Can a blood clot or platelet fibrin help save a tooth that failed root canal?

NCT ID NCT07721051

Not yet recruiting Disease control Sponsor: Kırıkkale University Source: ClinicalTrials.gov ↗

First seen Jul 22, 2026 · Last updated Jul 23, 2026 · Updated 1 time

Summary

This trial tests whether different scaffolds—a blood clot or various platelet-rich fibrin preparations—can improve healing in teeth that need a second root canal treatment. Sixty participants will receive one of four scaffolds during the procedure and be followed for a year. The goal is to see which scaffold best resolves infection and promotes tissue repair.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: scaffolds: induced blood clot, injectable platelet-rich fibrin (i-PRF), advanced platelet-rich fibrin (A-PRF), or advanced platelet-rich fibrin plus (A-PRF+)
What this could lead to: If one scaffold proves superior, it could improve success rates for saving previously treated teeth, reducing the need for extraction or implants.
What could go wrong: This is a small, early-stage trial with 60 participants, so results may not apply broadly. Risks include infection, pain, or the scaffold not promoting healing.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Get updates

Get notified about this study

Sign up to get updates when this study changes or when new studies for A-PRF are added.

Our safety recommendation!

By submitting, you agree to our Terms of use

Conditions

The condition(s) this trial relates to.

familial pityriasis rubra pilaris

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

A-PRF A-PRF PLUS ENDODONTICS I-PRF PRF REGENERATIVE ENDODONTIC PROCEDURES RETREATMENT

Contacts and locations

Show contact details

Study contacts

Contact

Phone: •••-•••-•••• Email: •••••@•••••
Contact

Phone: •••-•••-•••• Email: •••••@•••••

More trials for these conditions

Other studies related to the condition(s) this trial covers.