POST OPERATIVE PAIN

This study tested whether taking tramadol or naproxen sodium one hour before a dental procedure helps local anesthesia work better and reduces pain afterward. 139 adults with severe tooth inflammation (irreversible pulpitis) in a lower molar were randomly given one of the two dru…

This study tested whether changing the amount (volume) of a numbing medicine called ropivacaine affects pain relief after abdominal surgery. 31 patients having a total abdominal hysterectomy received one of three different volumes injected into the abdominal wall. The goal was to…

This study tested whether giving multiple doses of gabapentin before and after total knee replacement surgery can reduce the amount of morphine needed for pain. 101 adults having elective knee replacement took part. The goal was to see if gabapentin could lower pain and morphine-…

This study tested whether a long-lasting numbing medicine called Exparel (liposomal bupivacaine) can reduce pain and the need for strong painkillers after wisdom tooth removal. 85 adults having both lower wisdom teeth taken out took part. The medicine was given at the end of surg…

This study looked at 240 adults who had heart surgery to see if giving pain medicine in small, timed doses (boluses) works better than a steady drip (continuous infusion) through a catheter near the spine. The goal was to reduce pain and the need for opioids after surgery. Result…

This study tested two types of nerve blocks to control pain after collarbone surgery. Fifty adults received either a standard block near the neck or a newer block near the collarbone. The goal was to see which provides longer pain relief and causes fewer breathing problems.

This study tested whether a non-opioid pain drug called suzetrigine can control pain after outpatient facial plastic surgery and reduce the need for opioid pills. 100 adults took part at Mayo Clinic. Researchers measured how many opioid pills were used in the first week and how m…

This study tested an experimental long-acting local anesthetic called CPL-01 in 616 people having bunion surgery. The goal was to see if it reduces pain and the need for opioid painkillers after the operation compared to a standard anesthetic or a placebo. Participants received t…

This study tested a new local anesthetic called CPL-01 to control pain after open inguinal hernia repair. 518 adults received either CPL-01, a placebo, or an active control injection right after surgery. Researchers measured pain levels during activity over time to see if CPL-01 …

This study tested whether giving numbing medicine through a thin tube (catheter) placed in the spine provides better pain relief after hip surgery than a single injection. 105 patients over age 60 were randomly assigned to one of three groups: continuous spinal anesthesia, single…

This study looked at whether a simple genetic test can help doctors choose safer and more effective painkillers for women after major gynecologic surgery. About 112 women participated, and half had their pain medicine chosen based on their genes while the other half received stan…

This study compared two ultrasound-guided nerve blocks—transversalis fascia plane block and erector spinae plane block—for pain relief after inguinal hernia repair. Forty-three men undergoing open hernia surgery received one of the two blocks before the procedure. The goal was to…

This study looked at 168 adults with a silent tooth infection (asymptomatic apical periodontitis) to see if different root canal shaping tools affect pain after the procedure. Participants received one of four shaping methods, including using a single file or combining files. The…

This study tested whether a nerve block placed near the breastbone after heart surgery can reduce the need for opioid painkillers. 340 adults having heart surgery through a standard chest incision were randomly assigned to receive either the numbing drug ropivacaine or a saltwate…

This completed study compared two ways to control pain after radical cystectomy (bladder removal) surgery: thoracic epidural analgesia (TEA) and ultrasound-guided erector spinae plane (ESP) block. Twenty patients aged 40-70 were enrolled. The goal was to see which method provides…

This study tested whether adding dexamethasone or magnesium sulfate to a standard numbing drug (bupivacaine) could provide longer pain relief after total hip replacement. 66 adults received an ultrasound-guided nerve block before surgery. The main goal was to see how long it took…

This study tested whether adding dexmedetomidine to a standard numbing medicine (bupivacaine) in chest nerve blocks could provide better pain relief after heart surgery. Sixty adults having open-heart surgery through a chest incision received the nerve block with or without the e…

This study tested two types of nerve blocks (erector spinae plane block and serratus anterior plane block) to see which provides better pain relief after breast reduction surgery. 80 women received one of the two blocks, and researchers measured how much pain medication they need…

This study tested two different nerve blocks to see which one works better for pain after laparoscopic inguinal hernia surgery. 90 adults received either a modified thoracoabdominal nerve block (M-TAPA) or a standard transversus abdominis plane (TAP) block. Researchers measured p…

This study tested whether applying cold therapy (cryotherapy) inside the mouth or inside the tooth itself can reduce pain and inflammation after root canal treatment. Thirty adults with painful tooth infections received either an oral cold pack, a cold saline rinse inside the too…

