Pulpitis

This study looks at whether the position of a deep cavity (on the chewing surface or between teeth) affects how well a tooth-saving procedure called direct pulp capping works. Researchers will treat 154 people aged 15-40 with reversible pulpitis, a condition where tooth pain goes…

This study tests whether using early drug monitoring and a dose-adjustment calculator can help infants under 90 days old with sepsis reach target vancomycin levels more quickly. Currently, doctors must wait 24-48 hours to check drug levels, which can delay effective treatment. Th…

This study is testing whether a powerful antibiotic called piperacillin/tazobactam can be given as a continuous shot under the skin instead of through an IV line. About 240 adults with serious bacterial infections will be randomly assigned to receive the drug either subcutaneousl…

This study compares two dental procedures to treat deep cavities in back molars that have moderate pulpitis (inflamed tooth nerve). In one method, the dentist removes only part of the decay and places a protective material over the remaining decay. In the other, all decay is remo…

This study compares two ways of giving the antibiotic cefepime to very sick patients with sepsis in the ICU. The new method adjusts the dose based on the patient's kidney function, using only standard doses. The main goal is to see if this approach is easy for doctors to use and …

This study compares eggshell powder to Biodentine for treating tooth pulp exposure in children's baby molars. Thirty kids with deep cavities but no infection will get a pulpotomy, where the damaged pulp is removed and the material is placed. Researchers will check for pain, swell…

This study compares two dental treatments—pulpotomy and pulpectomy—for deep cavities in baby teeth that cause pain. About 40 children aged 4 to 6 will receive one of the treatments. Researchers will check x-rays and symptoms to see which approach works better and is more comforta…

This study tests whether giving zinc supplements along with standard antibiotics can reduce deaths and improve recovery in young infants (0-59 days old) hospitalized with severe infections like sepsis or pneumonia. About 3,250 babies in Tanzania will receive either zinc or a plac…

This study compares two treatments for extremely deep cavities that reach the tooth's nerve: a full pulpotomy (removing only the top part of the nerve) versus a standard root canal. About 93 people aged 12 and older with a deep cavity in a permanent tooth will be randomly assigne…

This study tests whether two forms of demineralized dentin matrix (a material made from tooth tissue) can help regenerate immature permanent teeth in children aged 9 to 15. The trial compares these materials to a standard sealing material called RetroMTA. Over 12 months, research…

This study compares two dental procedures—complete pulpotomy and root canal treatment—in 106 adults with type 2 diabetes who have a painful tooth condition called irreversible pulpitis. The goal is to see which treatment is more successful at relieving pain, healing the tooth, an…

This early-stage study tests a new imaging agent called 18F-4FN for PET scans to safely detect inflammation in the body. It involves 55 adults with cancer who are on immunotherapy or have suspected inflammation. The goal is to see if this agent can highlight areas of inflammation…

This early study is testing a radioactive tracer called [18F]F-TMP that is injected into the body and then tracked with a PET/CT scan. The goal is to see if the tracer collects at sites of bacterial infection, making them visible on the scan. Twenty adults with known or suspected…

This study tests whether injecting the steroid dexamethasone near the tooth ligament or under the gum helps numb the tooth better and reduces pain during root canal treatment. It includes 84 adults with severe, irreversible pulpitis in a lower molar. Participants receive one of t…

This study tests whether a specially prepared (buffered) numbing shot works better than the standard shot to reduce pain and anxiety in children aged 6 to 12 who need a tooth filling or root canal for an infected baby tooth. Researchers will measure pain using a behavior scale, h…

This study compares two methods of numbing the lower back teeth in children who need emergency dental treatment. One method is a standard injection near the jaw nerve, and the other uses a computer-controlled device to deliver numbing medicine directly into the tooth area. Resear…

This study tests three treatments for teeth with deep cavities and severe, constant pain: total pulpotomy, radicular pulpotomy, and standard root canal. About 99 adults will receive one of these procedures, and their pain and healing will be tracked for a year. The goal is to fin…

This study looks at whether doing breathing exercises before orthopedic surgery (like knee, hip, or fracture repair) can help your lungs work better after the operation. It involves 36 adults who have used tobacco and are at risk for breathing problems after surgery. Participants…

This study tests whether giving antibiotics through a small, portable pump over 24 hours is safe and cost-effective for children with serious bacterial infections. About 150 kids who are stable enough for home care will receive the pump instead of multiple daily hospital injectio…

This study tests whether giving patients an extra injection of a long-acting anesthetic (bupivacaine with epinephrine) right after a root canal can lower pain, improve quality of life, and reduce the need for painkillers. About 150 adults with tooth pain will be randomly assigned…

This study tests whether placing an ice pack on the gum for 5 minutes before a numbing injection can improve pain control during root canal treatment. It involves 98 adults with severe, irreversible tooth nerve pain. The goal is to see if this simple cold therapy reduces the need…

