Pulpitis

This trial compares two types of rotary files designed for children's primary molars: Fanta AF Baby and EndoArt Pedo Blue. The goal is to see which system prepares root canals faster and with better filling quality during a pulpectomy (removing infected pulp). Thirty children age…

This study tests whether oxymetazoline, a common nasal decongestant, can replace sodium hypochlorite as a bleeding control agent during pulp treatment in children's baby teeth. About 50 Egyptian children aged 4-8 with decayed molars will receive either treatment. The goal is to s…

This study tests whether a paste made from Salvadora persica (a plant used in traditional toothbrushes) mixed with zinc oxide can work as well as the standard material (MTA) for treating severe tooth inflammation. The trial involves 78 adults aged 18-40 with infected permanent mo…

This study compares rosemary extract to a standard material (MTA) for treating severe tooth pulp inflammation. Researchers will treat 100 adults with a damaged tooth, placing either rosemary extract or MTA directly on the pulp. They will then measure pain and healing over time to…

This study tests whether a robot can place dental implants more accurately than a computer-guided navigation system in the front upper jaw. Twenty-four adults needing an implant will be randomly assigned to one of the two methods. The main goal is to see which approach achieves b…

This study compares a new, simpler treatment called CTZ paste against the standard root canal procedure for infected baby teeth in emergency settings. The CTZ paste is placed directly into the tooth without drilling or cleaning the root canals, aiming to kill bacteria and save th…

This study compares two common antibiotic combinations—vancomycin with piperacillin/tazobactam versus vancomycin with meropenem—to see which is less harmful to the kidneys. About 852 hospitalized adults with serious infections will be randomly assigned to one of the two combos. T…

This study tests three special dental cements—Bio C Repair, Biodentine, and MTA—as treatments for irreversible pulpitis (nerve infection) in children's permanent molars. Sixty kids aged 6-10 will receive one of the materials after removing the infected pulp. The goal is to see wh…

This study tests whether a single rotary file system removes more bacteria from infected baby molars than traditional manual files. Thirty-four children aged 4 to 6 with irreversible pulpitis will have their root canals cleaned using one of the two methods. The main goal is to me…

This study tests a new material made from treated dentin and calcium silicate for treating deep cavities that have reached the tooth's nerve. The goal is to see if it can keep the nerve healthy better than the current standard material. Fifty-six people aged 14 to 35 with deep ca…

This study compares two treatments for irreversible pulpitis, a condition causing severe tooth pain. The standard treatment is a root canal, but researchers want to see if a less invasive procedure called pulpotomy works just as well. The study will involve 138 people and also lo…

This study tests if a less invasive procedure called partial pulpotomy using CGF (a blood concentrate) can control pain and inflammation in severely decayed permanent molars as well as standard root canal treatment. It will involve 60 adolescents aged 11-17 with intense tooth pai…

This study looks at whether an essential oil from Pelargonium graveolens (a type of geranium) can be used to treat deep cavities in children's baby teeth. The goal is to see if it works as well as current materials to relieve pain and prevent infection. Thirty children will recei…

This study looks at two methods for cleaning and filling infected baby molars in children aged 5-7. One method uses a manual tool, the other a rotating tool. The goal is to see which works better over a year. About 44 children will take part.

This study looks at whether applying cold (cryotherapy) during a pulpotomy—a procedure that removes infected nerve tissue from a tooth—improves the chance of saving the tooth. Researchers will compare treatment success in 140 healthy adults with deep cavities. Success means no pa…

This study compares two dental treatments for teeth with deep cavities and reversible pulpitis (early nerve inflammation). One treatment caps the exposed nerve directly, while the other removes a small part of the nerve before capping. The study will include 138 people aged 15-40…

This study compares two dental procedures for treating deep cavities in baby molars of children aged 6-8. One group gets a partial nerve treatment (pulpotomy) using a special cement, while the other gets a full root canal (pulpectomy) with a medicated paste. Researchers will trac…

This study tests a new root canal filling made from zinc oxide and ozonated olive oil against a standard material called Metapex in children aged 3-5 with cavities in their front teeth. Over 12 months, researchers will check for pain, swelling, and healing on X-rays. The goal is …

This study compares two dental procedures for treating infected baby molars in children aged 4 to 8. One method removes only the infected part of the tooth's nerve (pulpotomy), while the other removes the entire nerve (pulpectomy). The goal is to see if the simpler pulpotomy work…

This study compares two cavity removal methods in 144 adults with deep cavities and reversible pulpitis (tooth nerve inflammation that can heal). One method removes all decay, the other leaves some near the nerve. Researchers will check pain, tooth vitality, and X-rays over 12 mo…

