LUNG NON-SMALL CELL CARCINOMA

This phase 3 trial tests whether adding the immunotherapy drug pembrolizumab to standard chemotherapy after surgery can help prevent non-small cell lung cancer from coming back. About 1,210 people with stage II to IIIB lung cancer will receive either chemo plus pembrolizumab toge…

This phase 3 trial is testing whether the immunotherapy drug durvalumab, given after surgery, can prevent early-stage non-small cell lung cancer from coming back. About 306 participants who have had their tumor completely removed will be randomly assigned to receive durvalumab or…

This phase III trial is testing whether the immunotherapy drug atezolizumab, given after surgery, can prevent stage I non-small cell lung cancer from returning. About 336 patients who have had their tumor completely removed will be randomly assigned to receive either atezolizumab…

This early-stage trial tests gilteritinib, a drug already approved for leukemia, in 30 people with stage IV ALK-positive non-small cell lung cancer that has stopped responding to other treatments. The main goal is to find the safest dose and check for side effects. Researchers ho…

This study tests whether adding a precise type of radiation therapy (I²-PORT) after lung cancer surgery can help prevent the cancer from coming back. Participants have non-small cell lung cancer with remaining cancer in lymph nodes after initial treatment. The trial compares stan…

This study is testing whether artificial intelligence (AI) can help doctors choose the right radiation dose for people with lung cancer or tumors that have spread to the lung. The treatment uses a precise type of radiation called SBRT, and the AI aims to personalize the dose to e…

This phase II trial tests whether adding two types of precisely targeted radiation (BgRT and SBRT) to the standard drug osimertinib can better control advanced EGFR-positive lung cancer that has started to grow in a few new spots. About 32 adults with this specific type of lung c…

This study tests a drug called amivantamab, given as a shot under the skin, for people with advanced non-small cell lung cancer that has extra copies of the MET gene. The goal is to see if the drug can shrink tumors or stop them from growing. About 88 participants will take part …

This study tests a combination of two drugs, telisotuzumab vedotin and osimertinib, in people with a type of advanced lung cancer (NSCLC) that has stopped responding to osimertinib alone. The cancer must have a specific gene change (EGFR mutation) and high levels of a protein cal…

This phase II trial at Mayo Clinic is testing a special type of radiation called grid therapy combined with standard immunotherapy for people with stage IV non-small cell lung cancer that has stopped responding to treatment. Grid therapy delivers high doses of radiation to small …

This study tests a procedure called chemoembolization for people with non-small cell lung cancer or lung tumors that have spread from other cancers. Doctors inject chemotherapy directly into the artery feeding the tumor and then block that artery with tiny beads. This traps the c…

This phase II trial is testing whether giving a combination of two immunotherapy drugs (cemiplimab and fianlimab) before surgery can kill more tumor cells in people with stage IB to IIIB non-small cell lung cancer. About 60 participants will receive the drugs intravenously, then …

This early-phase trial tests whether adding low-dose interleukin-2 (IL-2) to the immunotherapy drug pembrolizumab (Keytruda) can better activate the immune system against stage IV non-small cell lung cancer. The study will enroll 15 people who have not had prior treatment for the…

This study tests a new way to deliver radiation therapy for people with lung cancer, melanoma, or kidney cancer that has started to grow again in a few spots despite treatment. The approach uses a PET scan to find the most active parts of the tumor and delivers a higher radiation…

This study tests whether a home-based aerobic exercise program can help lung cancer patients respond better to immunotherapy. Researchers will measure changes in immune cells and inflammation markers in 100 participants. The goal is to see if exercise can improve treatment effect…

This study compares giving the cancer drug nivolumab (Opdivo) as a shot at home versus in a clinic for people with various advanced cancers. The goal is to see if home treatment improves patients' overall care experience and quality of life. About 50 adults will receive the drug …

This study is testing whether psilocybin (the active ingredient in magic mushrooms) combined with therapy is safe and helpful for people with non-small cell lung cancer who also have major depression. Ten participants will receive psilocybin in a controlled setting along with cou…

This study tests whether a yoga program designed for both patients and their family caregivers can improve physical function, fatigue, sleep, mood, and quality of life. It includes 400 people with lung or esophageal cancer who are getting radiation therapy, plus their caregivers.…

This study looks at blood and tissue samples from people with advanced non-small cell lung cancer to find markers that predict how well immunotherapy works. The goal is to use these markers to choose the best second-line treatment if the first one stops working. About 535 partici…

This study interviews 45 adults with non-small cell lung cancer who also had a past alcohol or substance use disorder (other than tobacco). Researchers want to learn what social factors help or hinder detection and treatment of their cancer. The goal is to identify ways to improv…

This study follows 2,000 adults with newly diagnosed breast, colorectal, lung, melanoma, or lymphoma cancer who are receiving chemotherapy or immunotherapy. Researchers will track whether using cannabis or cannabinoids helps with symptoms like pain or nausea over time. No treatme…

This study surveys 40 adults with non-small cell lung cancer who are already receiving immunotherapy drugs like Keytruda or Opdivo. Researchers want to know how satisfied patients are with IV infusions at the hospital versus the idea of getting shots at home. The goal is to under…

This study looks at how the bacteria in your gut might cause stomach issues like diarrhea and colitis when you take certain cancer drugs called immune checkpoint inhibitors. Researchers will collect stool, blood, and tissue samples from 800 people with melanoma, lung cancer, or g…

This study tests a communication tool that helps doctors and patients with non-small cell lung cancer work together on treatment decisions. About 100 patients and their doctors will use the tool during appointments to see if it improves how decisions are made and how satisfied pa…

This study tracks 150 people with non-small cell lung cancer who are getting chemotherapy and radiation followed by immunotherapy. Researchers collect blood, saliva, stool, and lung fluid samples, along with regular lung function tests, to find early signs of lung inflammation (p…

This trial compares two standard surgical techniques for early-stage lung cancer: tying off the pulmonary vein first versus the pulmonary artery first. Researchers want to see which method better reduces circulating tumor DNA (ctDNA) in the blood after surgery, as lower ctDNA may…

This study looks at whether giving early-stage lung cancer patients detailed information about quality of life outcomes helps them feel more satisfied with their choice between surgery and radiation therapy. About 150 patients will be enrolled, and researchers will measure decisi…