Dental pulp disorder

This study tests whether leaving a tooth's root canal unfilled and using a blood clot to trigger natural healing works as well as the standard root canal filling. The trial involves 48 men with infected but still living upper premolars. One group gets the standard gutta-percha fi…

This study tested whether adding photodynamic therapy (a light-activated treatment) to standard sodium hypochlorite irrigation better kills bacteria in root canals. 64 adults needing root canal treatment were randomly assigned to receive either sodium hypochlorite alone or with p…

This study tested three different materials used to treat severe, irreversible tooth inflammation. 72 adults with painful molars received a procedure where the damaged pulp was removed and covered with one of the materials. The goal was to see if newer materials (TheraCal LC and …

This study compared three approaches for treating dead, infected adult teeth: a regenerative procedure that induces bleeding inside the tooth, standard cleaning and sealing, and a combination. Fifty-four adults with an infected upper premolar were treated and followed for healing…

This study tested a new, less invasive way to treat infected baby molars in children aged 4 to 10. Instead of fully cleaning out the tooth canals (standard pulpectomy), the new method uses an antibiotic paste to kill infection without drilling. The study involved 110 children and…

This study tested two materials, ProRoot MTA and Biofactor MTA, for direct pulp capping—a procedure to save a tooth's nerve after exposure. Eighty permanent teeth were treated, and patients reported pain levels for 48 hours. Success was checked at 6 and 12 months by looking for s…

This study tested two types of ceramic dental restorations for teeth that have had root canal treatment: overlays and endocrowns. Twenty-five patients received one of the two restorations, and researchers checked how well they fit, any color changes at the edges, and how satisfie…

This study compared two treatments for severely decayed baby molars in children aged 4 to 9. One group received a pulpotomy, where only the infected part of the tooth's nerve is removed and replaced with a special cement (Biodentine). The other group had a full pulpectomy, removi…

This study tested a new way to treat children aged 6 to 18 who have a dead nerve in an immature tooth. The new method uses a material called MTA to help the tooth form a hard barrier, compared to the standard treatment with calcium hydroxide. The goal was to see which method work…

This study tested two simpler procedures called Lesion Sterilization and Tissue Repair (LSTR) against the standard root canal treatment (pulpectomy) for infected baby molars in 66 children. One LSTR method cleaned the root canals, while the other only removed the top pulp and pla…

This study tested whether a stronger solution of sodium hypochlorite (5% vs 3%) works better as a wash and bleeding stopper during a partial pulpotomy—a procedure to save a tooth with deep decay and nerve inflammation. The trial involved 128 adults with painful, infected molars. …

This study looked at using a special filling material called OrthoMTA for root canals in second baby molars that have no permanent tooth growing underneath. Thirteen children received the treatment and were checked for up to 12 months to see if the tooth stayed healthy and infect…

This study looked at whether a root canal for an infected tooth with an abscess can be done in one visit instead of two. Fifty-nine adults received either a single-visit treatment or a two-visit treatment with a calcium hydroxide medication placed in between. After 12 months, bot…

This study tested a less invasive treatment called vital pulp therapy against standard root canals for teeth with severe pulp inflammation. In the new approach, dentists removed only the inflamed pulp and placed a natural blood-derived material (PRF) to help the tooth heal. Forty…

This small pilot study tested a new way to treat dead (necrotic) teeth in 6 adults. Doctors took pulp tissue from a healthy donor tooth, mixed it with a growth factor concentrate (CGF), and transplanted it into the dead tooth. After 12 months, they checked if the tooth regained f…

This study tested three different materials (blood clot, platelet-rich fibrin, and concentrated growth factor) combined with two types of rinses to help regrow root tissue in 30 immature permanent teeth with dead nerves. Participants aged 9 to 25 were followed for 12 months using…

This study tested whether transplanting pulp tissue from a healthy tooth into a dead one could restore vitality. Twenty-one adults with dead single-rooted teeth received either a pulp transplant, a pulp transplant with growth factors, or standard root canal treatment. The goal wa…

