Could a simple injection make root canals less painful?

NCT ID NCT07704398

First seen Jul 15, 2026 · Last updated Jul 16, 2026 · Updated 1 time

Summary

This trial tests whether a corticosteroid injection given before root canal treatment can reduce pain and inflammation afterward. One hundred adults with symptomatic pulpitis (tooth nerve inflammation) are randomly assigned to receive either standard root canal treatment alone or standard treatment plus a submucosal injection of betamethasone and gentamicin. Researchers measure pain levels and inflammatory markers in the gum fluid over four days to see if the injection helps.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance
a submucosal injection of betamethasone and gentamicin
What this could lead to
If effective, this injection could become a standard addition to root canal treatment to reduce pain and speed recovery.
What could go wrong
This is a single-center trial with 100 participants, so results may not apply broadly. The injection carries a small risk of allergic reaction or infection.

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Conditions

The condition(s) this trial relates to.

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Contacts and locations

Locations

  • Yelda Erdem Hepşenoğlu

    Istanbul, Atakent Mahallesi, Turkey (Türkiye)

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