POST-OPERATIVE PAIN

This study is testing whether giving methadone after major spine surgery can help patients avoid long-term dependence on opioid painkillers. Researchers will enroll 120 adults undergoing complex back surgery to see if this approach is safe and practical. The goal is to collect da…

This study aims to find the best way to treat a severe, painful tooth infection while preserving more of the natural tooth. It will compare three different dental procedures in 99 patients with painful, deeply decayed back teeth. The researchers will track patients' pain levels a…

This study aims to find the best way to schedule common pain medications after a cesarean delivery. Researchers are comparing whether taking acetaminophen and ibuprofen at the same time or staggering them throughout the day provides better pain control. The goal is to help new pa…

This study aims to see which of two add-on drugs, dexmedetomidine or dexamethasone, works better when mixed with a standard numbing shot for arm surgery. Researchers will give the nerve block to 44 adults having upper limb surgery to see which drug helps the numbness start faster…

This study is testing whether a newer, longer-lasting numbing medicine (liposomal bupivacaine) works better than a standard numbing medicine to control pain after spinal fusion surgery for scoliosis. Researchers want to see if the newer medicine helps teens use fewer opioid paink…

This study aims to find the best way to manage pain after a planned cesarean section. Researchers will compare a newer nerve-blocking injection (Erector Spinae Plane Block) with the standard morphine injection given in the spine. They will measure which method leads to a better o…

This study aims to find the best way to manage pain after total shoulder replacement surgery. Researchers are comparing a single long-acting numbing injection to a temporary catheter that delivers numbing medicine for 1-2 days. The study will measure pain levels, opioid medicatio…

This study is testing if using a special laser together with ultrasound during a root canal procedure can help reduce pain and kill more bacteria afterwards. It will involve 120 adults with a specific type of infected tooth. The main goal is to see if this combination leads to le…

This study aims to find the best way to manage pain after a cesarean delivery (C-section). Researchers are comparing two groups: one receives a continuous infusion of a local numbing medicine (bupivacaine) at the incision site, and the other receives a harmless saltwater solution…

This study aims to see if using a robotic system to perform sleeve gastrectomy (a common weight loss surgery) causes less pain right after surgery compared to the standard laparoscopic (keyhole) method. It will involve 91 patients at the Cleveland Clinic who are eligible for this…

This study is testing if using red light instead of the standard blue light to harden dental fillings causes less heat and leads to less pain afterward. Researchers will measure the temperature in the tooth and gum during the procedure in 50 participants and ask about any sensiti…

This study aims to find out which method works better for controlling pain after common outpatient orthopedic surgeries like ACL reconstruction and rotator cuff repair. Researchers will compare a continuous pain pump that delivers medication over several days to a single nerve-bl…

This study aims to find the best way to deliver morphine for pain relief after planned cesarean sections. Researchers will compare pain control between morphine injected into the spinal fluid versus morphine injected into the epidural space near the spine. The trial involves 120 …

This study compares two approaches to managing pain after laparoscopic tubal sterilization surgery. Researchers want to see if a combination of non-opioid medications and thorough patient counseling works just as well for pain relief as a standard regimen that includes opioid pil…

This study aims to find out which type of root canal sealer causes less pain after treatment. Researchers will compare pain levels in 180 patients who receive either a resin-based sealer or a bioceramic-based sealer. Patients will rate their pain on a simple scale at 24 and 48 ho…

This study is testing if a special 'prehabilitation' program helps women recover better from surgery for gynecologic cancers like ovarian or endometrial cancer. The program involves tailored exercise and nutritional support before surgery, combined with a proven fast-track recove…

This study is testing if giving a single dose of methadone during knee replacement surgery helps reduce pain and the need for strong opioid painkillers afterward. It involves 162 adults getting elective knee surgery under spinal anesthesia. The goal is to see if this method leads…

This study is testing a small, dissolvable steroid insert placed in the eye's tear duct against standard steroid eye drops. The goal is to see which method better controls pain and inflammation after surgery for certain retinal conditions. It's for adults having a specific type o…

This study is testing whether giving a medication called acetazolamide before a laparoscopic hysterectomy can help reduce common post-surgery pain. The pain often comes from gas used during the procedure, which can cause shoulder and abdominal discomfort. Researchers will compare…

This study is testing if adding a steroid medication (prednisone) to standard pain medicine helps people feel better after surgery to remove kidney stones. Researchers will enroll 90 adults who are having this surgery and getting a temporary internal tube called a stent. They wil…

This study aims to find the better of two ultrasound-guided nerve block techniques for reducing pain when patients with a broken thigh bone need to sit up for spinal anesthesia before surgery. It will involve 70 adults with femur fractures. The main goal is to see which method ma…

This study is testing whether a long-acting numbing medicine, injected directly into the surgical area, can better control pain and help swallowing function after robotic surgery for throat cancer. Researchers will compare patients who receive this injection to those who do not, …

This study is testing a new way to measure pain after surgery. The goal is to see if a new scale, which considers both pain level and how much it limits a patient's ability to move and do activities, leads to better decisions about giving extra pain medicine. Researchers will com…

This study is testing whether giving a single dose of methadone during hip replacement surgery helps reduce pain and the need for opioid painkillers afterward. Researchers will compare methadone to standard pain control in 162 adults having elective hip replacement. The goal is t…

This study aims to see if a newer, faster root canal cleaning method causes less pain after the procedure than the standard method. Researchers will enroll 34 adults with painful tooth infections and randomly assign them to receive one of the two techniques. They will measure pat…

This study is testing whether a precise nerve block, guided by ultrasound, can help control pain after middle ear surgery. The goal is to see if this method reduces the need for strong painkillers like morphine and improves patient comfort. Researchers are enrolling 56 adults und…

This study aims to understand how daily pain, mood, and activities are connected by having 800 participants use a smartphone app called SOMA for four months. The goal is to find patterns that might predict when short-term (acute) pain becomes long-term (chronic) pain. A smaller g…

This study aims to understand why pain after spine surgery is often more severe and harder to manage for people with opioid use disorder. Researchers will compare 40 patients with and without opioid use, collecting small blood and skin samples to look for biological differences i…

This study aims to understand and reduce pain, numbness, and taste changes that can happen after throat surgery. Researchers will measure the pressure placed on the tongue during surgery for 100 patients. For the second half of patients, surgeons will see these pressure readings …