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New tooth root sealer aims to boost healing and cut pain

NCT ID NCT07684014

Disease control Sponsor: Ain Shams University Source: ClinicalTrials.gov ↗

What the study statuses mean

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Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused This study
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jul 06, 2026 · Last updated Jul 08, 2026 · Updated 2 times

Summary

This study tests a new heat-resistant calcium silicate-based sealer used during root canals in people with infected tooth roots (apical periodontitis). The sealer is applied with different filling techniques to see if it improves bone healing and reduces pain after treatment. Participants are healthy adults aged 20-50 with a single infected molar. The trial compares healing rates and pain levels over one year.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Dia-Root Bio Sealer (calcium silicate-based sealer)
What this could lead to
If successful, this sealer could improve healing of infected tooth roots and reduce post-treatment pain, offering a more effective root canal option.
What could go wrong
This is a small, early-stage study with 63 participants, so results may not apply to everyone. The sealer might not improve healing or pain compared to standard methods.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

63 people

The number who actually took part.

Started

Jul 2025

Expected to finish

Dec 2028

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

20 to 50 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Medical condition: Medically free patients. * Age: Ranging from 20-50 years old * Gender: Male and female patients * Teeth: Patients with mandibular permanent mature molar(s) diagnosed with necrotic pulps and with apical periodontitis (asymptomatic, symptomatic apical periodontitis, or chronic periapical abscess), with at least one of the roots showing radiographic evidence of periapical lesion. * Preoperative radiographic (CBCT) lesion size should range from 2 - 4 mm. * Patients who fulfill these criteria, agree to participate, and sign the informed consent Exclusion Criteria: * Participants with generalized periodontal disease, and those who are pregnant, breastfeeding, or have any systemic disease. * Teeth diagnosed with immature apices, root resorption, or non-restorable. * Patients in which the clinical assessment necessitates multiple-visits treatment, such as those with signs and symptoms of acute or diffuse infection. * Patients who had pre-treatment antibiotic therapy or analgesics and within 7 days. * Patients who fail to complete their final restoration postoperatively. * Patients who will refuse to sign the informed consent. * Root canals requiring apical preparation larger the #40.

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Conditions

The condition(s) this trial relates to.

chronic apical periodontitis dental pulp necrosis periapical periodontitis suppurative periapical periodontitis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Chronic periapical periodontitis Periapical abscess Periapical periodontitis Pulp necrosis Pulp necrosis, apical periodontitis

How to take part

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  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    The full official record for this study. This one lists no contact details, but it is the first place any would appear.

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  3. A doctor treating you

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Contacts and locations

Locations

  • Faculty of Dentistry, Ain Shams University

    Cairo, Egypt

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