This study tests two materials, MTA and Biodentine, for treating a painful tooth condition called irreversible pulpitis. 60 adults with severe tooth pain will get a pulpotomy (removing infected pulp) and one of the materials. They will be followed for 3 months to see which materi…

This study tests whether a program of exercise and ergonomics training can reduce muscle and joint pain in teachers. About 80 teachers who have had pain for at least three months will be randomly assigned to receive the training or not. Researchers will measure changes in pain, d…

This study looks at two types of dental sealers used in root canals to see which one causes less pain afterward. About 50 adults with tooth pain will get one of the two sealers and report their pain for three days. The goal is to help dentists choose the sealer that makes root ca…

This study tests a web-based app called IAMABLE that provides evidence-based rehabilitation strategies for people with chronic conditions like heart disease, arthritis, or neurological disorders. Fifty adults aged 45 to 75 will use the app for 4 months to set goals and learn abou…

This study tests a new way to do root canals that skips the manual step of scouting and widening the canal by hand. Instead, dentists use a special rotary file from the start. The goal is to see if this causes less pain after the procedure compared to the traditional method. The …

This study tests whether using a gentle laser along with a special dental cement can reduce pain after a pulpotomy, a procedure that saves a tooth with a severe nerve infection. About 46 children and young adults aged 9 to 14 with a painful lower molar will be randomly assigned t…

This study compares a laser-based procedure to the standard method for treating severe toothache (irreversible pulpitis) in adult molars. Sixty participants will receive either laser or conventional treatment, and healing will be tracked using X-rays and AI analysis. The goal is …

This study tests whether Trinase, an enzyme-based anti-inflammatory medication, can reduce pain after root canal treatment. 182 men with moderate to severe tooth pain will receive either Trinase or a placebo 30 minutes before the procedure. Pain levels and the need for extra pain…

This study compares pain levels after root canal treatment using two different sealing materials: a resin-based sealer and a bioceramic sealer. 180 adults with a single-rooted tooth needing a root canal will be randomly assigned to one of the two sealers. Pain will be measured 24…

This study tests two different dental file systems—EdgeOne Fire (reciprocating motion) and Jizai (rotary motion)—to see which causes less pain during and after root canal treatment in upper premolars with infected pulp. Fifty-six adults with moderate spontaneous pain will be rand…

This study tests whether extra support for case managers helps veterans leaving the military better manage pain and reduce risky substance use. About 1800 veterans will take part. The program focuses on non-drug pain treatments and counseling.

This study looks at whether making the tip of a root canal wider or using different taper sizes helps the tooth heal better and causes less pain afterward. Researchers will treat 270 adults with infected, dead nerves in their lower back teeth. Participants will get one of three r…

This study looks at how the immune system changes with age and how that affects the risk of infections in people 60 and older. Researchers will collect blood, urine, stool, and other samples from elderly patients with infections and healthy older adults. By analyzing immune cells…

This study aims to learn more about rare skeletal disorders by collecting medical records, blood samples, and genetic data from 100 participants. People with known or suspected bone conditions, as well as their healthy family members, can join either remotely or in person. The go…

This study aims to improve how doctors evaluate and manage people who have been exposed to bioterrorism agents (like anthrax) or emerging infectious diseases (like SARS or new flu strains). Up to 200 participants, including patients and healthcare workers, will be monitored and t…

This study is testing a new rapid diagnostic device called In-Dx to quickly identify infections and antibiotic resistance in emergency patients with suspected sepsis. Researchers will compare the device's results to standard lab cultures using stored samples from 2,500 patients. …

This study translates and tests several health questionnaires—covering pain, arm and leg function, mood, and daily activities—for use with Albanian-speaking people. Researchers will check if the translated versions are reliable and accurate by giving them to about 300 participant…

This study tests a new tool called the PRISM Dashboard, which gives physiotherapists feedback on how their decisions compare to their peers. The goal is to see if this feedback helps reduce differences in care for people with muscle and joint pain. About 60 physiotherapists and t…

This study examines why some people with a painful tooth infection (irreversible pulpitis) don't get fully numb from a standard dental injection. Researchers will measure levels of certain genes and inflammatory markers in the tooth pulp to see if they predict anesthesia success.…

This study is observing 1,000 people with liver cirrhosis who have bacterial infections and are being treated with β-lactam antibiotics. Researchers want to see how the body processes these drugs and whether personalized dosing could improve survival. The study is observational, …

This study looks at how a patient's symptoms before treatment and how deep the cavity is affect the success of partial decay removal in adult teeth. One hundred adults with deep cavities will be treated and followed for 12-24 months. The goal is to see if these factors influence …

This study tests a new, lightweight ultrasound device called NeoDoppler that can be gently placed on a newborn's soft spot (fontanelle) to continuously measure blood flow in the brain. Researchers will enroll 180 preterm and full-term infants, including those with conditions like…

This study is looking at whether early signs of inflammation in the blood can help identify which patients with infections are at risk for serious complications like sepsis. Researchers will follow 4,200 adults with confirmed or suspected infections, as well as healthy controls, …

