Could a blood clot replace root canal fillings? new study tests regenerative approach
NCT ID NCT07679152
First seen Jul 01, 2026 · Last updated Jul 02, 2026 · Updated 1 time
Summary
This study tests whether leaving a tooth's root canal unfilled and using a blood clot to trigger natural healing works as well as the standard root canal filling. The trial involves 48 men with infected but still living upper premolars. One group gets the standard gutta-percha filling, another gets a seal but no filling, and a third gets a blood clot induced inside the canal before sealing. The goal is to see which method best resolves pain and infection signs.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- Regenerative endodontic procedure (blood clot scaffold)
- What this could lead to
- If successful, this approach could offer a simpler, more natural way to heal infected teeth without the need for permanent root canal fillings.
- What could go wrong
- This is a small, early-stage study with only 48 participants, so results may not apply to everyone. The regenerative method may not work as well as standard treatment, and there is a risk of infection or incomplete healing.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
Faculty of Dentistry, Ain Shams University
Cairo, Egypt
More trials for these conditions
Other studies related to the condition(s) this trial covers.
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- Can a blood clot or platelet fibrin help save a tooth that failed root canal?