New shot could ease pain after knee surgery, cut need for opioids

NCT ID NCT05603832

First seen Jan 04, 2026 · Last updated May 08, 2026 · Updated 14 times

Summary

This study tested a single injection of F14, a slow-release painkiller, in 151 adults having knee replacement surgery. The goal was to see if it reduces pain and the need for opioid painkillers after surgery. Results suggest it may improve pain control and knee movement during recovery.

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Contacts and locations

Locations

  • CenExel JBR

    Salt Lake City, Utah, 84107, United States

  • Endeavor Clinical Trials

    San Antonio, Texas, 78240, United States

  • HD Research - First Surgical Hospital

    Bellaire, Texas, 77401, United States

  • HD Research - Legent Orthopedic Hospital

    Carrollton, Texas, 75006, United States

  • Phoenix Clinical Research

    Tamarac, Florida, 33321, United States

  • The Orthopedic Center

    Tulsa, Oklahoma, 74104, United States

  • Woodland International Research Group

    Little Rock, Arkansas, 72211, United States

Conditions

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