POST-OPERATIVE PAIN

This study tested whether an investigational drug called MR-107A-02 works better than a placebo (inactive pill) or standard pain medication for relieving acute pain after bunion removal surgery. It involved 410 patients who had moderate to severe pain after their nerve block wore…

This study compared two different nerve block techniques for reducing pain after laparoscopic hernia surgery. Researchers tested the M-TAPA block and the TAP block on 90 patients to see which provided better pain relief. All patients received standard pain medications, and resear…

This study tested whether adding magnesium to a standard pain-blocking medication provides better pain relief after total knee replacement surgery. Researchers compared the magnesium combination against the standard medication alone in 94 patients. The goal was to see if the magn…

This study tested if a specific nerve block could better manage pain after a common pelvic surgery. It involved 70 women having surgery for pelvic organ prolapse. Researchers compared standard pain care to the same care plus a nerve block to see which led to less pain and lower o…

This study compared two types of epidural catheters (thin tubes placed in the back to deliver pain medication) to see which works better for controlling pain after chest or abdominal surgery. Researchers tested whether catheters with multiple side holes provide more effective and…

This study tested if a special sonic tool for cleaning the tooth during a root canal reduces pain afterward. 58 patients were randomly assigned to get either the sonic cleaning or the standard syringe cleaning. Researchers measured their pain levels for a week after the procedure…

This study tested two ways to deliver pain-relieving nerve blocks after spinal fusion surgery. Researchers compared ultrasound-guided injections performed by an anesthesiologist against injections done directly by surgeons during the operation. The goal was to see which method be…

This study tested whether a local anesthetic block, given through small tubes near the breastbone, could reduce the need for strong opioid painkillers after open-heart surgery. Researchers compared the anesthetic to a saltwater placebo in 340 patients. The main goal was to see if…

This study compared two different nerve block techniques to manage pain after breast reduction surgery. Researchers tested whether injections near the spine (erector spinae block) or near the shoulder blade (serratus anterior block) work better to reduce pain and limit opioid med…

This study tested whether a simple breathing exercise could help people feel better after weight loss surgery. Researchers taught 60 patients a specific 4-7-8 breathing pattern to use hourly after their operation. They then compared the pain and nausea levels of these patients to…

This study tested whether adding common medications (dexamethasone or magnesium sulfate) to a standard numbing injection in the lower back could better control pain after hip replacement surgery. Researchers compared how long pain relief lasted and how much extra pain medication …

This study compared two different nerve-block techniques to see which one better controls pain after inguinal hernia repair surgery. Researchers tested these methods on 43 male patients to help reduce the need for strong painkillers after the operation. The goal was to find a saf…

This study compared two different nerve-blocking techniques to manage pain after shoulder surgery. Researchers tested a newer method (paracoracoid subscapularis block) against a more established one (infraclavicular/subomohoid block) in 40 patients. The goal was to see which tech…

This study tested whether using special sonic tools or a laser during root canal treatment could reduce pain afterwards. 80 patients with a specific tooth infection but no pain received one of four cleaning methods. The results showed no significant difference in pain levels or p…

This small study compared two different methods for managing pain after major bladder cancer surgery. Researchers tested whether a newer ultrasound-guided nerve block works as well as the traditional epidural for pain relief. The trial involved 20 patients undergoing bladder remo…

This study tested whether adding a medication called dexmedetomidine to a standard numbing injection could improve pain relief after major heart surgery. Researchers compared two groups of 30 patients each who received different versions of a nerve block procedure after their ope…

This study tested if adding a common steroid (dexamethasone) to a standard numbing injection could provide longer-lasting pain relief after knee replacement surgery. It involved 66 patients who received either the standard injection or the injection with the added steroid. The ma…

This study tested if adding a nerve treatment during knee replacement surgery helps patients recover with less pain and better function. It compared standard knee replacement surgery to surgery that also included a procedure to block pain signals from knee nerves. The study invol…

This study compared two methods for managing severe pain after minimally invasive heart surgery. Researchers observed 63 adult patients to see if freezing the nerves between the ribs (cryoanalgesia) or injecting a numbing medication (BRILMA block) worked better. The goal was to f…

This study compared two types of spinal anesthesia used during partial hip replacement surgery to see which one better maintains stable vital signs and provides longer-lasting pain relief after the operation. Researchers monitored 60 patients to measure their pain levels, recover…

This completed Phase 3 study tested whether a single injection of F14 (a long-acting pain medication) given during knee replacement surgery provides better pain relief than standard pain treatments alone. The trial involved 151 adults aged 45-80 undergoing knee replacement. Resea…

This study tested which of three common painkillers works best to reduce pain after the first part of a root canal. 100 patients with tooth pain were given either a placebo (fake pill), tramadol, Novafen (a mix of acetaminophen, ibuprofen, and caffeine), or naproxen right after t…

This study tested whether an investigational drug called MR-107A-02 could safely and effectively relieve acute pain after hernia repair surgery. It involved 579 adults who had just undergone the operation and were experiencing moderate to severe pain. The drug was compared agains…

This study aimed to find out if using different combinations of small dental files during a root canal procedure affects how much pain patients feel afterwards. Researchers treated 168 adults with a specific tooth infection but no current pain, using one of four slightly differen…

This study tested three different methods for managing pain after a specific type of minimally invasive chest surgery. Researchers compared how well each method worked to reduce pain and delay the need for additional pain medication. The goal was to find the most effective approa…

This study compared two methods for managing pain after breast cancer surgery. Researchers tested whether an ultrasound-guided nerve block in the back was more effective than injecting pain medication directly into the surgical wound. The goal was to find the best way to reduce p…

This study tested whether giving the drugs ketamine during surgery and methadone after surgery could prevent a common problem: strong painkillers (opioids) sometimes make patients more sensitive to pain around their surgical wound. Researchers enrolled 113 patients having abdomin…

This study tested if applying cold therapy could reduce pain and inflammation after a root canal procedure for a painful tooth infection. Researchers compared applying an ice pack to the cheek versus rinsing the tooth's root with cold saline, against a standard treatment with no …