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Ice vs. spray: which chills root canal pain best?

NCT ID NCT07264829

Symptom relief Sponsor: Dow University of Health Sciences Source: ClinicalTrials.gov ↗

What the study statuses mean

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Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting This study
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Aug 26, 2026 · Updated 2 times

Summary

This study compares two ways of applying cold inside a tooth during a root canal to see which reduces pain better. Ninety adults with a painful, inflamed tooth nerve will be randomly assigned to receive either ice sticks, a cold spray, or no extra cold treatment. Patients will rate their pain and anxiety before, during, and after the procedure to find out which method works best.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 90 people

The number the study aims to enrol. It can still change while the study runs.

Expected to start

Sep 2026

An estimate. Start dates often move.

Expected to finish

Dec 2026

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 40 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: 1. Individuals (Male and Female) aged 18 to 40 years. 2. Healthy individuals with no significant present and past medical findings. 3. Mandibular molars. 4. Symptomatic irreversible pulpitis (moderate to severe pain according to VAS 4-10). 5. Periapical index (PAI) Score: 1-3 on periapical radiograph. 6. DAS-R: 4-14( mild to moderate anxiety) Exclusion Criteria: 1. Immature teeth with open apices. 2. Calcified pulp chamber and canals. 3. Periodontally compromised teeth. 4. Individuals who had taken steroids, analgesics, or antibiotics within the last 48 hours.

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Conditions

The condition(s) this trial relates to.

pulpitis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Cryotherapy effect Intra-operative pain Root canal treatment Symptomatic irreversible pulpitis

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Dow University of Health Sciences

    Karachi, Sindh, 75600, Pakistan

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