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Can a new file make root canal retreatments less painful?

NCT ID NCT07779148

Symptom relief Sponsor: Minia University Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Aug 21, 2026 · Last updated Aug 21, 2026

Summary

This trial tests two ways of activating cleaning solutions during a repeat root canal procedure to see if one leads to less pain and better healing. Adults with a failed root canal in a single-rooted tooth will be randomly assigned to receive either Xp Finisher R file activation or ultrasonic activation. Pain levels are measured at 24, 48, and 72 hours, and healing is checked with 3D imaging. The goal is to find a technique that makes retreatment more comfortable and successful.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Xp Finisher R file and ultrasonic activation of irrigation during endodontic retreatment
What this could lead to
If one method works better, it could point to a standard way to reduce pain and improve healing after root canal retreatment.
What could go wrong
This is a small early-stage trial, so results may not apply to everyone. Pain and healing can vary widely between individuals.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 34 people

The number the study aims to enrol. It can still change while the study runs.

Started

Aug 2026

Expected to finish

Aug 2027

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

13 to 60 years

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Patients with mature teeth. * Patients with failed previous Endo treatment related by periapical periodontitis * Single Rooted with single root canal. * Patients should be free from any systemic disease that may affect predictable outcome. * Patients who agree to the consent and will commit to follow-up period Exclusion Criteria: * Patients with immature roots. * Patients with any systemic disease that may affect normal healing. * Patients with swelling. * Pregnant females. * Patients who could/would not participate in follow-up. * Patients with old age. * Teeth with periodontal involvement. * Teeth with vertical root fractures. * Non-restorable teeth

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Conditions

The condition(s) this trial relates to.

periapical periodontitis pulpitis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Endodontic inflammation

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Dentistery Hospital, Minia University

    RECRUITING

    Minya, Egypt

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