POST OPERATIVE PAIN

This study tests three ways to treat deep cavities that cause severe, constant tooth pain. About 99 people will get either a partial pulp removal, a deeper pulp removal, or a full root canal. The goal is to see which method reduces pain best and keeps the tooth healthy for up to …

This study looks at two methods to control pain after outpatient orthopedic surgeries like ACL repair or rotator cuff surgery. One group gets a continuous pain pump that delivers numbing medicine for days, while the other gets a single nerve block before surgery. Researchers will…

This study tests whether injecting a long-lasting anesthetic (EXPAREL) into the surgical wound during robotic throat surgery can reduce pain, lower the need for opioids, and help patients swallow better after the operation. About 80 adults with oropharyngeal cancer will take part…

This study looks at whether a continuous infusion of the numbing medicine bupivacaine through a pump placed in the incision after a C-section helps reduce the need for stronger painkillers like opioids. About 100 pregnant women having C-sections at the Colorado Fetal Care Center …

This study compares two ultrasound-guided nerve blocks—serratus intercostal plane block and erector spinae plane block—for pain control after open nephrectomy (kidney removal). About 132 adults aged 18-65 will be randomly assigned to receive one of the two blocks during surgery. …

This study tests whether an ultrasound-guided nerve block (auricularis magnus block) can reduce pain and the need for strong painkillers after middle ear surgery. About 56 adults having elective ear surgery will receive the block or standard care. The goal is to improve recovery …

This study compares two types of nerve blocks—SIFI and QIPB—for pain relief after hip fracture surgery in 70 adults. Both blocks aim to reduce pain and the need for strong painkillers like opioids. The goal is to find which method works better to help patients recover more comfor…

This study compares two ways of giving morphine after a planned C-section: one injected into the spinal fluid and one into the space around the spinal cord. The goal is to see which provides better pain relief with fewer side effects like nausea or itching. About 120 women will t…

This study tests whether giving a single dose of methadone during hip replacement surgery can lower pain and reduce the amount of other opioids needed after the operation. About 162 adults having elective hip replacement will take part. Half will receive methadone and half a plac…

This study compares two ways of deciding when to give extra pain medicine after surgery. One method uses a standard pain scale, while the other also considers how much pain limits movement. The goal is to see if the new method reduces unnecessary painkiller use. About 76 adults h…

This study compares two ways of doing root canals to see which one causes less pain afterward. It involves 34 adults with infected back teeth. Researchers will also measure pain-related brain chemicals to understand why pain happens.

This study tests a special nerve block (M-TAPA) to see if it reduces pain better than standard numbing medicine for children after laparoscopic belly surgery. Sixty children aged 1 to 7 will be randomly assigned to receive either the nerve block or the usual numbing injection at …

This study looks at whether a steroid called prednisone can help reduce pain after a procedure to remove kidney stones (ureteroscopy). About 90 adults who are having this surgery and getting a stent placed will be given prednisone along with their usual pain medicines. The goal i…

This study tests whether a presacral nerve block can reduce pain after total laparoscopic hysterectomy. Sixty women will be randomly assigned to receive either the nerve block or a placebo (sham block). The main goal is to measure pain levels 3 hours after surgery using a standar…

This study tests whether freezing certain nerves (cryoablation) during total knee replacement can lower pain and the need for opioid painkillers afterward. About 215 adults scheduled for knee replacement will be randomly assigned to receive either standard surgery or surgery plus…

This study tests whether using a special laser along with standard ultrasonic cleaning can reduce pain and kill more bacteria after a root canal. About 120 adults with infected single-root teeth will be randomly assigned to get either the laser combo or standard care. The main go…

This study tests a small steroid insert placed in the tear duct to control pain and inflammation after vitreoretinal eye surgery. About 30 adults having surgery for a macular hole, epiretinal membrane, or vitreomacular traction will either get the insert or standard steroid eye d…

This study compares two numbing drugs injected during spinal fusion surgery for teens with scoliosis. One drug lasts longer, and researchers want to see if it reduces the need for strong painkillers like opioids in the first 3 days after surgery. About 128 teens aged 10-17 will t…

This study tests if giving dextromethorphan (a cough suppressant) before knee replacement surgery can reduce pain and the need for strong painkillers afterward. About 160 adults will receive either the drug or a placebo. The goal is to see if this simple, low-cost approach can im…

