Could a simple paste replace drilling for Kids' tooth infections?

NCT ID NCT07542639

Not yet recruiting Disease control Sponsor: University of Sao Paulo Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study compares a new, simpler treatment called CTZ paste against the standard root canal procedure for infected baby teeth in emergency settings. The CTZ paste is placed directly into the tooth without drilling or cleaning the root canals, aiming to kill bacteria and save the tooth. Researchers will follow 110 children for one year to see if the paste controls pain and infection as well as the standard method, potentially making treatment faster and more accessible in public health clinics.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: CTZ paste (chloramphenicol, tetracycline, zinc oxide, eugenol)
What this could lead to: If it works, this could offer a faster, simpler treatment option for infected baby teeth, making dental care more accessible in public health settings.
What could go wrong: This is a very early (Phase 1) trial with only 110 children at one center. The CTZ paste may not be as effective as the standard procedure, and long-term results are unknown.

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Conditions

The condition(s) this trial relates to.

dental pulp disorder dental pulp necrosis Fistula pulpitis suppurative periapical periodontitis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

DENTAL CARE FOR CHILDREN ENDODONTICS HEALTH SERVICES ACCESSIBILITY PRIMARY TEETH PULP DISEASE, DENTAL PULP NECROSIS PULP THERAPY IN PRIMARY MOLARS PULPECTOMY QUALITY OF LIFE TREATMENT OUTCOME

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