This study tested whether adding a nerve-freezing procedure (genicular nerve radiofrequency ablation) to standard knee replacement surgery could reduce pain and improve knee function afterward. Seventy adults with advanced knee osteoarthritis took part. The goal was to see if the…

This study tested a new drug called MR-107A-02 for treating acute pain after hernia repair surgery. About 579 adults took part, comparing the drug to a placebo and to tramadol, a standard painkiller. The goal was to see if MR-107A-02 reduces pain intensity and the need for extra …

This study tested three different pain-relief methods in 102 adults having keyhole lung surgery. The goal was to see which method keeps patients comfortable the longest after the operation. Researchers measured how soon patients needed extra pain medicine and how strong their pai…

This study tested whether a quadratus lumborum (QL) nerve block can reduce pain and the need for opioid painkillers after robotic surgery for pelvic organ prolapse. 70 women were randomly assigned to receive either the QL block or standard enhanced recovery care. Researchers meas…

This study looked at whether using sonic irrigation or a diode laser during root canal treatment reduces pain afterward. Eighty adults with infected single-rooted teeth were randomly assigned to one of four cleaning methods. Patients reported their pain levels and painkiller use …

This study tested a single injection of F14, a long-acting form of the painkiller celecoxib, given directly into the knee joint during total knee replacement surgery. The goal was to see if it provides better pain relief than standard pain medicines alone. The trial involved 151 …

This study looked at 60 adults aged 18-65 having partial hip replacement to compare two spinal anesthesia methods: hypobaric (light) and hyperbaric (heavy). The goal was to see which one keeps blood pressure more stable and reduces pain after surgery. Researchers measured pain us…

This study tested two methods to control pain after heart surgery done through a small cut in the chest. One method freezes the nerves between the ribs during surgery, and the other injects a numbing medicine near those nerves after surgery. The goal was to see which approach pro…

This study tested two methods to control pain after a mastectomy: a nerve block in the back (erector spinae plane block) and numbing medicine injected into the wound. 37 women took part. The goal was to see which approach reduces pain and the need for morphine in the first day af…

This study tested whether adding a steroid (dexamethasone) to a standard nerve block could provide longer pain relief after knee replacement surgery. 66 adults scheduled for knee replacement received the nerve block with or without the steroid. The main goal was to see if the ste…

This study looked at two methods of giving a nerve block to control pain after lumbar spinal fusion surgery. One method used ultrasound to guide the injection, while the other was done by the surgeon during the operation. Both used a mix of numbing medicine and a drug that helps …

This study tested whether adding magnesium to the anesthetic bupivacaine for a nerve block around the knee provides better pain relief after total knee replacement surgery. 94 adults undergoing knee replacement were randomly assigned to receive either bupivacaine with magnesium o…

This study tested whether a multiport epidural catheter (with three side holes) provides better pain relief than a standard uniport catheter (with one end hole) after chest or upper abdominal surgery. Researchers enrolled 240 adults and measured how often the catheter failed, mea…

This study tested a new drug called MR-107A-02 for treating acute pain after bunionectomy (foot surgery). 410 adults received either the new drug, a placebo, or tramadol (a standard painkiller). The main goal was to see if MR-107A-02 provides better pain relief than placebo, meas…

This study tested whether using a sonic device (EndoActivator) to clean the tooth during a root canal reduces pain afterward. Fifty-eight adults with tooth infections were randomly assigned to get either the sonic cleaning or standard syringe irrigation. Pain was measured before …

This completed early-phase trial tested three oral painkillers—Novafen, Tramadol, and Naproxen—against a placebo (multivitamins) for pain after root canal treatment. 100 adults with tooth pain took one of the four options, and their pain was measured on a 0–10 scale. The goal was…

This study tested whether the 4-7-8 breathing technique (breathe in for 4 seconds, hold for 7, out for 8) can help with pain, nausea, and vomiting after bariatric surgery. Sixty patients were split into two groups: one practiced the breathing technique hourly, the other received …

This study tested whether giving ketamine during surgery and methadone after surgery can prevent a condition called opioid-induced hyperalgesia, where painkillers actually make pain worse. 113 patients having open colorectal surgery took part. Researchers measured the area of inc…

This study tested three different nerve blocks to control pain after shoulder surgery in 40 adults. The goal was to see if a newer block could provide good pain relief without the side effects of the standard block. Researchers measured pain using a scale from 0 to 100.