Dental pulp disorder

This study looks at whether the position of a deep cavity (on the chewing surface or between teeth) affects how well a tooth-saving procedure called direct pulp capping works. Researchers will treat 154 people aged 15-40 with reversible pulpitis, a condition where tooth pain goes…

This study tests two methods for cleaning deep cavities in permanent teeth: removing all decayed tissue (total removal) or leaving a thin layer near the nerve (selective removal). Researchers want to see which approach better keeps the tooth alive and causes less pain after treat…

This study compares two treatments for infected baby molars in children aged 5 to 8. One group gets a standard antibiotic paste, the other gets simvastatin (a common cholesterol drug). Both are placed inside the tooth after cleaning, and the tooth is sealed. Researchers will chec…

This study compares two dental procedures to treat deep cavities in back molars that have moderate pulpitis (inflamed tooth nerve). In one method, the dentist removes only part of the decay and places a protective material over the remaining decay. In the other, all decay is remo…

This study compares eggshell powder to Biodentine for treating tooth pulp exposure in children's baby molars. Thirty kids with deep cavities but no infection will get a pulpotomy, where the damaged pulp is removed and the material is placed. Researchers will check for pain, swell…

This study compares two dental treatments—pulpotomy and pulpectomy—for deep cavities in baby teeth that cause pain. About 40 children aged 4 to 6 will receive one of the treatments. Researchers will check x-rays and symptoms to see which approach works better and is more comforta…

This study compares two treatments for extremely deep cavities that reach the tooth's nerve: a full pulpotomy (removing only the top part of the nerve) versus a standard root canal. About 93 people aged 12 and older with a deep cavity in a permanent tooth will be randomly assigne…

This study tests whether two forms of demineralized dentin matrix (a material made from tooth tissue) can help regenerate immature permanent teeth in children aged 9 to 15. The trial compares these materials to a standard sealing material called RetroMTA. Over 12 months, research…

This study compares two dental procedures—complete pulpotomy and root canal treatment—in 106 adults with type 2 diabetes who have a painful tooth condition called irreversible pulpitis. The goal is to see which treatment is more successful at relieving pain, healing the tooth, an…

This study compares two irrigation systems, GentleWave and EdgePro, for cleaning infected root canals in teeth with dead nerves. Researchers will measure how much bacteria is reduced after treatment. 30 adults with permanent teeth needing root canal treatment will participate.

This study tests whether injecting the steroid dexamethasone near the tooth ligament or under the gum helps numb the tooth better and reduces pain during root canal treatment. It includes 84 adults with severe, irreversible pulpitis in a lower molar. Participants receive one of t…

This study tests whether a specially prepared (buffered) numbing shot works better than the standard shot to reduce pain and anxiety in children aged 6 to 12 who need a tooth filling or root canal for an infected baby tooth. Researchers will measure pain using a behavior scale, h…

This study compares two methods of numbing the lower back teeth in children who need emergency dental treatment. One method is a standard injection near the jaw nerve, and the other uses a computer-controlled device to deliver numbing medicine directly into the tooth area. Resear…

This study tests three treatments for teeth with deep cavities and severe, constant pain: total pulpotomy, radicular pulpotomy, and standard root canal. About 99 adults will receive one of these procedures, and their pain and healing will be tracked for a year. The goal is to fin…

This study tests whether placing ibuprofen, nitrofurantoin, or calcium hydroxide inside a tooth after root canal treatment can lower pain. About 111 adults with dead nerves in their back teeth will rate their pain on a 0-10 scale. The goal is to find which medication works best t…

This study looks at whether doing breathing exercises before orthopedic surgery (like knee, hip, or fracture repair) can help your lungs work better after the operation. It involves 36 adults who have used tobacco and are at risk for breathing problems after surgery. Participants…

This study tests whether giving patients an extra injection of a long-acting anesthetic (bupivacaine with epinephrine) right after a root canal can lower pain, improve quality of life, and reduce the need for painkillers. About 150 adults with tooth pain will be randomly assigned…

