiation. About 164 people will take part.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Intensity-modulated radiation therapy (IMRT)
What this could lead to: If successful, this approach could lower the chance of lung cancer returning after surgery and improve long-term survival.
What could go wrong: This is a phase 2 trial with 164 participants, so results are still preliminary. The added radiation may cause side effects like lung or heart problems.

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Conditions

The condition(s) this trial relates to.

non-small cell lung carcinoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

LUNG NON-SMALL CELL CARCINOMA

Contacts and locations

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Locations

Baptist Memorial Hospital and Cancer Center-Collierville
RECRUITING

Collierville, Tennessee, 38017, United States

Contact Email: •••••@•••••
Baptist Memorial Hospital and Cancer Center-Desoto
RECRUITING

Southhaven, Mississippi, 38671, United States

Contact Email: •••••@•••••
Baptist Memorial Hospital and Cancer Center-Memphis
RECRUITING

Memphis, Tennessee, 38120, United States

Contact Email: •••••@•••••
Cancer Care Center of O'Fallon
RECRUITING

O'Fallon, Illinois, 62269, United States
Cancer Care Specialists of Illinois - Decatur
RECRUITING

Decatur, Illinois, 62526, United States
Chelsea Hospital
RECRUITING

Chelsea, Michigan, 48118, United States
Decatur Memorial Hospital
RECRUITING

Decatur, Illinois, 62526, United States
Duluth Clinic Ashland
RECRUITING

Ashland, Wisconsin, 54806, United States

Contact Email: •••••@•••••
Essentia Health - Deer River Clinic
RECRUITING

Deer River, Minnesota, 56636, United States

Contact Email: •••••@•••••
Essentia Health Cancer Center
RECRUITING

Duluth, Minnesota, 55805, United States

Contact Email: •••••@•••••
Essentia Health Hibbing Clinic
RECRUITING

Hibbing, Minnesota, 55746, United States
Essentia Health Saint Joseph's Medical Center
RECRUITING

Brainerd, Minnesota, 56401, United States

Contact Email: •••••@•••••
Essentia Health Saint Mary's Hospital - Superior
RECRUITING

Superior, Wisconsin, 54880, United States
Essentia Health Saint Mary's Medical Center
RECRUITING

Duluth, Minnesota, 55805, United States

Contact Email: •••••@•••••
Essentia Health Sandstone
RECRUITING

Sandstone, Minnesota, 55072, United States

Contact Email: •••••@•••••
Essentia Health Virginia Clinic
RECRUITING

Virginia, Minnesota, 55792, United States

Contact Email: •••••@•••••
Essentia Health-Hayward Clinic
RECRUITING

Hayward, Wisconsin, 54843, United States

Contact Email: •••••@•••••
Essentia Health-Spooner Clinic
RECRUITING

Spooner, Wisconsin, 54801, United States

Contact Email: •••••@•••••
HSHS Saint Elizabeth's Hospital
RECRUITING

O'Fallon, Illinois, 62269, United States
Illinois CancerCare - Washington
RECRUITING

Washington, Illinois, 61571, United States
Illinois CancerCare-Bloomington
RECRUITING

Bloomington, Illinois, 61704, United States
Illinois CancerCare-Canton
RECRUITING

Canton, Illinois, 61520, United States
Illinois CancerCare-Carthage
RECRUITING

Carthage, Illinois, 62321, United States
Illinois CancerCare-Eureka
RECRUITING

Eureka, Illinois, 61530, United States
Illinois CancerCare-Galesburg
RECRUITING

Galesburg, Illinois, 61401, United States
Illinois CancerCare-Kewanee Clinic
RECRUITING

Kewanee, Illinois, 61443, United States
Illinois CancerCare-Macomb
RECRUITING

Macomb, Illinois, 61455, United States
Illinois CancerCare-Ottawa Clinic
RECRUITING

Ottawa, Illinois, 61350, United States
Illinois CancerCare-Pekin
RECRUITING

Pekin, Illinois, 61554, United States
Illinois CancerCare-Peoria
RECRUITING

Peoria, Illinois, 61615, United States
Illinois CancerCare-Peru
RECRUITING

Peru, Illinois, 61354, United States
Illinois CancerCare-Princeton
RECRUITING

Princeton, Illinois, 61356, United States
MaineHealth Cancer Care Center of York County
RECRUITING

Sanford, Maine, 04073, United States
MaineHealth Cancer Care and IV Therapy - Brunswick
RECRUITING

Brunswick, Maine, 04011, United States

Contact Email: •••••@•••••
MaineHealth Cancer Care and IV Therapy - South Portland
RECRUITING

South Portland, Maine, 04106, United States

Contact Email: •••••@•••••
MaineHealth Coastal Cancer Treatment Center
RECRUITING

