Ancient toothbrush plant tested as a modern pulp saver

NCT ID NCT07630181

Not yet recruiting Disease control Sponsor: Postgraduate Medical Institute, Lahore Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests whether a paste made from Salvadora persica (a plant used in traditional toothbrushes) mixed with zinc oxide can work as well as the standard material (MTA) for treating severe tooth inflammation. The trial involves 78 adults aged 18-40 with infected permanent molars. Researchers will check for pain, swelling, and signs of infection over six months to see if the natural alternative is a viable, low-cost option.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Salvadora persica extract mixed with zinc oxide powder
What this could lead to: If successful, this natural and low-cost material could offer an accessible alternative to standard treatments for saving infected teeth, especially in low-resource settings.
What could go wrong: This is a small, early-stage trial with only 78 participants and a short 6-month follow-up. The natural extract may not perform as well as the standard material, and long-term outcomes are unknown.

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Conditions

The condition(s) this trial relates to.

pulpitis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

IRREVERSIBLE PULPITIS

Contacts and locations

Locations

de Montmorency college of dentistry lahore

Lahore, Punjab Province, 54000, Pakistan

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