New shot could ease pain after knee surgery, cut opioid use

NCT ID NCT05603832

Completed Symptom relief Sponsor: Arthritis Innovation Corporation Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tested a single injection of F14, a long-acting form of the painkiller celecoxib, given directly into the knee joint during total knee replacement surgery. The goal was to see if it provides better pain relief than standard pain medicines alone. The trial involved 151 adults aged 45 to 80 and has already been completed.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: F14 (sustained-release celecoxib)
What this could lead to: If successful, F14 could provide longer-lasting pain relief after knee replacement surgery, reducing the need for opioids.
What could go wrong: This is a completed Phase 3 trial, but results are not yet published. The benefit over standard pain management may be modest, and side effects like those of other NSAIDs (e.g., stomach or kidney issues) are possible.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

Pain, Postoperative

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

POST-OPERATIVE PAIN

Contacts and locations

Locations

CenExel JBR

Salt Lake City, Utah, 84107, United States
Endeavor Clinical Trials

San Antonio, Texas, 78240, United States
HD Research - First Surgical Hospital

Bellaire, Texas, 77401, United States
HD Research - Legent Orthopedic Hospital

Carrollton, Texas, 75006, United States
Phoenix Clinical Research

Tamarac, Florida, 33321, United States
The Orthopedic Center

Tulsa, Oklahoma, 74104, United States
Woodland International Research Group

Little Rock, Arkansas, 72211, United States

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