Your DNA may determine if the Dentist's needle works

NCT ID NCT07697300

Completed Knowledge-focused Sponsor: Marmara University Source: ClinicalTrials.gov ↗

First seen Jul 13, 2026 · Last updated Jul 15, 2026 · Updated 2 times

Summary

This study looks at whether certain genetic variations (in COMT, MAOA, and SLC6A4) influence how well a standard dental numbing injection works for people with a painful tooth condition called irreversible pulpitis. Participants received a numbing shot and had their pain levels measured during root canal treatment. The goal is to see if genetics can predict who might need a different approach to achieve effective pain relief.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: 4% articaine with epinephrine
What this could lead to: If certain genes are linked to anesthesia failure, dentists could one day tailor numbing methods to a patient's genetic profile, improving pain control.
What could go wrong: This is a small, early-stage observational study. The results may not apply to all people or other types of anesthesia, and genetic testing in dentistry is not yet routine.

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Conditions

The condition(s) this trial relates to.

pulpitis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

SYMPTOMATIC IRREVERSIBLE PULPITIS (SIP)

Contacts and locations

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Locations

Faculty of Dentistry, Marmara University

Istanbul, Istanbul, 34854, Turkey (Türkiye)

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