This study looked at 120 healthy children aged 4-7 with deep cavities in their baby molars. Dentists removed the decay and used one of three special materials to cover the nerve, then sealed the tooth with either a filling or a metal crown. The goal was to see which combination w…

This study tested two materials, Biodentine and Calcium Hydroxide, placed under fillings to protect the tooth nerve in 76 adults with reversible pulpitis. Over 12 weeks, researchers checked pain, X-ray changes, and nerve responses to see which material better kept the tooth alive…

This study looks at whether substances in the blood from a tooth's pulp can help dentists tell the difference between reversible pulpitis (a mild inflammation that can heal) and irreversible pulpitis (severe damage needing a root canal). Researchers will collect a small sample of…

This study tested how well cold, heat, and electric pulp tests detect tooth nerve health in 175 adults needing root canals. Researchers compared test results to direct observation of nerve bleeding during treatment. The goal was to find which test is most accurate for diagnosing …

This study tested a Turkish version of the Johns Hopkins In-Room Independence Scale, which measures a patient's ability to move, use the toilet, and think clearly while in their hospital room. Researchers worked with 100 adults who had conditions like stroke, Parkinson's, or ampu…

This study tested a new pain scoring tool to help dentists tell apart reversible and irreversible pulpitis, a common diagnostic challenge. Researchers enrolled 143 patients with tooth pain and compared the tool's results with two standard classification systems. The goal was to s…

This study looked at four different ways to activate the cleaning solution used during root canals: laser, sonic, ultrasonic, and simple needle irrigation. The goal was to see which method causes the least pain after the procedure and how much debris gets pushed out of the tooth.…

This study compares two final rinses inside the tooth after root canal treatment for people with severe tooth pain from irreversible pulpitis. One rinse is a cold saline solution (cryotherapy), the other is a steroid solution (dexamethasone). The goal is to see which better reduc…

This study tested whether using special lasers during root canal treatment can lower pain afterward compared to standard methods. Forty-five adults with infected front teeth were split into three groups: one got standard cleaning, another got a combination of two lasers, and the …

This study looked at pain after root canal treatment using two types of sealers: bioceramic and resin. 72 adults with no pain before treatment had a single-root tooth filled. They rated their pain at 6, 24, 48, and 72 hours, and 7 days after. The goal was to see if the sealer typ…

This study looked at how well paracetamol alone or combined with different NSAIDs (ibuprofen, mefenamic acid, or diclofenac) controls pain after root canal treatment. 185 adults with severe tooth pain took part. The goal was to see if combining drugs works better than paracetamol…

This study tested whether taking tramadol or naproxen sodium one hour before a dental procedure helps local anesthesia work better and reduces pain afterward. 139 adults with severe tooth inflammation (irreversible pulpitis) in a lower molar were randomly given one of the two dru…

This study tested whether a technique called apical patency—gently passing a small file just beyond the tooth root during root canal treatment—reduces pain afterward. 150 adults with inflamed but painless teeth (asymptomatic irreversible pulpitis) were randomly assigned to receiv…

This trial investigates whether using an electronic apex locator to determine the exact stopping point during root canal treatment can reduce pain afterward. Participants with a single-rooted tooth needing a root canal are randomly assigned to one of three groups: two groups use …

This study tested whether using an ultrasonic device to clean root canals causes less pain afterward than a standard needle. 108 adults with tooth pain had root canals and were randomly assigned to one method. Pain was measured using a scale. The goal is to find which cleaning me…

This study tested whether pain-relieving skin patches work as well as oral tablets for pain after root canal treatment. 80 adults with tooth pain received either a ketoprofen or fentanyl patch, or an oral medication. They rated their pain over 48 hours. The goal was to see if pat…

This study tested whether taking a combination of trypsin, bromelain, and rutoside before a root canal helps the numbing shot work better and lowers pain after the procedure. 124 adults with painful tooth inflammation (pulpitis) took the medication or a placebo. The goal was to i…

