Why your dental numbing shot might not work: gene and inflammation clues
NCT ID NCT07532200
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study examines why some people with a painful tooth infection (irreversible pulpitis) don't get fully numb from a standard dental injection. Researchers will measure levels of certain genes and inflammatory markers in the tooth pulp to see if they predict anesthesia success. About 100 adults with infected lower molars will participate. The goal is to understand biological factors behind failed dental numbing, which could eventually lead to better pain control strategies.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
What this could lead to
If successful, this could help dentists predict which patients might need extra anesthesia for painful tooth infections, improving pain management.
What could go wrong
This is a small observational study, not a treatment trial. It only looks for links between genes, inflammation, and anesthesia success—it won't directly improve care yet.
Disclaimer
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the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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Faculty of Dentistry
RECRUITINGNew Delhi, National Capital Territory of Delhi, 110025, India
Contact Phone: •••-•••-•••• Email: •••••@•••••