New shot could ease pain after knee surgery, cut opioid use
NCT ID NCT05603832
First seen Jan 04, 2026 · Last updated Jun 23, 2026 · Updated 21 times
Summary
This study tested a single injection of F14, a long-acting form of the painkiller celecoxib, given directly into the knee joint during total knee replacement surgery. The goal was to see if it provides better pain relief than standard pain medicines alone. The trial involved 151 adults aged 45 to 80 and has already been completed.
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This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Locations
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CenExel JBR
Salt Lake City, Utah, 84107, United States
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Endeavor Clinical Trials
San Antonio, Texas, 78240, United States
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HD Research - First Surgical Hospital
Bellaire, Texas, 77401, United States
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HD Research - Legent Orthopedic Hospital
Carrollton, Texas, 75006, United States
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Phoenix Clinical Research
Tamarac, Florida, 33321, United States
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The Orthopedic Center
Tulsa, Oklahoma, 74104, United States
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Woodland International Research Group
Little Rock, Arkansas, 72211, United States
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
F14 (sustained-release celecoxib)
What this could lead to
If successful, F14 could provide longer-lasting pain relief after knee replacement surgery, reducing the need for opioids.
What could go wrong
This is a completed Phase 3 trial, but results are not yet published. The benefit over standard pain management may be modest, and side effects like those of other NSAIDs (e.g., stomach or kidney issues) are possible.
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.