This study looked at whether using a special laser (diode laser) after a common dental procedure called direct pulp capping can help reduce pain and tooth sensitivity. Fifty-six people with tooth decay that reached the nerve were treated. Half got standard care, and half got stan…

This study compared an oral steroid (prednisolone) to a partial root canal for relieving severe tooth pain from pulpitis. Only 5 adults with a painful lower molar took part. The goal was to see if the pill could reduce pain enough to delay the full root canal by 72 hours, potenti…

This study tested three biocompatible materials—TheraCal PT, Biodentin, and MTA—for reducing pain after a pulpotomy (removing the inner pulp) in 51 adults with severe toothache. Participants rated their pain before and up to 7 days after treatment. The goal is to find which mater…

This study compared two common painkillers—diclofenac sodium and ibuprofen—for managing pain after a root canal. Sixty adults with irreversible pulpitis received one of the two drugs right after treatment, and their pain was tracked for 48 hours. The goal was to see which drug pr…

This study compared two ways to fill a root canal after treating a painful tooth infection (irreversible pulpitis). 56 people aged 18-60 took part. One group got a continuous wave condensation filling, the other a single-cone filling. Researchers measured how long each method too…

This study tested whether injecting dexamethasone, diclofenac sodium, or chymotrypsin into the gum before numbing medicine can make dental treatment less painful. 105 men with severe toothache took part. The goal was to see if these drugs help the numbing work better so patients …

This study tested whether applying cryotherapy (ice or cold saline) during dental procedures for deep cavities reduces pain and improves quality of life. 144 adults received either a pulpotomy or root canal treatment, with or without cryotherapy. The goal was to see if the cold t…

This study looked at 146 adults with painful tooth inflammation who needed root canal treatment. It compared two different tools (WaveOne and ProTaper) to see which one leads to less pain after the procedure. Patients rated their pain at several times over a week. The goal is to …

This study tested three different rinses used during root canal treatment to see which one causes the least pain afterward. Ninety adults with tooth pain took part, and each received one of the rinses: sodium hypochlorite, hydrogen peroxide, or normal saline. Pain levels were mea…

This study tested a procedure called full pulpotomy (removing only the infected pulp inside the tooth crown) in 58 adults with severe toothache. It compared success in teeth with and without an infection at the root tip (apical periodontitis), using an AI tool to help detect the …

This study looked at 120 people who needed root canal treatment on their molars. Researchers tested different filling materials (bioceramic vs. resin-based) and techniques (cold vs. warm filling) to see which caused the least pain afterward. The goal is to help dentists choose op…

This study looked at how common muscle and posture problems are in physiotherapy students and whether a special physiotherapy program could help. 44 students with back pain and muscle tightness received treatments like trigger point release, stretching, and joint mobilization. Th…

This study tested whether watching a short animated movie through a VR headset can help control the gag reflex and reduce anxiety in adults during dental X-rays. Thirty patients each had two X-rays: one with standard care and one with VR distraction. Researchers measured gagging …

This study tested two medications placed inside the tooth after an emergency root canal to see which one reduces pain better. 43 adults with severe tooth pain (pulpitis) received either calcium hydroxide or Tobradex (an antibiotic-steroid combo). Pain levels were measured before …

This study tested three different root canal filling materials in 54 people with inflamed tooth pulp to see which caused the least pain after a single-session root canal. Patients rated their pain over 7 days. The goal is to find a material that makes root canals more comfortable…

This study looked at 60 adults with painful tooth inflammation (pulpitis) who needed a root canal. Researchers compared two types of sodium hypochlorite (a common disinfectant) — one made for dental use and one household bleach — to see which caused less pain after the procedure.…

This study tested two different materials—surgical glue and ferric sulfate—to control bleeding during root-end surgery in 34 patients with infected tooth roots. Researchers measured how well each agent stopped bleeding, how much pain patients felt afterward, and their quality of …