Bath, Maine, 04530, United States
MaineHealth Maine Medical Center - Portland
RECRUITING

Portland, Maine, 04102, United States

Contact Email: •••••@•••••
MaineHealth Maine Medical Center- Scarborough
RECRUITING

Scarborough, Maine, 04074, United States

Contact Email: •••••@•••••
Memorial Sloan Kettering Basking Ridge
RECRUITING

Basking Ridge, New Jersey, 07920, United States
Memorial Sloan Kettering Bergen
RECRUITING

Montvale, New Jersey, 07645, United States
Memorial Sloan Kettering Cancer Center
RECRUITING

New York, New York, 10065, United States
Memorial Sloan Kettering Commack
RECRUITING

Commack, New York, 11725, United States
Memorial Sloan Kettering Monmouth
RECRUITING

Middletown, New Jersey, 07748, United States
Memorial Sloan Kettering Nassau
RECRUITING

Uniondale, New York, 11553, United States
Memorial Sloan Kettering Westchester
RECRUITING

Harrison, New York, 10604, United States
Miller-Dwan Hospital
RECRUITING

Duluth, Minnesota, 55805, United States

Contact Email: •••••@•••••
Montefiore Medical Center - Moses Campus
RECRUITING

The Bronx, New York, 10467, United States
Montefiore Medical Center-Einstein Campus
RECRUITING

The Bronx, New York, 10461, United States
NEA Baptist Memorial Hospital and Fowler Family Cancer Center - Jonesboro
RECRUITING

Jonesboro, Arkansas, 72401, United States
New York Proton Center
RECRUITING

New York, New York, 10035, United States
Northwest Wisconsin Cancer Center
RECRUITING

Ashland, Wisconsin, 54806, United States

Contact Email: •••••@•••••
OSF Saint Francis Medical Center
RECRUITING

Peoria, Illinois, 61637, United States
OSF Saint Francis Radiation Oncology at Pekin
RECRUITING

Pekin, Illinois, 61554, United States
OSF Saint Francis Radiation Oncology at Peoria Cancer Center
RECRUITING

Peoria, Illinois, 61615, United States
OSF Saint Joseph Medical Center
RECRUITING

Bloomington, Illinois, 61701, United States
Ohio State University Comprehensive Cancer Center
RECRUITING

Columbus, Ohio, 43210, United States
Rush MD Anderson Cancer Center
RECRUITING

Chicago, Illinois, 60612, United States

Contact Email: •••••@•••••
Saint Francis Medical Center
RECRUITING

Cape Girardeau, Missouri, 63703, United States
Sanford Bismarck Medical Center
RECRUITING

Bismarck, North Dakota, 58501, United States

Contact Email: •••••@•••••
Sanford Broadway Medical Center
RECRUITING

Fargo, North Dakota, 58122, United States

Contact Email: •••••@•••••
Sanford Cancer Center Oncology Clinic
RECRUITING

Sioux Falls, South Dakota, 57104, United States

Contact Email: •••••@•••••
Sanford Joe Lueken Cancer Center
RECRUITING

Bemidji, Minnesota, 56601, United States

Contact Email: •••••@•••••
Sanford Roger Maris Cancer Center
RECRUITING

Fargo, North Dakota, 58122, United States

Contact Email: •••••@•••••
Sanford USD Medical Center - Sioux Falls
RECRUITING

Sioux Falls, South Dakota, 57117-5134, United States

Contact Email: •••••@•••••
Trinity Health IHA Medical Group Hematology Oncology - Brighton
RECRUITING

Brighton, Michigan, 48114, United States
Trinity Health IHA Medical Group Hematology Oncology - Canton
RECRUITING

Canton, Michigan, 48188, United States
Trinity Health IHA Medical Group Hematology Oncology - Chelsea Hospital
RECRUITING

Chelsea, Michigan, 48118, United States
Trinity Health IHA Medical Group Hematology Oncology Ann Arbor Campus
RECRUITING

Ypsilanti, Michigan, 48197, United States
Trinity Health Medical Center - Brighton
RECRUITING

Brighton, Michigan, 48114, United States
Trinity Health Medical Center - Canton
RECRUITING

Canton, Michigan, 48188, United States
Trinity Health Saint Joseph Mercy Hospital Ann Arbor
RECRUITING

Ann Arbor, Michigan, 48106, United States
Trinity Health Saint Mary Mercy Livonia Hospital
RECRUITING

Livonia, Michigan, 48154, United States
UNC Lineberger Comprehensive Cancer Center
RECRUITING

Chapel Hill, North Carolina, 27599, United States

Contact Email: •••••@•••••
USC / Norris Comprehensive Cancer Center
RECRUITING

Los Angeles, California, 90033, United States

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