This study looks at whether substances in the blood from a decayed tooth can predict if a tooth-saving procedure called vital pulp treatment will succeed. Researchers will collect a small blood sample from the tooth during treatment and check for specific metabolic markers. They …

This early-stage study is testing whether a single dose of an experimental antibiotic combination (sulopenem etzadroxil plus probenecid) is safe and tolerable in 12 adolescents already receiving standard antibiotics for a bacterial infection. Researchers will measure how the drug…

This pilot study is measuring prednisolone levels in 120 people with inflammatory diseases like thyroid eye disease, vasculitis, COPD, asthma, and others. Participants take high-dose prednisolone as part of their routine care, and researchers take timed blood samples to see how t…

This study follows 252 adults with muscle, bone, or joint problems (like arthritis, back pain, or after surgery) to see how well they do their prescribed home exercises. Researchers will track who sticks with the program and why, looking at factors like pain, mood, and support. T…

This study looks at how the antibiotic ceftazidime avibactam behaves in 30 children with severe infections who are in intensive care, some on life support. Researchers will measure drug levels in the blood to understand the right dose. The goal is to improve treatment for life-th…

This study tests whether using a virtual reality (VR) headset during shoulder exercises helps patients feel more engaged and motivated. Fifty adults with shoulder problems will do rehab exercises in a VR environment and then answer questionnaires about how easy and immersive the …

This study surveys 100 French dentists who treat children to understand why they often choose extraction for non-vital baby teeth, even though effective alternatives like pulpectomy exist. The goal is to collect and analyze their treatment choices, reservations, and decision-maki…

This study looks at 320 adults who are about to start strong immune-suppressing therapy and have already had at least two COVID-19 shots. Researchers want to find out if giving a COVID-19 booster right before starting therapy or waiting six months provides better protection. Part…

This study looks at how the antifungal medicine caspofungin behaves in children with severe infections, especially those with liver problems or on life support like ECMO. Researchers will measure drug levels in the blood to understand dosing needs. About 60 children in intensive …

This study will collect data from 2,000 children admitted to pediatric intensive care units (PICUs) with severe infections across major Chinese cities. Over 10 years, researchers will track which germs cause these infections, how they are treated, and patient outcomes. The goal i…

This study looks at two common antibiotic combinations given to hospitalized adults with infections: vancomycin plus piperacillin-tazobactam, or vancomycin plus cefepime. The goal is to see if one is less likely to cause kidney injury than the other, using more sensitive markers …

This study aims to create a secure national database for muscle and joint (musculoskeletal) conditions by collecting routine data from community clinics and GP practices. About 22,000 adults will have their information anonymously gathered to help develop a dashboard that tracks …

This study watches 2000 people having hip or knee replacement surgery to see how long spinal anaesthesia lasts. The goal is to learn how the amount of anaesthetic affects timing, helping doctors decide if patients can safely go home the same day. No new treatments are tested—just…

This study tests whether artificial intelligence can predict if a less invasive procedure called full pulpotomy (removing only the infected pulp) will succeed in treating painful molars, compared to standard root canal treatment. Researchers will enroll 58 adults with irreversibl…

This study looks at how changing the heel cushion on an ankle-foot brace (AFO) affects walking in people who use one daily. Forty adults with leg injuries or nerve problems will try four different heel wedges—tall or short, soft or firm—while walking at controlled speeds. Researc…

This study looks at whether the phase of a woman's menstrual cycle changes how well dental numbing works for treating a painful tooth condition called pulpitis. Researchers will give 150 women a standard numbing shot and measure pain during treatment. The goal is to see if certai…

This study looks at how 3D computer simulation and printing can help surgeons better plan and perform bone correction surgeries. Researchers will compare the planned corrections to the actual results in 100 children and young adults with rare bone deformities. The goal is to make…

This study follows 4,000 children who receive orthopedic implants (like rods or screws) during standard care for bone fractures, deformities, or hip problems. Researchers will track how long the implants last, any complications, and how well they work over time. The goal is to ga…

This study is building a registry of people with rare bone diseases (skeletal dysplasias) in Italy. Researchers will collect medical history, genetic data, and treatment details over time to better understand how these conditions progress. No experimental treatments are given; th…

This study follows 144 adults with muscle or bone problems who are already scheduled to receive treatment with Chattanooga Intelect devices (like TENS or ultrasound). Researchers will measure pain, muscle strength, and movement range to confirm the devices are safe and work as ex…

This pilot study is testing whether a smart wristband can accurately measure drug levels in sweat compared to standard blood tests. Researchers will collect sweat, saliva, and blood samples from 100 patients with chronic or infectious diseases who are taking medications like cycl…

This study is looking for new ways to diagnose sepsis, a life-threatening reaction to infection, earlier in the emergency room. Researchers will study the immune responses of 3,300 adults with suspected infections to find patterns that signal sepsis. The goal is to improve diagno…