Toothache relief: could a pill before the dentist make root canals Pain-Free?

NCT ID NCT05982392

Completed Symptom relief Sponsor: Dow University of Health Sciences Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tested whether taking tramadol or naproxen sodium one hour before a dental procedure helps local anesthesia work better and reduces pain afterward. 139 adults with severe tooth inflammation (irreversible pulpitis) in a lower molar were randomly given one of the two drugs or a placebo. The main goal was to see if these pre-treatment pills made the numbing injection more effective and lowered pain during and after the procedure.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Tramadol and Naproxen Sodium
What this could lead to: If effective, this could offer a simple way to reduce pain during and after root canal treatment for people with severe tooth inflammation.
What could go wrong: This is a small, completed trial. Results may not apply to all dental patients, and pain relief varies by individual. Side effects from these drugs are possible.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

Pain, Postoperative pulpitis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

POST-OPERATIVE PAIN SYMPTOMATIC IRREVERSIBLE PULPITIS

Contacts and locations

Locations

Dow International Dental College

Karachi, Sindh, 75500, Pakistan

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