This study tests whether placing an ice pack on the gum for 5 minutes before a numbing injection can improve pain control during root canal treatment. It involves 98 adults with severe, irreversible tooth nerve pain. The goal is to see if this simple cold therapy reduces the need…

This study compares two common root canal filling techniques—cold lateral condensation and warm vertical obturation—to see which causes less pain afterward. About 80 adults with infected but pain-free teeth will be randomly assigned to one method. Researchers will measure pain le…

This study tests three different agents (sodium hypochlorite, chlorhexidine, and cold saline) to stop bleeding during a partial pulpotomy, a dental procedure that removes part of the tooth's pulp. Researchers will track pain levels and pulp survival in 75 adults with cavities tha…

This study tests two materials, MTA and Biodentine, for treating a painful tooth condition called irreversible pulpitis. 60 adults with severe tooth pain will get a pulpotomy (removing infected pulp) and one of the materials. They will be followed for 3 months to see which materi…

This study tests whether using a special laser along with standard ultrasonic cleaning can reduce pain and kill more bacteria after a root canal. About 120 adults with infected single-root teeth will be treated and asked to rate their pain. The goal is to find a better way to man…

This study tests whether a program of exercise and ergonomics training can reduce muscle and joint pain in teachers. About 80 teachers who have had pain for at least three months will be randomly assigned to receive the training or not. Researchers will measure changes in pain, d…

This study looks at two types of dental sealers used in root canals to see which one causes less pain afterward. About 50 adults with tooth pain will get one of the two sealers and report their pain for three days. The goal is to help dentists choose the sealer that makes root ca…

This study tests a web-based app called IAMABLE that provides evidence-based rehabilitation strategies for people with chronic conditions like heart disease, arthritis, or neurological disorders. Fifty adults aged 45 to 75 will use the app for 4 months to set goals and learn abou…

This study tests a new way to do root canals that skips the manual step of scouting and widening the canal by hand. Instead, dentists use a special rotary file from the start. The goal is to see if this causes less pain after the procedure compared to the traditional method. The …

This study tests whether using a gentle laser along with a special dental cement can reduce pain after a pulpotomy, a procedure that saves a tooth with a severe nerve infection. About 46 children and young adults aged 9 to 14 with a painful lower molar will be randomly assigned t…

This study compares a laser-based procedure to the standard method for treating severe toothache (irreversible pulpitis) in adult molars. Sixty participants will receive either laser or conventional treatment, and healing will be tracked using X-rays and AI analysis. The goal is …

This study tests whether Trinase, an enzyme-based anti-inflammatory medication, can reduce pain after root canal treatment. 182 men with moderate to severe tooth pain will receive either Trinase or a placebo 30 minutes before the procedure. Pain levels and the need for extra pain…

This study compares pain levels after root canal treatment using two different sealing materials: a resin-based sealer and a bioceramic sealer. 180 adults with a single-rooted tooth needing a root canal will be randomly assigned to one of the two sealers. Pain will be measured 24…

This study tests two different dental file systems—EdgeOne Fire (reciprocating motion) and Jizai (rotary motion)—to see which causes less pain during and after root canal treatment in upper premolars with infected pulp. Fifty-six adults with moderate spontaneous pain will be rand…

This study tests whether extra support for case managers helps veterans leaving the military better manage pain and reduce risky substance use. About 1800 veterans will take part. The program focuses on non-drug pain treatments and counseling.

This study looks at whether making the tip of a root canal wider or using different taper sizes helps the tooth heal better and causes less pain afterward. Researchers will treat 270 adults with infected, dead nerves in their lower back teeth. Participants will get one of three r…

This study aims to learn more about rare skeletal disorders by collecting medical records, blood samples, and genetic data from 100 participants. People with known or suspected bone conditions, as well as their healthy family members, can join either remotely or in person. The go…

This study translates and tests several health questionnaires—covering pain, arm and leg function, mood, and daily activities—for use with Albanian-speaking people. Researchers will check if the translated versions are reliable and accurate by giving them to about 300 participant…

