Toothache relief: could a pill before the dentist make root canals Pain-Free?
NCT ID NCT05982392
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study tested whether taking tramadol or naproxen sodium one hour before a dental procedure helps local anesthesia work better and reduces pain afterward. 139 adults with severe tooth inflammation (irreversible pulpitis) in a lower molar were randomly given one of the two drugs or a placebo. The main goal was to see if these pre-treatment pills made the numbing injection more effective and lowered pain during and after the procedure.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
Tramadol and Naproxen Sodium
What this could lead to
If effective, this could offer a simple way to reduce pain during and after root canal treatment for people with severe tooth inflammation.
What could go wrong
This is a small, completed trial. Results may not apply to all dental patients, and pain relief varies by individual. Side effects from these drugs are possible.
Disclaimer
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the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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Dow International Dental College
Karachi, Sindh, 75500, Pakistan