This study looked at whether taking a single dose of the painkiller diclofenac before a root canal can reduce pain afterward. 160 adults with tooth pain from irreversible pulpitis were split into two groups: one took 100 mg of diclofenac 30 minutes before the procedure, and the o…

This study looked at whether using electronic devices or X-rays to measure root canal length changes how much pain patients feel after root canal treatment. 125 adults with no prior pain or swelling took part, and each had their root canal measured with one of five methods. Patie…

This study tested whether probiotics, a double antibiotic paste, or calcium hydroxide paste can reduce pain after root canal treatment in adults with severe tooth inflammation (irreversible pulpitis). 75 participants received one of the three pastes placed inside the tooth and re…

This study tested whether photodynamic therapy (PDT) — a light-activated disinfection method — can reduce pain after root canal treatment. 95 adults with infected back teeth received either standard cleaning or PDT-enhanced cleaning. Researchers measured pain levels and painkille…

This study looked at whether letting patients control their own sedation during arm surgery under regional anesthesia leads to higher satisfaction compared to having an anesthesiologist control it. 70 adults having upper limb orthopedic surgery were randomly assigned to either pa…

This study looked at 72 adults with a painful tooth condition called irreversible pulpitis. During a dental procedure to remove the infected pulp, researchers tested whether rinsing the tooth with a dexamethasone solution or cold saline could reduce pain afterward. The goal was t…

This study looked at whether applying cold (cryotherapy) after a root canal can lower pain in people with a tooth nerve infection (irreversible pulpitis). 45 adults with a lower premolar tooth were split into three groups: one got a cold saline injection near the tooth, one got c…

This study tested whether using a sonic device (EndoActivator) to clean the tooth during a root canal reduces pain afterward. Fifty-eight adults with tooth infections were randomly assigned to get either the sonic cleaning or standard syringe irrigation. Pain was measured before …

This completed early-phase trial tested three oral painkillers—Novafen, Tramadol, and Naproxen—against a placebo (multivitamins) for pain after root canal treatment. 100 adults with tooth pain took one of the four options, and their pain was measured on a 0–10 scale. The goal was…

This completed early-phase trial tested whether giving ibuprofen before dental treatment reduces pain and stress in children with reversible pulpitis (a type of tooth inflammation). 46 children received ibuprofen 40 minutes before the procedure. The study measured pain during and…

This study looked at 130 children aged 10-15 who needed root canal treatment. Half had the tooth length measured with an electronic device (apex locator) and half with digital X-rays. The goal was to see which method caused less pain after the procedure. Pain was recorded at seve…

This study compared pain after root canal treatment using two different filling methods: the single cone cold lateral condensation technique and the continuous wave compaction technique. Sixty adults with irreversible pulpitis (tooth nerve inflammation) were randomly assigned to …

This study tested whether using a sonic device (EDDY) during root canal treatment in children's baby molars reduces pain afterward. Thirty children aged 5-8 with tooth infections received either sonic-activated cleaning or standard cleaning. Pain was measured using a face scale a…

This study tested whether taking ibuprofen and serratiopeptidase before a dental numbing shot helps it work better for people with severe tooth pain from pulpitis. 96 adults were split into four groups: placebo, ibuprofen alone, serratiopeptidase alone, or both. Pain was measured…

This study looks at whether computer models can predict if local anesthetic (numbing) will work for people with a painful tooth condition called symptomatic irreversible pulpitis. Researchers analyzed records from 4,390 adult patients to compare three different machine learning a…

This study translated the Generic Functional Index, a questionnaire that measures how well people can do daily activities, into Turkish. Researchers tested it with 200 adults who have muscle or joint problems to see if it is accurate and reliable. The goal is to give Turkish-spea…

This pilot study looked at bacteria in root canal infections, comparing painful and painless cases. Researchers used DNA testing to identify bacteria before and after cleaning with two different strengths of sodium hypochlorite. The goal was to see how well the cleaning removes b…

