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Could a tooth's own pulp be used to regenerate root canals?

NCT ID NCT03833401

Terminated ⭐️ CURE ⭐️ Sponsor: University of California, Los Angeles Source: ClinicalTrials.gov ↗

First seen Jul 23, 2026 · Last updated Jul 24, 2026 · Updated 1 time

Summary

This trial tests whether transplanting a patient's own minced pulp tissue into a cleaned root canal can regenerate living dental pulp. Fifty participants aged 7 to 50 with infected or inflamed teeth will receive either standard root canal treatment or the experimental tissue transplant. The study will track healing, nerve function, and tooth growth over two years.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance
transplantation of the patient's own minced pulp tissue into the cleaned root canal
What this could lead to
If it works, this could lead to a treatment that regenerates living pulp inside a tooth, potentially saving teeth that would otherwise need extraction.
What could go wrong
This is an early-stage trial with a small number of participants. The procedure may not reliably regenerate pulp tissue, and there is a risk of infection or failure of the transplanted tissue.

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Conditions

The condition(s) this trial relates to.

dental pulp necrosis pulpitis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

DENTAL PULP REGENERATION

Contacts and locations

Locations

  • UCLA School of Dentistry

    Los Angeles, California, 90095, United States

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