Lung cancer surgery showdown: which technique stops tumor DNA spread?
NCT ID NCT05502523
First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This trial compares two standard surgical techniques for early-stage lung cancer: tying off the pulmonary vein first versus the pulmonary artery first. Researchers want to see which method better reduces circulating tumor DNA (ctDNA) in the blood after surgery, as lower ctDNA may mean fewer cancer cells spreading. About 100 patients with stage I-III non-small cell lung cancer will participate, with blood samples taken before and after surgery to measure ctDNA levels.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
Pulmonary artery-first surgical technique
What this could lead to
If this trial succeeds, it could show that one surgical method reduces tumor cell spread better than the other, potentially guiding future lung cancer surgeries.
What could go wrong
This is an early-stage study with only 100 participants, so results may not apply to all patients. The main focus is on a biomarker (ctDNA), not direct survival benefits.
Disclaimer
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the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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Abington Memorial Hospital
RECRUITINGAbington, Pennsylvania, 19001, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Asplundh Cancer Pavilion at Jefferson Health
RECRUITINGWillow Grove, Pennsylvania, 19090, United States
Contact Phone: •••-•••-••••
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Jefferson Health Northeast
RECRUITINGPhiladelphia, Pennsylvania, 19107, United States
Contact Phone: •••-•••-••••
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Thomas Jefferson University Hospital
RECRUITINGPhiladelphia, Pennsylvania, 19107, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••