This study compares a new material made from eggshells (calcium hydroxyapatite) to a standard one (calcium hydroxide) for protecting the nerve in deep cavities. Fifty-four adults with reversible pulpitis will receive one of the two materials after cavity cleaning. Researchers wil…

This study tests whether a less invasive dental procedure called full pulpotomy can heal infected molars as well as root canals. Researchers will treat 128 adults with deep cavities and compare healing in teeth with and without infection at the root tip. If successful, it may off…

This study looks at whether two substances in the blood of a tooth's pulp—IL-8 and presepsin—can help dentists tell the difference between a tooth infection that can heal on its own and one that needs a root canal. Researchers will collect pulp blood samples from 50 patients with…

This study will compare three methods for testing whether a tooth's nerve is alive (vital) or dead (nonvital): laser Doppler flowmetry, cold testing, and electric pulp testing. About 150 people who need root canal treatment will receive all three tests before treatment. The goal …

This study tests whether a new medicine called Fexuprazan (Fexuclue) can prevent stomach ulcers caused by NSAID painkillers like ibuprofen. About 360 adults with joint or muscle pain who need daily NSAIDs will take either Fexuprazan or an older drug (Lansoprazole) for 24 weeks. T…

This study tests whether using very cold water (around 2-3°C) to rinse the inside of a tooth during a root canal can lower pain afterward. The trial includes adults aged 20-40 with painful, infected lower molars. Participants are randomly assigned to receive either cold rinses th…

This study looks at whether using a cold saline rinse after ultrasonic cleaning during a root canal can lower pain afterward. Adults with an inflamed tooth nerve will get either ultrasonic cleaning alone or followed by a cold saline flush. Pain levels are tracked for three days a…

This study compares two strengths of sodium hypochlorite (a disinfectant used during root canals) to see which causes less pain afterward. 116 adults needing a root canal will be randomly assigned to receive either a 2.5% or 5.25% solution. Pain levels will be measured at 6, 12, …

This study compares three different root canal sealers—AH Plus, ProRoot Bio Sealer, and BC Sealer ion+—to see which one leads to the least pain after treatment. About 135 adults with irreversible pulpitis in a lower molar will be randomly assigned to one of the three sealers. Pat…

This study will compare two types of root canal sealers, NeoSealer Flo and CeraSeal, in 30 adults needing root canal treatment for painful tooth inflammation. The goal is to see which sealer causes less pain after the procedure and less leakage of material beyond the tooth tip. P…

This study tests four different ways to clean infected root canals to see which one reduces bacteria and pain the most. Forty adults with tooth infections will be randomly assigned to one of the cleaning methods. The goal is to find a better way to disinfect teeth while making th…

This study looks at whether using different root canal tools (TruNatomy vs ProTaper Gold) and different sealers (AH Plus vs TotalFill BC) can reduce pain after a root canal. About 144 adults with a tooth infection will take part. They will rate their pain at several times over a …

This study compares two ways of using an anti-inflammatory drug (ketorolac) during root canal treatment: one at room temperature and one chilled. The goal is to see if the cold version reduces pain better after the procedure. Sixty adults with tooth infections will be enrolled, a…

This study compares different numbing methods to reduce pain during dental cavity treatment. About 204 adults with tooth decay will receive either a light-based device, a numbing gel, or a placebo before local anesthesia. Researchers will measure pain during and after the procedu…

This study tests whether special scaffolds placed inside a tooth after removing the infected pulp can lower pain and improve healing. About 36 adults with a painful, infected lower molar will be treated and followed for up to a year. The goal is to find a better way to save the t…

This study compares two ways of doing a pulpotomy (a type of root canal) for adults with a painful, infected tooth. Half the treatments will use a special dental microscope, and half will not. The goal is to see if the microscope helps the tooth heal better over time. Fifty healt…

This study compares two ways of applying cold inside a tooth during a root canal to see which reduces pain better. Ninety adults with a painful, inflamed tooth nerve will be randomly assigned to receive either ice sticks, a cold spray, or no extra cold treatment. Patients will ra…

This early-phase trial will test four orthobiologic treatments—PRP, bone marrow concentrate, hyaluronic acid, and nanofat—in 300 adults with various muscle, joint, tendon, or bone conditions. The goal is to see if these natural substances can reduce pain and improve joint functio…

This study tests whether using a special rotary file (a spinning tool) causes less pain after a baby tooth root canal than the traditional manual file. Fifty children aged 4 to 6 with an infected baby molar will be randomly assigned to one of the two methods. Parents will rate th…

This study looks at whether using a special rotating tool (rotary file) instead of a hand tool (manual file) during a baby molar root canal (pulpectomy) makes children behave better. It will include 54 children aged 4-6 who need this treatment. The main goal is to see if the rota…

This study compares two ways to numb a painful lower back tooth before a root canal. One method uses a standard injection near the jaw nerve, while the other uses a different numbing medicine injected near the tooth. The goal is to see which approach provides better pain relief d…

