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Could a new filling material save baby teeth when adult teeth are missing?

NCT ID NCT07772986

Disease control Sponsor: Osama Seif El-Nasr Hussein Gad El-Hak Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Aug 19, 2026 · Last updated Aug 21, 2026 · Updated 2 times

Summary

This trial explores whether a bioceramic sealer, used alone, can effectively fill root canals in baby molars when the permanent successor is missing. Thirty healthy children with deep decay in a lower second baby molar will receive the treatment and be followed for up to two years. The goal is to see if the sealer keeps the tooth pain-free and healthy, offering a potential alternative to extraction.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
bioceramic sealer (Ceraseal)
What this could lead to
If successful, this could offer a simpler, effective way to fill root canals in children's baby teeth when the permanent tooth is absent, potentially avoiding extractions.
What could go wrong
This is a small, early feasibility study with only 30 children, so results may not apply broadly. The sealer's long-term performance in baby teeth is still uncertain.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 4

Runs after approval, following long-term safety and how well the treatment works in everyday use.

Participants

30 people

The number who actually took part.

Started

Mar 2023

Finished

Jun 2026

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

5 to 12 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Healthy (ASA I or II) children. * Cooperative (Frankel behavior rating 3 or 4) children * children having at least one mandibular primary 2nd molar with deep carious lesion. * No radiographic evidence of the developing permanent successor on orthopantomogram. * Signs and symptoms typical of irreversible pulpitis or pulp necrosis. * patients with minimal crowding (1-3 mm) or perfect alignment according to the Little's Irregularity Index in the lower arch. Exclusion Criteria: * Non-restorable primary molars. * Primary molars with severe infra-occlusion. * Presence of iatrogenic or pathological perforation of the pulpal floor. * Post-deroofing presence of healthy vital pulp, presenting as uniformly reddish pink vascular tissue. * Preoperative radiograph showing signs of internal or external pathological root resorption. * Root canal calcification.

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Conditions

The condition(s) this trial relates to.

dental pulp necrosis pulpitis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Bioceramic sealer Pulpectomy

Contacts and locations

Locations

  • Minia University Dental Hospital

    Minya, Egypt

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