Could an extra shot after a root canal cut pain and pill use?

NCT ID NCT06655454

Recruiting now Symptom relief Sponsor: New York University Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tests whether giving patients an extra injection of a long-acting anesthetic (bupivacaine with epinephrine) right after a root canal can lower pain, improve quality of life, and reduce the need for painkillers. About 150 adults with tooth pain will be randomly assigned to get the extra shot, a placebo shot, or no extra shot. Researchers will track their pain and well-being for four days after treatment.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: bupivacaine with epinephrine
What this could lead to: If it works, this could give dentists a simple way to reduce pain and the need for painkillers after a root canal.
What could go wrong: This is a small, early-phase trial, so results may not apply to everyone. The extra injection might not help much more than a placebo.

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Conditions

The condition(s) this trial relates to.

agnosia pulpitis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ANALGESIC USE PAIN ASSESSMENT QUALITY OF LIFE (QOL)

Contacts and locations

Locations

New York University College of Dentistry
RECRUITING

New York, New York, 10010, United States

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