This study tests a new tool called the PRISM Dashboard, which gives physiotherapists feedback on how their decisions compare to their peers. The goal is to see if this feedback helps reduce differences in care for people with muscle and joint pain. About 60 physiotherapists and t…

This study examines why some people with a painful tooth infection (irreversible pulpitis) don't get fully numb from a standard dental injection. Researchers will measure levels of certain genes and inflammatory markers in the tooth pulp to see if they predict anesthesia success.…

This study is testing a new type of dental MRI (ddMRI) to see if it can work as well as standard dental X-rays for diagnosing problems like crowded teeth, jaw pain, and infections. About 300 adults will get a ddMRI scan and then compare the results to their regular dental images.…

This study looks at how a patient's symptoms before treatment and how deep the cavity is affect the success of partial decay removal in adult teeth. One hundred adults with deep cavities will be treated and followed for 12-24 months. The goal is to see if these factors influence …

This study looks at whether substances in the blood from a decayed tooth can predict if a tooth-saving procedure called vital pulp treatment will succeed. Researchers will collect a small blood sample from the tooth during treatment and check for specific metabolic markers. They …

This study follows 252 adults with muscle, bone, or joint problems (like arthritis, back pain, or after surgery) to see how well they do their prescribed home exercises. Researchers will track who sticks with the program and why, looking at factors like pain, mood, and support. T…

This study tests whether using a virtual reality (VR) headset during shoulder exercises helps patients feel more engaged and motivated. Fifty adults with shoulder problems will do rehab exercises in a VR environment and then answer questionnaires about how easy and immersive the …

This study surveys 100 French dentists who treat children to understand why they often choose extraction for non-vital baby teeth, even though effective alternatives like pulpectomy exist. The goal is to collect and analyze their treatment choices, reservations, and decision-maki…

This study aims to create a secure national database for muscle and joint (musculoskeletal) conditions by collecting routine data from community clinics and GP practices. About 22,000 adults will have their information anonymously gathered to help develop a dashboard that tracks …

This study watches 2000 people having hip or knee replacement surgery to see how long spinal anaesthesia lasts. The goal is to learn how the amount of anaesthetic affects timing, helping doctors decide if patients can safely go home the same day. No new treatments are tested—just…

This study tests whether artificial intelligence can predict if a less invasive procedure called full pulpotomy (removing only the infected pulp) will succeed in treating painful molars, compared to standard root canal treatment. Researchers will enroll 58 adults with irreversibl…

This study looks at how changing the heel cushion on an ankle-foot brace (AFO) affects walking in people who use one daily. Forty adults with leg injuries or nerve problems will try four different heel wedges—tall or short, soft or firm—while walking at controlled speeds. Researc…

This study looks at whether the phase of a woman's menstrual cycle changes how well dental numbing works for treating a painful tooth condition called pulpitis. Researchers will give 150 women a standard numbing shot and measure pain during treatment. The goal is to see if certai…

This study looks at how 3D computer simulation and printing can help surgeons better plan and perform bone correction surgeries. Researchers will compare the planned corrections to the actual results in 100 children and young adults with rare bone deformities. The goal is to make…

This study follows 4,000 children who receive orthopedic implants (like rods or screws) during standard care for bone fractures, deformities, or hip problems. Researchers will track how long the implants last, any complications, and how well they work over time. The goal is to ga…

This study is building a registry of people with rare bone diseases (skeletal dysplasias) in Italy. Researchers will collect medical history, genetic data, and treatment details over time to better understand how these conditions progress. No experimental treatments are given; th…

This study follows 144 adults with muscle or bone problems who are already scheduled to receive treatment with Chattanooga Intelect devices (like TENS or ultrasound). Researchers will measure pain, muscle strength, and movement range to confirm the devices are safe and work as ex…

This study tests three different devices used during root canal treatment to see which one removes the most bacteria from infected teeth. Ninety adults with dead nerves in their premolars will be randomly assigned to one of the three methods. Researchers will measure bacterial le…