Thomas Jefferson University

This study is testing a modified, gentler two-step method to prepare patients for a stem cell transplant. The goal is to reduce the risk of death from the transplant procedure itself for people with various blood cancers and disorders. Researchers are comparing two lower-intensit…

This study is comparing two standard surgical methods for bladder cancer. It will see if patients do better with or without a temporary plastic tube (a ureteral stent) placed during surgery to remove the bladder. Researchers will track 70 patients for a year to measure complicati…

This early-stage study is testing whether using ultrasound waves on a tumor can help a standard cancer drug (pembrolizumab) work better. It involves 6 patients with advanced head and neck cancer that has returned or spread. The main goal is to see if combining the drug with this …

This study is testing if reducing calorie intake by 25% while receiving a highly focused, intense form of radiation before surgery helps shrink breast tumors more than radiation alone. It will involve 80 women with early-stage breast cancer. The goal is to see if this combined ap…

This early-stage study is testing two new drug combinations for adults whose acute myeloid leukemia (AML) has returned or not responded to prior treatment. The first part combines tazemetostat with a standard chemotherapy drug (CPX-351). The second part tests a drug called palboc…

This early-stage study is testing the safety and best dose of an oral drug called VK-2019 for adults with a specific type of aggressive lymphoma linked to the Epstein-Barr virus (EBV). The lymphoma must have returned or not responded to at least two prior treatments. Participants…

This study is testing whether using virtual reality (VR) to create a 3D map of a patient's tumor before surgery helps surgeons operate more precisely. The goal is to remove all the cancer while sparing healthy tissue, which could lead to fewer repeat procedures and better long-te…

This study is testing if adding cognitive behavioral therapy (CBT) to standard education helps people who regularly take opioids successfully reduce their dose before spine surgery. Researchers will enroll 45 adults and randomly assign them to receive either education alone or ed…

This study is testing whether combining a newer immunotherapy drug (tebentafusp-tebn) with treatments that target the liver directly can better control metastatic uveal melanoma. It will enroll about 109 patients whose eye cancer has spread to the liver. The trial has two parts: …

This study is testing if a wearable continuous glucose monitor (CGM) is easier for pregnant women with type 2 diabetes to use than the standard finger-prick method. It will see if patients are better at tracking their blood sugar with the CGM, which could lead to better health fo…

This study is testing whether giving one or two immunotherapy drugs before surgery can shrink advanced basal cell carcinomas on the head and neck. The goal is to see if shrinking the tumor first allows surgeons to perform a less extensive operation, potentially preserving importa…

This study is testing whether getting iron through an IV is better than taking iron pills for pregnant women with low iron. Researchers want to see which method improves blood counts more effectively, causes fewer side effects, and leads to a better quality of life. About 80 wome…

This study is testing a new approach to collecting a patient's own stem cells for a transplant to treat blood cancers like multiple myeloma and lymphoma. The goal is to see if using a standard drug (G-CSF) first and only adding a second drug (Plerixafor) if needed can successfull…

This study is testing whether a drug called tebentafusp can shrink large, inoperable eye melanoma tumors before patients receive standard surgery or radiation. The drug works by guiding the body's immune cells to attack the cancer. The main goal is to see if shrinking the tumor f…

This study is testing a new, non-surgical approach to help people with long-term spinal cord injuries breathe better. Researchers are combining gentle electrical stimulation on the back with special breathing exercises that use low-oxygen air. The goal is to 'wake up' the nerves …

This study is testing if a special type of ultrasound, called contrast-enhanced ultrasound (CEUS), can better check if a liver cancer treatment is working. It will compare CEUS to the standard CT or MRI scans that patients already get. The goal is to see if CEUS can give doctors …

This study is testing a new urine test designed to detect prostate cancer cells. Researchers will analyze urine samples from about 675 men, including those with and without cancer, to see if the test can accurately identify the disease. The goal is to develop a less invasive way …

This study is testing whether two different at-home HPV self-collection kits are a good alternative to a doctor's Pap smear for cervical cancer screening. It focuses on helping minority women aged 25-65 who have fallen behind on their screenings, often due to barriers like langua…

This study aims to find the hidden genetic causes of a serious condition where fluid builds up abnormally in unborn or newborn babies, often with no known reason. Researchers will use two advanced genetic tests on families (mother, father, and baby) when standard testing has fail…

This study is testing whether a smartphone-based self-help therapy program can reduce anxiety and depression in adults living with cystic fibrosis (CF). The program, called the ACT with CF Self-Help Toolkit, uses short video lessons to teach new ways to manage difficult feelings …

This study aims to find the best schedule for giving common, non-opioid pain medications after a cesarean delivery. Researchers are comparing whether taking acetaminophen and ibuprofen at the same time or staggering them throughout the day provides better pain control. The goal i…

This study is testing whether cancer patients with low blood counts can safely receive blood transfusions at home instead of at the hospital. Researchers will enroll 30 patients who regularly need blood transfusions and give them 1-5 transfusions at home. The main goal is to see …

This study aims to understand if the stiffness of a patient's arteries can predict how well they respond to a temporary heart pump called an intra-aortic balloon pump. Researchers will observe 20 adults with severe heart failure (cardiogenic shock) who are already receiving this …

This study aims to test a simple method for understanding the daily lives of breast cancer survivors. Researchers want to see if a 14-day mobile phone diary is a practical way to track daily stress and thinking patterns. They will recruit 30 diverse survivors who are at least fiv…

This study aims to understand if a person's life circumstances—like income, housing, and stress levels—are linked to inflammation in the body, which can affect breast cancer. Researchers will enroll 200 women with newly diagnosed breast cancer who haven't started treatment. Parti…

This study is testing whether having a trained peer navigator helps African American men with advanced prostate cancer understand and go through genetic testing better than standard care alone. Genetic testing is important for treatment decisions, but many men face barriers like …

This study aims to understand if the order a surgeon cuts the blood vessels during lung cancer surgery affects how much cancer DNA is left in the bloodstream afterward. Researchers will compare two standard techniques—cutting the vein first versus cutting the artery first—in 100 …

This study aims to collect breast cancer tissue and blood samples from patients to build a research repository. The goal is to analyze these samples to better understand the disease, identify biomarkers, and study its genetic makeup. Participants will provide samples during their…

This study aims to understand why cancer patients who report needs like transportation, food, or housing problems choose not to accept help when it's offered. Researchers will survey 500 patients and interview some to learn about barriers like mistrust, feeling others need help m…

This study is testing a special type of heart scan to see if radiation therapy for lung or esophageal cancer causes damage to the heart. Researchers will scan patients' hearts before, during, and after their cancer radiation treatment to look for changes. The goal is to learn if …