Could a blood clot replace root canal fillings? new study tests regenerative approach
NCT ID NCT07679152
First seen Jul 01, 2026 · Last updated Jul 01, 2026
Summary
This study tests whether leaving a tooth's root canal unfilled and using a blood clot to trigger natural healing works as well as the standard root canal filling. The trial involves 48 men with infected but still living upper premolars. One group gets the standard gutta-percha filling, another gets a seal but no filling, and a third gets a blood clot induced inside the canal before sealing. The goal is to see which method best resolves pain and infection signs.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
Regenerative endodontic procedure (blood clot scaffold)
What this could lead to
If successful, this approach could offer a simpler, more natural way to heal infected teeth without the need for permanent root canal fillings.
What could go wrong
This is a small, early-stage study with only 48 participants, so results may not apply to everyone. The regenerative method may not work as well as standard treatment, and there is a risk of infection or incomplete healing.
Disclaimer
Read more
Show less
This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
Get updates
Get notified about this study
Sign up to get updates when this study changes or when new studies for IRREVERSIBLE PULPITIS are added.
By submitting, you agree to our Terms of use
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Show contact details
Enter your email to view the contact information for this study.
By submitting, you agree to our Terms of use
Locations
-
Faculty of Dentistry, Ain Shams University
Cairo, Egypt