This study tested whether taking common painkillers like paracetamol or ibuprofen before a dental pulp sensitivity test changes the results. 184 healthy adults received either a painkiller or a placebo, and their tooth nerve responses were measured. The goal is to help dentists a…

This study looked at whether alcohol consumption affects the success of local anesthesia for people with a painful tooth condition called irreversible pulpitis. Researchers gave 70 patients (35 who drink alcohol and 35 who don't) a standard numbing injection and measured pain dur…

This small study tested two methods for cleaning infected root canals: ultrasonic activation and a 980-nm diode laser. Sixteen adults with dead (necrotic) teeth had their root canals cleaned with one of these methods. Researchers checked for leftover bacterial DNA to see which me…

This study looked at 36 adults with painful tooth nerve inflammation (irreversible pulpitis) to see if biological markers in gum fluid match symptoms. Researchers collected gum fluid samples before and after root canal treatment and measured pain levels. The goal was to find a li…

This study looked at how dental students hold their bodies while doing root canal work. Ten students were recorded on video for 5 minutes, and their posture and muscle fatigue were analyzed. The goal was to understand how their working positions might lead to pain or injury. This…

This study looked at a new way to transplant mature teeth that might help them regain blood supply. Researchers reviewed the outcomes of 16 people who had this procedure. The goal was to see if the teeth survived and if blood flow returned.

This study looked at whether a specific gene variation (SCN9A rs6746030) affects the success of numbing injections for root canal treatment. Researchers compared 200 patients with irreversible pulpitis who either had successful or failed anesthesia. By analyzing DNA from cheek sw…

This study tested whether specially trained physiotherapists can safely diagnose and treat non-urgent muscle and joint pain in the emergency room, compared to standard care from doctors. 102 patients with back, neck, or shoulder pain were randomly assigned to either a physiothera…

This study looked at whether measuring brain waves before a root canal can help predict how much pain a person will feel afterward. One hundred adults with tooth pain took part. Researchers recorded their brain activity at rest and then asked them to rate their pain after treatme…

This completed study measured two immune proteins, IL-8 and IL-10, in fluid from the gums and around the tooth root during root canal treatment. Researchers wanted to see how these levels change as treatment progresses in people with infected, dead tooth pulp. Twenty-two adults a…

This study examined whether type 2 diabetes influences how well a dental procedure called pulpotomy works in adults. Researchers compared 70 diabetic and non-diabetic patients who had a molar treated for irreversible pulpitis. They checked the tooth's health, symptoms, and X-ray …

This completed study looked at 72 adults to see how certain chemicals (Substance P and CGRP) in saliva and tooth pulp relate to dental pain, inflammation, and stress. Participants provided saliva samples and had pulp tissue collected during routine root canal treatment. The goal …

This study looked at children aged 8 to 13 with a common enamel defect called Molar-Incisor Hypomineralization (MIH). Researchers measured inflammatory markers in the pulp (nerve) of affected teeth and compared them to healthy teeth. The goal was to better understand how MIH affe…

This study looked at 51 people to compare levels of three substances (IL-8, FGF-1, and VEGF) in teeth that are healthy, mildly inflamed, or severely inflamed. Samples were taken from the tooth pulp, gum fluid, and dentin fluid during routine root canal treatment. The goal was to …

This completed study compared how well people with complex regional pain syndrome (CRPS), people with other muscle or bone pain, and healthy individuals can imagine movements. Researchers used a questionnaire called the MIQ-RS to measure motor imagery skills. The goal was to see …

This study looked at 40 people with tooth inflammation (reversible or irreversible pulpitis) to see if certain immune markers in the blood (IL-8 and IL-10) could predict how well a tooth-saving treatment (vital pulp therapy) works. Participants received the therapy, and researche…

This study surveyed 116 adults with chronic pain at a rehabilitation clinic to understand how their pain beliefs, spiritual well-being, and attitudes toward complementary and alternative medicine are related. Participants filled out several questionnaires about their pain, mood, …