This study tests whether applying cold (cryotherapy) to the gums right after a numbing shot can make root canal treatment less painful. About 100 adults with an infected lower premolar tooth will be randomly assigned to receive standard numbing methods with or without the cold tr…

This study compares two types of dental sealers used after root canal treatment to see which causes less pain. About 118 adults with painful tooth inflammation will receive either a tricalcium silicate sealer or a resin-based sealer. Pain levels will be measured at 24 hours, 72 h…

This study tests whether using a dental operating microscope during a pulpotomy (a partial root canal) reduces pain and improves quality of life afterward. 82 adults with deep cavities and tooth nerve pain will be randomly assigned to get the procedure with or without the microsc…

This study looks at whether a mobile app can help people with common pains (neck, shoulder, back, or knee) do their prescribed home exercises more regularly. About 30 adults will be split into two groups: one using the app and one doing traditional exercises. The goal is to see i…

This study aims to find out which of two root canal sealers causes less pain after treatment. Sixty adults with tooth nerve inflammation will have root canals and then rate their pain over two days. The goal is to improve patient comfort and recovery.

This study compares two single-dose pain relievers—piroxicam and prednisolone—given before a root canal to see which one reduces pain better afterward. Sixty adults with an inflamed tooth nerve and infection will take one of the drugs right before treatment. The goal is to find a…

This study compares two ways to manage pain after a root canal. One group gets ibuprofen alone, the other gets ibuprofen plus alprazolam, a medicine that reduces anxiety. 110 adults with tooth pain will rate their pain over 24 hours. The goal is to see if adding alprazolam leads …

This study looks at two ways of cleaning a tooth's root canal to see which one causes less pain afterward. It involves 72 adults with a specific type of tooth nerve pain in their front teeth. Participants will have their root canals cleaned using one of two methods, then rate the…

This observational study will look at 10,000 adults in intensive care units (ICUs) around the world during a single 24-hour period. Researchers want to find out how common infections and antibiotic-resistant bacteria are, how they are treated, and how patients recover. No new tre…

This research project aims to understand why older adults get more infections and why those infections can be more serious. By following 23,000 people aged 60 and older, scientists will collect health data and samples like blood and stool to study how the immune system changes wi…

This study aims to translate and adapt a widely used questionnaire for musculoskeletal problems into Urdu. Researchers will enroll 110 Urdu-speaking adults, including patients with muscle or joint issues and healthy volunteers. The goal is to create a validated tool to measure sy…

This study looks at how patients feel when reading their own medical notes. Some will read the original doctor's note, others will read a simpler version written by artificial intelligence. Researchers want to see if the AI summary changes how much patients trust their doctor or …

This early-stage study will give a single dose of the experimental antibiotic gepotidacin to 20 hospitalized children aged 2 to 12 who are already receiving standard antibiotics for a bacterial infection or as a preventive measure. Researchers will measure how the drug moves thro…

This observational study will collect pulp tissue from 1,200 adults during routine dental procedures like root canals or extractions. Researchers will analyze the tissue to understand the immune and inflammatory response at the molecular level. The goal is to see if current diagn…

This study looks at inflammation inside the tooth's inner tissue (dental pulp) in people with painful pulpitis compared to healthy individuals. Researchers will measure specific inflammation markers in saliva, gum fluid, and pulp tissue to see if they reflect the level of inflamm…

This study will follow 75 adults who need root canal treatment or retreatment at a hospital dental clinic in Rome. Researchers will check how well the teeth heal using X-rays and symptom reports over up to 5 years. The goal is to understand success rates and how factors like over…

This study will collect blood samples from 30,000 adults in the UK with various health conditions, including blood clots, infections, heart disease, diabetes, and more. The samples will be used to develop and fine-tune new diagnostic tests for the cobas® lumira device, which allo…

This study will follow 300 adults with severe infections in the ICU to see how levels of specialized pro-resolving mediators (SPMs)—natural molecules that help stop inflammation—change over time. Researchers will use blood samples already collected during routine care, so no extr…

This study tests a decision support system called SmaRTWork to help people on sick leave due to muscle or back pain return to work. About 298 adults in Norway will either use the system or receive usual care. The main goal is to see if the tool helps them return to work sustainab…

This study looks at certain proteins (aquaporins and IL-8) in the fluid and tissue of healthy teeth and teeth with a painful, inflamed nerve (irreversible pulpitis). Researchers will collect samples from 70 adults during routine root canal treatment to compare protein levels. The…

This study looks at 58 children with deep cavities in their baby molars. Dentists will perform a pulpotomy (removing the infected nerve and sealing the tooth) and measure levels of cytokines—substances that signal inflammation—in the pulp. The goal is to see if these levels can p…