Could a cholesterol drug save infected baby teeth?
NCT ID NCT07264842
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study compares two treatments for infected baby molars in children aged 5 to 8. One group gets a standard antibiotic paste, the other gets simvastatin (a common cholesterol drug). Both are placed inside the tooth after cleaning, and the tooth is sealed. Researchers will check for pain, swelling, and healing on X-rays after 1, 2, and 3 months. The goal is to see if simvastatin can be a good alternative to antibiotics.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- Simvastatin paste or Triple Antibiotic Paste (Ciprofloxacin + Metronidazole + Cefixime)
- What this could lead to
- If simvastatin works, it could offer a simpler, antibiotic-free way to treat infected baby teeth and preserve them until they fall out naturally.
- What could go wrong
- This is a small, early-phase study with only 60 children and short follow-up (3 months). Simvastatin may not work as well as the standard antibiotic paste, and results may not apply to all children.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
Dow International Dental College, Chanesar goth.
RECRUITINGKarachi, Sindh, 75950, Pakistan
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