This study looks at whether giving methadone during and after major spine surgery can lower the need for long-term opioid painkillers. About 120 adults having multi-level spine fusion will be randomly assigned to receive methadone or a placebo. The main goal is to see if this app…

This study looks at the best way to schedule two common pain relievers (acetaminophen and NSAIDs) after a cesarean delivery. About 825 women who have a C-section will be randomly assigned to take the medicines at the same time or at different times. The goal is to see which sched…

This study is testing whether adding a drug called Suzetrigine to standard pain relief can lower the amount of strong opioids needed after weight-loss or heart surgery. About 235 adults having these surgeries will be randomly assigned to receive either Suzetrigine or a placebo al…

This study compares pain after root canal treatment using two different sealing materials: a resin-based sealer (AH Plus) and a bioceramic sealer (MTA Fillapex). About 180 adults with infected single-rooted teeth will be randomly assigned to one of the two groups. Pain levels wil…

This study tests whether a new pain medication called Suzetrigine can help people who have knee replacement surgery use fewer opioids and feel less pain. About 235 adults having knee replacement will be randomly assigned to get either Suzetrigine or a placebo before surgery. The …

This study tests whether a pain management plan without opioids works just as well as one with opioids after a laparoscopic tubal sterilization (getting your tubes tied). About 120 women having this surgery will be randomly assigned to one of two pain control plans. The goal is t…

This study looks at whether a pre-surgery program of exercise and a special nutritional drink (Ocoxin®) can help women with gynecologic cancers recover better after surgery. About 100 participants will follow this program alongside standard ERAS recovery steps. The goal is to see…

This study tests whether giving a single dose of methadone during knee replacement surgery can lower pain and reduce the amount of other opioids needed after the operation. About 162 adults having elective knee replacement will take part. Half will receive methadone and half a pl…

This study compares two methods of pain control after total shoulder replacement: a single injection of a long-lasting numbing medicine (Exparel) versus a small tube (catheter) that delivers numbing medicine continuously. About 56 adults having shoulder replacement will be random…

This study tests whether giving acetazolamide (Diamox) before laparoscopic hysterectomy can reduce pain after surgery, especially pain from the gas used in the abdomen. About 100 women aged 21-65 having the surgery for non-cancer reasons will take either the drug or a placebo. Th…

This study compares two ultrasound-guided nerve blocks (S-FICB and PENG) to see which one better reduces pain when positioning patients for spinal anesthesia during femur fracture surgery. About 70 adults aged 20-70 will participate. The goal is to find the block that provides be…

This study looks at a procedure called cryoanalgesia, where doctors freeze certain nerves in the chest during heart or lung surgery to reduce pain afterward. Researchers will track up to 5,000 patients aged 12 and older for up to 5 years to see how well it works and if it is safe…

This study compares two types of weight-loss surgery—robotic and laparoscopic sleeve gastrectomy—to see which causes less pain the day after surgery. About 91 adults who qualify for weight-loss surgery will be randomly assigned to one of the two procedures. The main goal is to me…

This study compares two pain management methods after a planned C-section: a nerve block (erector spinae plane block) versus morphine given during spinal anesthesia. The goal is to see which approach leads to a better recovery experience for mothers. About 52 women will participa…

This study compares two common medications, dexmedetomidine and dexamethasone, when added to a nerve block for arm surgery. The goal is to see which one helps the block work faster, last longer, and reduce the need for painkillers afterward. About 44 adults aged 18-70 having uppe…

This study uses a smartphone app called SOMA to track daily mood, pain, and activity in 800 people with acute or chronic pain, as well as healthy volunteers, over four months. The goal is to find patterns that predict whether pain becomes long-term, improves, or flares up. A smal…

This study looks at the forces placed on the tongue and throat during laryngeal surgery. Researchers want to see if these forces cause pain, numbness, or other problems after surgery. The study involves 100 adults having throat surgery. In the first 50 patients, forces are measur…

This study looks at why people with chronic pain or opioid use disorder often have worse pain after spine surgery. Researchers will collect small skin and blood samples to study genes and immune cells linked to pain. The goal is to find biological markers that could lead to bette…

This study compares red light and blue light used in dental procedures to see which causes less heat and less pain afterward. Researchers will measure temperature changes in the tooth during treatment and check in with 50 participants after their procedure. The goal is to find ou…