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Could a simple injection make root canals less painful?

NCT ID NCT07704398

Symptom relief Sponsor: Istanbul Medipol University Hospital Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jul 15, 2026 · Last updated Jul 16, 2026 · Updated 1 time

Summary

This trial tests whether a corticosteroid injection given before root canal treatment can reduce pain and inflammation afterward. One hundred adults with symptomatic pulpitis (tooth nerve inflammation) are randomly assigned to receive either standard root canal treatment alone or standard treatment plus a submucosal injection of betamethasone and gentamicin. Researchers measure pain levels and inflammatory markers in the gum fluid over four days to see if the injection helps.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
a submucosal injection of betamethasone and gentamicin
What this could lead to
If effective, this injection could become a standard addition to root canal treatment to reduce pain and speed recovery.
What could go wrong
This is a single-center trial with 100 participants, so results may not apply broadly. The injection carries a small risk of allergic reaction or infection.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

100 people

The number who actually took part.

Started

Oct 2023

Finished

Apr 2026

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 65 years

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Patients diagnosed with symptomatic irreversible pulpitis * Presence of spontaneous pain or pain persisting after removal of the stimulus * Teeth indicated for endodontic treatment * Systemically healthy individuals * Patients able to read and sign the informed consent form * Patients able to complete postoperative pain assessment forms * Patients able to attend the 4-day follow-up visit Exclusion Criteria: * Individuals with systemic disease or immunosuppression * Patients with contraindications to corticosteroid or gentamicin use * Pregnant or breastfeeding individuals * Recent use of antibiotics, analgesics, or anti-inflammatory drugs * Presence of advanced periodontal disease in the affected tooth * Presence of acute periapical or periodontal abscess * Teeth with previous endodontic treatment

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Conditions

The condition(s) this trial relates to.

periapical periodontitis pulpitis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Periapical periodontitis

Contacts and locations

Locations

  • Yelda Erdem Hepşenoğlu

    Istanbul, Atakent Mahallesi, Turkey (Türkiye)

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