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Could a tooth's own pulp be used to regenerate root canals?

NCT ID NCT03833401

Cure Sponsor: University of California, Los Angeles Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled This study
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jul 23, 2026 · Last updated Jul 24, 2026 · Updated 1 time

Summary

This trial tests whether transplanting a patient's own minced pulp tissue into a cleaned root canal can regenerate living dental pulp. Fifty participants aged 7 to 50 with infected or inflamed teeth will receive either standard root canal treatment or the experimental tissue transplant. The study will track healing, nerve function, and tooth growth over two years.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
transplantation of the patient's own minced pulp tissue into the cleaned root canal
What this could lead to
If it works, this could lead to a treatment that regenerates living pulp inside a tooth, potentially saving teeth that would otherwise need extraction.
What could go wrong
This is an early-stage trial with a small number of participants. The procedure may not reliably regenerate pulp tissue, and there is a risk of infection or failure of the transplanted tissue.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Started

Feb 2019

Expected to finish

Jun 2021

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

7 to 50 years

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Healthy male or female participants at ages of 7 - 50 y.o. presenting with a tooth diagnosed with complete or partial necrosis of the pulp or irreversible pulpitis. * Participants presenting with donor pulp tissue, either from existing deciduous teeth or from permanent teeth treatment planned for extraction, e.g., second premolars for orthodontic extraction or third molars. * Participants presenting with irreversible pulpitis and partial necrosis, i.e., visible pulpal tissues during access opening and canal debridement. * Participants with immature root apices, including those with partially closed apex, that require root canal procedure. Exclusion Criteria: * Participants with any systemic conditions preventing routine dental procedures or requiring medication that interfere with healing or induce bleeding. * Participants with avulsed, replanted teeth with resultant pulp necrosis. * Participants with vertical root fracture/cracks. * Participants with teeth that are not restorable.

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Conditions

The condition(s) this trial relates to.

dental pulp necrosis pulpitis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Dental pulp regeneration

Contacts and locations

Locations

  • UCLA School of Dentistry

    Los Angeles, California, 90095, United States

More trials for these conditions

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