Timing of pain pills after C-Section could reduce need for opioids

NCT ID NCT07102641

Recruiting now Symptom relief Sponsor: Thomas Jefferson University Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jun 26, 2026 · Updated 1 time

Summary

This study compares two schedules for taking non-opioid pain relievers (acetaminophen and NSAIDs) after a cesarean delivery: taking them at different times (staggered) or at the same time (simultaneous). The goal is to see which approach better controls pain and reduces the need for stronger opioid drugs. The trial will enroll 825 women who have a C-section under regional anesthesia.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: acetaminophen and NSAIDs (ketorolac/ibuprofen)
What this could lead to: If it works, this could establish a simple, non-opioid dosing schedule to improve pain control after C-sections.
What could go wrong: This is a Phase 4 trial comparing two common approaches, so the difference may be small. Results may not apply to all patients or settings.

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Conditions

The condition(s) this trial relates to.

Pain, Postoperative paracetamol poisoning

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ACETAMINOPHEN (D000082) CESAREAN DELIVERY NSAIDS POST-OPERATIVE PAIN POSTPARTUM COMFORT POSTPARTUM PAIN

Contacts and locations

Locations

Thomas Jefferson University Hospital
RECRUITING

Philadelphia, Pennsylvania, 19107, United States

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