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Can a blood clot or platelet fibrin help save a tooth that failed root canal?

NCT ID NCT07721051

Disease control Sponsor: Kırıkkale University Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting This study
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jul 22, 2026 · Last updated Jul 23, 2026 · Updated 1 time

Summary

This trial tests whether different scaffolds—a blood clot or various platelet-rich fibrin preparations—can improve healing in teeth that need a second root canal treatment. Sixty participants will receive one of four scaffolds during the procedure and be followed for a year. The goal is to see which scaffold best resolves infection and promotes tissue repair.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
scaffolds: induced blood clot, injectable platelet-rich fibrin (i-PRF), advanced platelet-rich fibrin (A-PRF), or advanced platelet-rich fibrin plus (A-PRF+)
What this could lead to
If one scaffold proves superior, it could improve success rates for saving previously treated teeth, reducing the need for extraction or implants.
What could go wrong
This is a small, early-stage trial with 60 participants, so results may not apply broadly. Risks include infection, pain, or the scaffold not promoting healing.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

About 60 people

The number the study aims to enrol. It can still change while the study runs.

Expected to start

Oct 2026

An estimate. Start dates often move.

Expected to finish

Mar 2028

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

This study will include patients aged 16-40 with single-canal, closed-apical permanent teeth who presented to the Department of Endodontics at the Faculty of Dentistry, Kırıkkale University, for endodontic retreatment.

Ages

16 to 40 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Patients aged 16-40 who are systemically healthy * Patients who have a permanent tooth with a single root canal and fully developed root that requires retreatment * Patients who may or may not have periapical radiolucency Exclusion Criteria: * Patients who require antibiotic prophylaxis * Patients with systemic conditions such as diabetes or hematological disorders * Patients who have taken antibiotics, anti-inflammatory medications, and/or antidepressants within the past three weeks * Patients who are pregnant or suspect they may be pregnant during treatment * Patients with heavy plaque and tartar buildup on their teeth * Patients with redness and bleeding of the gums * Patients with severe gingivitis, generalized periodontitis, or a periodontal pocket depth of more than 3 mm * Patients with internal or external root resorption * Patients for whom complete isolation with a rubber dam cannot be achieved * Patients with an open, immature root apex * Patients with horizontal or vertical fractures * Patients with teeth having multiple roots or root canals

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Conditions

The condition(s) this trial relates to.

familial pityriasis rubra pilaris

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

A-PRF A-PRF plus Endodontics I-PRF PRF Regenerative endodontic procedures Retreatment

How to take part

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  1. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  2. A doctor treating you

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