Lung cancer surgery showdown: which technique stops tumor DNA spread?

NCT ID NCT05502523

Recruiting now Knowledge-focused Sponsor: Thomas Jefferson University Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This trial compares two standard surgical techniques for early-stage lung cancer: tying off the pulmonary vein first versus the pulmonary artery first. Researchers want to see which method better reduces circulating tumor DNA (ctDNA) in the blood after surgery, as lower ctDNA may mean fewer cancer cells spreading. About 100 patients with stage I-III non-small cell lung cancer will participate, with blood samples taken before and after surgery to measure ctDNA levels.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Pulmonary artery-first surgical technique
What this could lead to: If this trial succeeds, it could show that one surgical method reduces tumor cell spread better than the other, potentially guiding future lung cancer surgeries.
What could go wrong: This is an early-stage study with only 100 participants, so results may not apply to all patients. The main focus is on a biomarker (ctDNA), not direct survival benefits.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Get updates

Get notified about this study

Sign up to get updates when this study changes or when new studies for LUNG NON-SMALL CELL CARCINOMA are added.

Our safety recommendation!

By submitting, you agree to our Terms of use

Conditions

The condition(s) this trial relates to.

lung cancer lung neoplasm non-small cell lung carcinoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

LUNG NON-SMALL CELL CARCINOMA STAGE I LUNG CANCER AJCC V8 STAGE II LUNG CANCER AJCC V8 STAGE III LUNG CANCER AJCC V8

Contacts and locations

Locations

Abington Memorial Hospital
RECRUITING

Abington, Pennsylvania, 19001, United States
Asplundh Cancer Pavilion at Jefferson Health
RECRUITING

Willow Grove, Pennsylvania, 19090, United States
Jefferson Health Northeast
RECRUITING

Philadelphia, Pennsylvania, 19107, United States
Thomas Jefferson University Hospital
RECRUITING

Philadelphia, Pennsylvania, 19107, United States

More trials for these conditions

Other studies related to the condition(s) this trial covers.